As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 936841-73-5, name is 5-Fluoro-2-(trifluoromethyl)pyridine, molecular formula is C6H3F4N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 936841-73-5
A solution of ethyl 3-amino-1H-pyrazole-4-carboxylate (1.55 g, 0.01 mol), 5-fluoro-2- (trifluoromethyl)pyridine (1.65 g, 0.01 mol), C52CO3(4.89 g, 0.015 mol) in DMF (8 mL) was stirred for 1 hour at 100 C. The mixture was diluted with water, extracted with EA (x3). The organic layers were combined and washed with brine (x2), dried, concentrated. The cmde product was purified via silica gel chromatography (PE-EA) to give the mixture of desired compounds as ayellow solid (1.04 g, 35%). ESI MS m/z = 301.1[M+Hjt
With the rapid development of chemical substances, we look forward to future research findings about 936841-73-5.
Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; SHOOK, Brian, C.; KIM, In, Jong; BLAISDELL, Thomas, P.; YU, Jianming; PANARESE, Joseph; OR, Yat, Sun; (434 pag.)WO2017/15449; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem