Category: 932-35-4

Synthetic Route of 932-35-4, Adding some certain compound to certain chemical reactions, such as: 932-35-4, name is 3-Hydroxypicolinonitrile,molecular formula is C6H4N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 932-35-4.

In a round-bottom flask, mix 1.8 g (0.015 mol) of 3-hydroxypridine-2- carbonitrile, 30 ml of DMF, 9.77 g (0.30 mol) of Cs2CO3 and 2.54 g (0.018 mol) of 1-fluoro-4-nitrobenzene. Heat the reaction mass to 140 and stir at this temperature for 4 h; use the TLC method to ensure the completeness of the reaction. Distill off the solvent under redused pressure and add 40 mL of water. Filter the precipitate, wash with 15 ml of water and 15 ml of hexane. Yield: 2.86 g (79%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 932-35-4, 3-Hydroxypicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JOINT STOCK COMPANY “BIOCAD”; GAVRILOV, Aleksey Sergeevich; ALESHUNIN, Pavel Aleksandrovich; GORBUNOVA, Svetlana Leonidovna; REKHARSKY, Mikhail Vladimirovich; KOZHEMYAKINA, Natalia Vladimirovna; KUKUSHKINA, Anna Aleksandrovna; KUSHAKOVA, Anna Sergeevna; MIKHAYLOV, Leonid Evgen`evich; MOLDAVSKY, Alexander; POPKOVA, Aleksandra Vladimirovna; SILONOV, Sergey Aleksandrovich; SMIRNOVA, Svetlana Sergeevna; IAKOVLEV, Pavel Andreevich; (197 pag.)WO2018/92047; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 932-35-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 932-35-4, name is 3-Hydroxypicolinonitrile, molecular formula is C6H4N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation XV 2-Cyano-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranoside A solution of 1.7 g (14.17 mM) of 2-cyano-3-pyridinol in 80 ml of acetonitrile is prepared and 4.3 g (18.3 mM) of silver oxide and 3 g of 13* molecular sieve are added with the exclusion of light. The mixture is stirred at 50 C. for 10 min, 6.5 g (18.3 mM) of 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranosyl bromide are then added and the reaction mixture is maintained at 50 C. for 18 hours with stirring. The mixture is subsequently cooled to ambient temperature and filtered through a filtration aid. The filtrate is diluted with ethyl acetate, washed with water, an N sodium hydroxide solution and then water to neutral pH and finally dried over magnesium sulfate and concentrated under reduced pressure. The residual oil is crystallized by addition of ethyl ether. 0.89 g of the expected product is obtained in the form of beige crystals (yield=16%). 1H NMR (300 MHz; CDCl3) delta: 8.43 (m, 1H), 7.53 (m, 2H), 5.49 (t, 1H), 5.30 (d, 1H), 5.19 (m, 2H), 3.18 (m, 1H), 2.76 (m, 1H), 2.10 (m, 9H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 932-35-4, 3-Hydroxypicolinonitrile.

Reference:
Patent; Laboratoires Fournier S.A.; US2009/182013; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 932-35-4, 3-Hydroxypicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 932-35-4, blongs to pyridine-derivatives compound. Recommanded Product: 932-35-4

[00181] To a solution of isopropyl 4-(4-chloro-leta-pyrazolo[3,4-d]pyrimidin-l- yl)piperidine- 1 -carboxylate from Example 19C (63 mg, 0.195 mmol) in 2 mL of DMF was added 3-hydroxypicolinonitrile (23.37 mg, 0.195 mmol) and potassium carbonate (53.8 mg, 0.389 mmol). The reaction was allowed to stir at room temperature for 18 h. The reaction was diluted with ethyl acetate, washed with sat’d aq sodium bicarbonate and brine, dried over MgSO4, filtered through a pad of silica gel and concentrated in vacuo to an oil. The residue was purified by silica gel chromatography (12 g ISCO cartridge, 0-90% ethyl acetate/hexane, 15 min gradient) to afford Example 19 (24 mg, 29%) as an off-white solid. 1H NMR (500 MHz, CDCl3) delta ppm 1.29 (d, J=6.05 Hz, 6 H) 2.02 – 2.08 (m, 2 H) 2.25 – 2.35 (m, 2 H) 2.98 – 3.08 (m, 2 H) 4.38 (s, 2 H) 4.94 – 5.05 (m, 2 H) 7.68 (dd, J=8.52, 4.67 Hz, 1 H) 7.88 (d, J=8.80 Hz, 1 H) 8.27 (s, 1 H) 8.49 (s, 1 H) 8.69 (d, J=4.40 Hz, 1 H). LRMS (ESI): 408.3 (M+H)+.

The synthetic route of 932-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/137436; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 932-35-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 932-35-4, name is 3-Hydroxypicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 3-hydroxypyridine-2-carbonitrile d (10 mmol, 1.2 g), chloroacetone (1 equiv. , 10 mmol, 0.93 g) and potassium carbonate (1 equiv., 10 mmol, 1.38 g) in DMF (30 ml) was heated at 80C overnight. The reaction mixture was poured into ice-water (200 ml) and the precipitate was filtered off and dried to afford intermediate e (1.4 g, yield = 80%, purity (LC) > 95%). To a stirred mixture of intermediate e (7.9 mmol, 1.39 g) and cyanoacetic acid (1 equiv. , 7.9 mmol, 0.675 g) in DMF (20 ml) was added EDCI (1 equiv. , 7.9 mmol, 1.51 g) and the reaction mixture was stirred overnight at room temperature. The mixture was poured into ice-water (150 ml) causing a precipitation. The solid was filtered off and dried by co-evaporation with tetrahydrofuran and then with toluene. The residue was mixed with isopropanol (15 ml) and ethyl-diisopropylamine (1 equiv., 7.9 mmol, 1.02 g) and heated to 80C during 4h. After cooling to room temperature, a solid was filtered off affording intermediate f (1.35 g, yield = 76%, purity (LC) > 95%). A mixture of intermediate f (1.0 mmol, 0.225 g), copper (II) acetate(2 equiv. , 2.0 mmol, 0.363 g), 4-nitrophenylboronic acid (2.0 equiv. , 2.0 mmol, 0.334 g), triethyl- amine (2.0 equiv. , 2.0 mmol, 0.202 g) and pyridine (2.0 equiv. , 2.0 mmol, 0.158 g) in dichloromethane (5 ml) was stirred overnight at room temperature in a reaction vial provided with a calcium chloride tube. The reaction mixture was dilluted with dichloromethane (50 ml), washed with water, dried (MgS04), filtered and evaporated under reduced pressure. The crude compound was purified by chromatography (silica gel, eluent: 2% methanol in dichloromethane) to afford compound 3 (30 mg, yield = 8 %, purity (LC) = 82 %).

According to the analysis of related databases, 932-35-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TIBOTEC PHARMACEUTICALS Ltd.; WO2005/111044; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 932-35-4 ,Some common heterocyclic compound, 932-35-4, molecular formula is C6H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(1) 2-Cyano-3-hydroxypyridine (3.00 g) is dissolved in acetonitrile/water (5:1, 90 ml), and N-bromosuccinic imide (5.34 g) is added thereto in small portions under ice-cooling. The mixture is then stirred for 2 hours under the same cooling conditions. The reaction solution is diluted with ethyl acetate, washed with water and saturated brine successively and dried over sodium sulfate. The solvent is removed by evaporation under reduced pressure to give crude 6-bromo-3-hydroxypyridine-2-carbonitrile (6.26 g). ESI-MS M/Z:197/ 199[M-H]-.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,932-35-4, its application will become more common.

Reference:
Patent; TANABE SEIYAKU CO., LTD.; EP1582521; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 932-35-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 932-35-4, name is 3-Hydroxypicolinonitrile. A new synthetic method of this compound is introduced below.

(1) A suspension prepared by adding 2.73 g of 2-cyano-3-hydroxypyridine to 60 mL of a mixed solution of acetonitrile/water=5/1 was cooled to 0 C. A reaction mixture prepared by adding 4.85 g of N-bromosuccinimide slowly to the suspension was stirred for 2 hours under a nitrogen atmosphere. Water was added to the reaction mixture, which was then extracted with ethyl acetate. The organic layer was washed with brine, then dried, and concentrated in vacuo to give 5.39 g of a crude product of 6-bromo-2-cyano-3-hydroxypyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,932-35-4, 3-Hydroxypicolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; TEIJIN PHARMA LIMITED; KAWANA, Asahi; KANAZAWA, Chikashi; TERA, Masayuki; TAKAHASHI, Yoshimasa; IMAZEKI, Mariko; TAKAHASHI, Hiroyuki; TANOKURA, Akira; (51 pag.)US2016/39784; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 932-35-4, name is 3-Hydroxypicolinonitrile, the common compound, a new synthetic route is introduced below. Quality Control of 3-Hydroxypicolinonitrile

Reference Example 23: N-(5-chloropyridin-2-yl)-2-[(2-cyanopyridin-3-yl)oxy]acetamide; [] 2-Cyano-3-hydroxypyridine (35.0 g) obtained according to the method described in a literature (Synthesis 1983, 316) is dissolved in acetone (800 ml), and thereto are added 2-chloro-N-(5-chloropyridin-2-yl)acetamide (62.6 g) obtained in Reference Example 21, potassium carbonate (60.0 g) and sodium iodide (45.8 g). The mixture is then heated under reflux for 2 hours. After allowing to cool, water and ethyl acetate are poured to the reaction mixture, and the insoluble materials are removed by filtration. The organic layer is then separated. The aqueous layer is extracted with ethyl acetate and the organic layers are combined, washed with saturated brine and dried over sodium sulfate. The solvent is removed by evaporation under reduced pressure and the resulting residue is suspended in diethyl ether. The precipitates are collected by filtration to give the title compound (80.3 g). APCI-MS M/Z:289/291[M+H]+.

The synthetic route of 932-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TANABE SEIYAKU CO., LTD.; EP1582521; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

932-35-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 932-35-4, name is 3-Hydroxypicolinonitrile. A new synthetic method of this compound is introduced below.

Example 4: At room temperature, 2-cyano-3-hydroxypyridine 0.46 g was added to a three-necked flask. Under a nitrogen atmosphere, 3.0 ml of toluene and 1.31 g of phosphorus pentachloride were added at a bath temperature of 120 C for 10 hours. The mixture was allowed to cool to 70 C and water was added to the solution and the aqueous layer was extracted with toluene. The organic layer thus obtained was washed with saturated aqueous sodium hydrogencarbonate solution and concentrated under reduced pressure to obtain 8.28 g of a solution containing 0.27 g of 2-cyano-3-chloropyridine. The yield of 2-cyano-3-chloropyridine was 50% based on 2-cyano-3-hydroxypyridine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 932-35-4, 3-Hydroxypicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WAKAMATSU, TAKAYUKI; NAGASHIMA, YUTA; IMOTO, RIKA; (24 pag.)TW2016/510; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

932-35-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 932-35-4, name is 3-Hydroxypicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 76A 3-Amino-2-carbomethoxyfuro[2,3-b]pyridine 2-Cyano-3-hydroxypyridine (1.2 g, 10 mmol), prepared as described in Synthesis 316 (1983), was aedded in portions to a 0 C. suspension of NaH (0.4 g of 60% dispersion, 10 mmol) in DMF (5 mL). After stirring for 20 min at 0 C., ethyl bromoacetate was added dropwise. The reaction was stirred for 30 min at 25 C. and was the poured into ice water. The resulting solid was collected by filtration and was washed with a small portion of water. The crude ethyl ester was taken up in EtOAc, dried (MgSO4), filted, and concentrated (1.16 g obtained). To the pyridine (1.0 g, 5.0 mmol) in THF (20 mL) was added potassium t-butoxide (0.56 g, 5.0 mmol). After stirring for 45 min, the reaction was partitioned between EtOAc and NaHCO3 solution. The layers were seperated and the aqueous layer was extracted with EtOAc (2x). The combined organic layers were washed with brine, dried (MgSO4), filtered, and concentrated to provide 0.76 g (76%) of the title compound: 1 H NMR (300 MHz, CDCl3) delta1.46 (t, 3H), 4.47 (q, 2H), 5.21 (bs, 2H), 7.38 (dd, 1H), 7.76 (dd, 1H), 8.56 (dd, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 932-35-4, 3-Hydroxypicolinonitrile.

Reference:
Patent; Abbott Laboratories; US5597823; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem