Category: 936841-69-9

Reference of 936841-69-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 936841-69-9, name is 4-(Trifluoromethyl)picolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-(trifluoromethyl)pyridine-2-carbonitrile (500 mg, 3.0 mmol) in 10 ml ethanol was added hydroxylammonium chloride (302 mg, 4.0 mmol) and triethylamine (382 mg, 4.0 mmol) and then the reaction mixture was stirred 13 h at 50 C. After cooling to RT, the solvent was evaporated and the crude was solved in dichloromethane and extracted with water. The organic phase was dried over magnesium sulfate, filtered and evaporated under vacuum to yield the title compound (432 mg, 65 % of theory, 90 % purity). The compound was used without further purification. LC-MS (method 2B): RT = 1.78 min, m/z = 206 (M+H)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 936841-69-9, 4-(Trifluoromethyl)picolinonitrile.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ELLERMANN, Manuel; VALOT, Gaelle; CANCHO GRANDE, Yolanda; HAssFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; BEYER, Kristin; ROeHRIG, Susanne; SPERZEL, Michael; STAMPFUss, Jan; MEYER, Imke; KOeLLNBERGER, Maria; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; HEIERMANN, Joerg; HENGEVELD, Willem Jan; (764 pag.)WO2016/71216; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 936841-69-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 936841-69-9, name is 4-(Trifluoromethyl)picolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-(trifluoromethyl)pyridine-2-carbonitrile (500 mg, 3.0 mmol) in 10 ml ethanol was added hydroxylammonium chloride (302 mg, 4.0 mmol) and triethylamine (382 mg, 4.0 mmol) and then the reaction mixture was stirred 13 h at 50 C. After cooling to RT, the solvent was evaporated and the crude was solved in dichloromethane and extracted with water. The organic phase was dried over magnesium sulfate, filtered and evaporated under vacuum to yield the title compound (432 mg, 65 % of theory, 90 % purity). The compound was used without further purification. LC-MS (method 2B): RT = 1.78 min, m/z = 206 (M+H)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 936841-69-9, 4-(Trifluoromethyl)picolinonitrile.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ELLERMANN, Manuel; VALOT, Gaelle; CANCHO GRANDE, Yolanda; HAssFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; BEYER, Kristin; ROeHRIG, Susanne; SPERZEL, Michael; STAMPFUss, Jan; MEYER, Imke; KOeLLNBERGER, Maria; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; HEIERMANN, Joerg; HENGEVELD, Willem Jan; (764 pag.)WO2016/71216; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 936841-69-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 936841-69-9, name is 4-(Trifluoromethyl)picolinonitrile, molecular formula is C7H3F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of the product from Step B (1.3 g, crude) in a mixed solvent of HC1 (conc.) and dioxane (20 mL, 1:1) was refluxed for 2 hours. The mixture was concentrated to obtain the titleproduct (350 mg, 60% for 2 steps) as a brown solid which was used for the next step without any further purification. MS: MIe 192 (M+1).

According to the analysis of related databases, 936841-69-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BEIGENE, LTD.; ZHOU, Changyou; ZHANG, Guoliang; WO2014/206344; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 936841-69-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 936841-69-9, name is 4-(Trifluoromethyl)picolinonitrile, molecular formula is C7H3F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of the product from Step B (1.3 g, crude) in a mixed solvent of HC1 (conc.) and dioxane (20 mL, 1:1) was refluxed for 2 hours. The mixture was concentrated to obtain the titleproduct (350 mg, 60% for 2 steps) as a brown solid which was used for the next step without any further purification. MS: MIe 192 (M+1).

According to the analysis of related databases, 936841-69-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BEIGENE, LTD.; ZHOU, Changyou; ZHANG, Guoliang; WO2014/206344; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 936841-69-9, name is 4-(Trifluoromethyl)picolinonitrile, molecular formula is C7H3F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 4-(Trifluoromethyl)picolinonitrile

To 72 ml of ethanol were added 6.18 g of sodium bicarbonate and 5.1 1 g of hydroxylamine hydrochloride, and the mixture was heated to reflux for 45 minutes. After allowing to cool, 6 g of 2-cyano-4-trifluoromethylpyridine was added at 0C, and the mixture was stirred, and concentrated. To the residue was added water, the resultant solution was extracted with ethyl acetate three times, and the organic layers were combined, washed with an aqueous saturated sodium chloride solution, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography to obtain 5 g of 4-trifluoromethylpyridine-2- carboxamide=oxime. 4-Trifluoroemthylpyridine-2-carboxamide=oxime 1H-NMR (DMSO-d6): 6.00 (bs, 2H), 7.80 (d, IH), 8.06 (s, IH), 8.86 (d, IH), 10.19 (s, IH)

With the rapid development of chemical substances, we look forward to future research findings about 936841-69-9.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/66786; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 936841-69-9, name is 4-(Trifluoromethyl)picolinonitrile, the common compound, a new synthetic route is introduced below. Quality Control of 4-(Trifluoromethyl)picolinonitrile

To a solution of 4-(trifluoromethyl)pyridine-2-carbonitrile (0.516 g, 3.00 mmol) in methanol (4.5 ml) was added sodium methoxide (30 wt% in MeOH) (0.027 g, 0.150 mmol, 0.028 ml). The mixture was stirred at room temperature for 3 h. The solution was transferred into a reaction vial, methylamine (33 wt% inEtOH) (1.512 g, 16.07 mmol, 2.0 ml) was added, the vial was closed and the mixture was heated at60C overnight. Hydrochloric acid (4M in dioxane) (3.00 mmol, 0.750 ml) was added and heating was continued at 90C for 2 h. The reaction mixture was concentrated. In a reaction vial, the residue was redissolved in methylamine (33 wt% in EtOH) (7.56 g, 80 mmol, 10.00 ml), hydrochloric acid (4M in dioxane) (3.00 mmol, 0.750 ml) was added, the vial was capped and the mixture was heated at 90Covernight. The reaction mixture was concentrated and the residue partitioned between diethyl ether and sat. Na2CO3 (aq). After washing and separation of the phases, the aqueous layer was extracted with ether two more times. The combined organic layers were dried over sodium sulfate and concentrated. The residue was purified over silica by flash column chromatography (0-100% B in A; A: CH2CI2 B: CH2CI2/MeOH/Et3N, 9/1/0.1). The fractions containing product were combined andconcentrated. The residue was dissolved in methanol and hydrochloric acid in dioxane (4M, 2 ml) was added. The mixture was concentrated, coevaporated with methanol and twice with diethyl ether to afford the title compound (484 mg) as a solid. LCMS (method 1): 218 (M+H), retention time 1.47 mm. 1H-NMR (DMSO-d6, ppm) 2.86 (3H), 3.06 (3H), 8.15 (1H), 8.29 (1H), 9.09 (1H), 9.87 (1H), 10.23 (1H).

The synthetic route of 936841-69-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; MUEHLEBACH, Michel; TITULAER, Ruud; EMERY, Daniel; EDMUNDS, Andrew; STOLLER, Andre; JUNG, Pierre Joseph Marcel; BUCHHOLZ, Anke; RENOLD, Peter; (98 pag.)WO2015/144826; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 936841-69-9 ,Some common heterocyclic compound, 936841-69-9, molecular formula is C7H3F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0209] A mixture of 4-(trifluoromethyl)picolinonitrile (840mg, 4.88 mmol) and 10%Pd/C (168 mg, 0.16 mmol) was stirred under hydrogen (balloon) in MeOH (10 mL) at ambient temperature for overnight. The reaction mixture was filtered through Celite and concentrated to afford (4- (trifluorom ethyl )pyridin-2-yl)methanamine as an oil. LC/MS = 177 [M+l].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,936841-69-9, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUANG, Rongze; TING, Pauline; ALI, Amjad; WU, Heping; BERLIN, Michael; STAMFORD, Andrew; WANG, Hongwu; ZHOU, Gang; KIM, David; DENG, Qiaolin; LIM, Yeon-Hee; YU, Younong; (201 pag.)WO2016/81290; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 936841-69-9 ,Some common heterocyclic compound, 936841-69-9, molecular formula is C7H3F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0209] A mixture of 4-(trifluoromethyl)picolinonitrile (840mg, 4.88 mmol) and 10%Pd/C (168 mg, 0.16 mmol) was stirred under hydrogen (balloon) in MeOH (10 mL) at ambient temperature for overnight. The reaction mixture was filtered through Celite and concentrated to afford (4- (trifluorom ethyl )pyridin-2-yl)methanamine as an oil. LC/MS = 177 [M+l].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,936841-69-9, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUANG, Rongze; TING, Pauline; ALI, Amjad; WU, Heping; BERLIN, Michael; STAMFORD, Andrew; WANG, Hongwu; ZHOU, Gang; KIM, David; DENG, Qiaolin; LIM, Yeon-Hee; YU, Younong; (201 pag.)WO2016/81290; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 936841-69-9, 4-(Trifluoromethyl)picolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 936841-69-9, blongs to pyridine-derivatives compound. Computed Properties of C7H3F3N2

To 4-trifluoromemyl-2-pyridinecarbonitrile (262 mg, 1.52 mmol) was added a solution of sodium methoxide in methanol (0.1 M, 1.5 ml, 0.1 eq.) and the solution heated under nitrogen in a 40-45 C oil-bath for 105 min. A solution of 2-amino-4-(5′-(4″- methylpiperazin- 1 “-yl)benzimida7ol-2′-yl)aniline (295 mg, 0.92 mmol) in dry methanol (15 ml) and glacial acetic acid (0.18 ml, 3.1 mmol) was then added and the mixture gently refluxed under nitrogen for 19 h. After cooling the solvents were removed by rotary evaporator, the residue dissolved in water (10 ml) and basified to pH 8 with dilute ammonia solution (3.0 M). The oily precipitate was stirred for 40 min to give a friable light brown suspension that was centrifuged and the supernatant removed. Then solid was then treated with water (3 x 8 ml), followed by acetonitrile (3 x 4 ml) with centrifuging and removal of the supernatant between treatments. The remaining solid was dried under vacuum to give a dull yellow powder (358 mg). A portion of this material (250 mg) was dissolved in methanol (1-2 ml) and applied to a silica cartridge (KP-Sil 25g) and eluted with methanol to give 2-(5 ‘-(5”-(4’ ‘ ‘-methylpiperazin- 1 ‘ “-yl)ben/imidayol-2″- yl)benzimidaz»l-2’-yl)-4-(trifluoromemyl)pyridine as a yellow powder (236 mg, 77%), mp 203-208 C. nmr (400 MHz, dj-MeOH + 5 drops d-TFA) delta 3.01, s, 3H, 4″‘-MeN; 3.21, t (J =12.0 Hz), 2H, NCH2; 3.35, m (obs), NCH2; 3.68, d ( J = 12.0 Hz), 2H, NCH2; 3.96, d (J = 13.6 Hz), 2H, NCH2; 7.32, d (J = 2.0 Hz), 1H, H4″; 7.41, dd (J = 2.5, 9.2 Hz), 1H, H6″; 7.73, d (J = 8.8 Hz), 1H, H7″; 7.88, m, 1H, H5; 8.01, dd (J = 0.6, 8.6 Hz), 1H, H7′; 8.09, dd (J = 2.5, 8.8 Hz), 1H, H6′; 8.52, m, 1H, H4’; 8.66, s, 1H, H3; 9.05, d (J = 4.8 Hz), 1H, H6. ,3C nmr (125 MHz, dj-MeOH + 5 drops HOAc) delta 43.6, 4″‘-MeN; 49.4, C2″76″‘; 54.7, C3″75′”; 102.7, C4″; 115.4, 116.4, 116.8, 117.1, C4 C6″, C7 CT; 118.0, 121.2, C3, C5; 123.4, C6’; 124.1, q (‘JCF = 273 Hz), 4-F3C; 124.9, C5′; 134.6, C7a”; 139.2, C3a’ or C3a”; 140.3, d (2JCF = 34 Hz), C4; 140.5, C3a” or C3a’; 141.4, C7a’; 148.5, C5″; 150.2, C2; 152.2, C6; 152.7, 152.9, C2 C2″. MS (ESI +ve) m/z 478 (MH+, 100%). HRMS (ESI +ve) m/z 478.19599, C25H23F3N7 requires 478.19615 (Delta = 0.3 ppm).Cytotoxicity and radioprotection resultsC50 = 23.3PF = 63.8DMFm = 2.75DMF10 = 2.58

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,936841-69-9, its application will become more common.

Reference:
Patent; PETER MACCALLUM CANCER INSTITUTE; MARTIN, Roger, Francis; WHITE, Jonathan; LOBACHEVSKY, Pavel; WINKLER, David; SKENE, Colin; MARCUCCIO, Sebastian; WO2011/123890; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 936841-69-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 936841-69-9 as follows.

To a solution of 4-(trifluoromethyl)pyridine-2-carbonitrile (1.7 g, 9.88 mmol) in methanol (18 ml) was added sodium methoxide (25 wt% in MeOH) (2.1 g, 9.9 mmol, 2.3 ml) and the mixture stirred at room temperature for 3 hours. The reaction mixture was concentrated to dryness, the residue suspended in methylamine (33 wt% in EtOH) (25 ml, 200.9 mmol) to which was added methylamine hydrochloride (6.7 g, 99.2 mmol). The reaction mixture was heated in a closed high pressure vial at 90C overnight. After cooling, the mixture was concentrated and the residue treated with dichloromethane, filtered and the filtrate evaporated under reduced pressure. This material was dissolved in diethyl ether, treated with a 2M hydrochloric acid solution in diethyl ether under cooling, stirred at 5-10C for 20 minutes, then diluted with water. The layers were separated and the organic phase washed twice with water. The combined aqueous phases were basified to pH 12 by addition of an aqueous 30% sodium hydroxide solution under cooling, and the product thoroughly extracted with diethyl ether (4x). The combined organic layers were dried over sodium sulfate and concentrated under reduced pressure to afford N,N’-dimethyl-4-(trifluoromethyl)pyridine-2-carboxamidine as an oil (0.70 g), which was used without further purification. LCMS (method 1 ): 218 (M+H)+, retention time 0.28 min. 9F-NMR (MeOD, ppm) -66.4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,936841-69-9, its application will become more common.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; MUEHLEBACH, Michel; JUNG, Pierre, Joseph, Marcel; EDMUNDS, Andrew; EMERY, Daniel; BUCHHOLZ, Anke; (145 pag.)WO2017/16910; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem