Category: 934180-48-0

Synthetic Route of 934180-48-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 934180-48-0, name is 4-Chloro-2-methoxy-3-nitropyridine. A new synthetic method of this compound is introduced below.

General procedure: To a soln. of 1-fluoro/chloro-2-nitro-(hetero)arene (BB-2, 1 eq) and Boc-protected diamine (BB-1 , 1 to 1.2 eq) in DMSO (1.5 mL/mmol) was added DIPEA (2 eq) and the soln. was heated at a given temperature for a given time (see Table 16). The rxn mixture was partitioned between EtOAc and water. The org. phase was washed with water (4x) and with brine, dried over MgS04 and concentrated in vacuo. The crude was purified by CC using Hept/EtOAc and/or DCM/MeOH.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,934180-48-0, 4-Chloro-2-methoxy-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (188 pag.)WO2019/141803; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 934180-48-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 934180-48-0, name is 4-Chloro-2-methoxy-3-nitropyridine. A new synthetic method of this compound is introduced below.

General procedure: To a soln. of 1-fluoro/chloro-2-nitro-(hetero)arene (BB-2, 1 eq) and Boc-protected diamine (BB-1 , 1 to 1.2 eq) in DMSO (1.5 mL/mmol) was added DIPEA (2 eq) and the soln. was heated at a given temperature for a given time (see Table 16). The rxn mixture was partitioned between EtOAc and water. The org. phase was washed with water (4x) and with brine, dried over MgS04 and concentrated in vacuo. The crude was purified by CC using Hept/EtOAc and/or DCM/MeOH.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,934180-48-0, 4-Chloro-2-methoxy-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (188 pag.)WO2019/141803; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 934180-48-0, Adding some certain compound to certain chemical reactions, such as: 934180-48-0, name is 4-Chloro-2-methoxy-3-nitropyridine,molecular formula is C6H5ClN2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 934180-48-0.

Tin(II)chloride dihydrate (12 g, 53.19 mmol) was added to a solution of 4-chloro-2-methoxy-3-nitropyridine (2 g, 10.64 mmol) in ethyl acetate (30 mL) and the resultant suspension heated at 70 C. with stirring for 2 h. The reaction mixture was cooled to ambient temperature, the pH adjusted to pH 9-10 by addition of saturated sodium carbonate (aq.) and extracted with ethyl acetate (3 100 mL). The combined extracts were dried (MgSO4) and concentrated in vacuo to give the crude product. Purification by chromatography on silica gel with EtOAc:heptane (1:9, v/v) as eluent afforded the product as a colourless oil (1.28 g, 76%).Data for 3-amino-4-chloro-2-methoxypyridine: MS (ESI) m/z:159/161 ([M+H]+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 934180-48-0, 4-Chloro-2-methoxy-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; N.V. Organon; US2007/112019; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 934180-48-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.934180-48-0, name is 4-Chloro-2-methoxy-3-nitropyridine, molecular formula is C6H5ClN2O3, molecular weight is 188.57, as common compound, the synthetic route is as follows.

Tin(ll)chloride dihydrate (12 g, 53.19 mmol) was added to a solution of 4-chloro-2- methoxy-3-nitropyridine (2 g, 10.64 mmol) in ethyl acetate (30 ml.) and the resultant suspension heated at 70 C with stirring for 2 h. The reaction mixture was cooled to ambient temperature, the pH adjusted to pH 9-10 by addition of saturated sodium carbonate (aq.) and extracted with ethyl acetate (3 x 10OmL). The combined extracts were dried (MgSO4) and concentrated in vacuo to give the crude product. Purification by chromatography on silica gel with EtOAc:heptane (1 :9, v/v) as eluent afforded the product as a colourless oil (1.28 g, 76 %).Data for 3-amino-4-chloro-2-methoxypyridine: MS (ESI) m/z: 159/161 ([M+H]+).

The chemical industry reduces the impact on the environment during synthesis 934180-48-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; N.V. ORGANON; WO2007/39563; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 934180-48-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 934180-48-0, name is 4-Chloro-2-methoxy-3-nitropyridine, molecular formula is C6H5ClN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-chloro-5-cyanophenol (4.73 g, 1.00 equiv) and potassium carbonate (8.52 g, 2.00 equiv) were added to a solution of nitro compound from the previous step (5.81 g, 30.8 mmol) in DMF (90 mL). After heating for 20 hrs at 50 C. the reaction mixture was cooled to rt, and poured into water (500 mL). The mixture was extracted with ether, washed with water and brine, dried over MgSO4, and concentrated in vacuo to give crude material (10 g) which was carried on to the next step.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 934180-48-0, 4-Chloro-2-methoxy-3-nitropyridine.

Reference:
Patent; Roche Palo Alto LLC; US2010/56535; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem