Category: 934266-82-7

Reference of 934266-82-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.934266-82-7, name is 5-Bromothiazolo[5,4-b]pyridin-2-amine, molecular formula is C6H4BrN3S, molecular weight is 230.09, as common compound, the synthetic route is as follows.

Step 2: tert-Butyl 5-bromothiazolo[5,4-b]pyridin-2-ylcarbamate To a suspension of 5-bromothiazolo[5,4-b]pyridin-2-amine (15.0 g, 65.1 mmol) in DCM (300 mL) was added di-tert butyl dicarbonate (21.0 g, 96.2 mmol) and 4-dimethylaminopyridine (8 g, 65.5 mmol). The reaction mixture stirred at room temperature for 2 h and evaporated in vacuo. The residue was purified via flash chromatography on silica gel (solvent gradient: 0-50% ethyl acetate in petroleum ether) to yield 13 g (60%) of the title compound as a white solid. LCMS (ESI): [M+H]+=330/332.

Statistics shows that 934266-82-7 is playing an increasingly important role. we look forward to future research findings about 5-Bromothiazolo[5,4-b]pyridin-2-amine.

Reference:
Patent; Genentech, Inc.; Braun, Marie-Gabrielle; Garland, Keira; Hanan, Emily; Purkey, Hans; Staben, Steven T.; Heald, Robert Andrew; Knight, Jamie; Macleod, Calum; Lu, Aijun; Wu, Guosheng; Yeap, Siew Kuen; (183 pag.)US2018/65983; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 934266-82-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 934266-82-7, name is 5-Bromothiazolo[5,4-b]pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

Step B: 4-acetylbenzoyl chloride (3B, 560 mg, 1.0 equivalent) was dissolved in DMA (0.15 M). Methyl 4-(chlorocarbonyl)benzoate (2.0 equivalent) was then added. The mixture was heated to 50 C. for 12 h, followed by addition of water and extraction with EtOAc twice. The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo. The crude product was purified by chromatography (SiO2, gradient of 5 to 20% EtOAc/Hex) to give 3C (16%) as a tan solid: 1H NMR (400 MHz, DMSO-d6) delta ppm 2.66 (s, 3 H) 7.73 (d, J=8.59 Hz, 1H) 8.08-8.17 (m, 3H) 8.25 (d, J=8.84 Hz, 2H) 13.36 (br. s., 1H); ESI-MS: m/z 376.0 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 934266-82-7, 5-Bromothiazolo[5,4-b]pyridin-2-amine.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/318425; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem