Category: 941294-57-1

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 941294-57-1, name is 5-Bromo-2-iodo-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H5BrIN

Step B: 5-Bromo-4-methyl-pyridine-2-carbaldehyde In an oven-dried flask the compound obtained in Step A (4.67 g) was dissolved in tetrahydrofuran (22 ml). The solution was cooled to -15 C., then isopropyl magnesium bromide (17.2 ml, 15% solution in THF) was added dropwise at a rate to keep the internal temperature between -15 C. to -10 C. The reaction was stirred at this temperature for 1 hour, then anhydrous dimethylformamide (1.8 ml) was added at a rate to keep the internal temperature below 0 C. The reaction was stirred at this temperature for 1 hour, then poured into water and extracted with diethyl ether. The organic layer was dried over sodium sulfate and concentrated in vacuo. The crude title aldehyde product (2.4 g, brown solid) was used as such in the next step.

With the rapid development of chemical substances, we look forward to future research findings about 941294-57-1.

Reference:
Patent; SYNGENTA CROP PROTECTION LLC; US2012/238517; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 941294-57-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.941294-57-1, name is 5-Bromo-2-iodo-4-methylpyridine, molecular formula is C6H5BrIN, molecular weight is 297.92, as common compound, the synthetic route is as follows.

To a suspension of 5-bromo-2-iodo-4-methylpyridine(1g, 3.36 mmol) in NMP (6mL) with an inert atmosphere of argon, KF (0.585 g, 10.07 mmol), Cul (1.92 g, 10.08 mmol) and CF3SiMe3 (2.49 mL, 15.07 mmol) were added. The resulting solution was stirred overnight at 60C. After cooling, the mixture was poured into 12% aqueous ammonia, and then extracted with Et2O. The organic solutions were combined, dried over MgSO4, filtered and concentrated. Purification of the crude residue by normal phase chromatography (0% to 100%, hexane – diethyl ether) afforded the desired product (23% yield) as a yellow oil.

Statistics shows that 941294-57-1 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2-iodo-4-methylpyridine.

Reference:
Patent; Almirall, S.A.; Vidal Juan, Bernat; Gonzalez Rodriguez, Jacob; Gual Roig, Silvia; Esteve Trias, Cristina; Vidal Gispert, Laura; EP2738172; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem