Category: 94170-15-7

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 94170-15-7, name is 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, the common compound, a new synthetic route is introduced below. Safety of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde

Intermediate 2-11 (30 mg, 0.087 mmol) was dissolved in DCM (2 mL)4-Aldehyde-1-methylpyridine-2(1H)-one (14.3 mg, 0.104 mmol), NaBH (OAc) 3 (46.1 mg, 0.218 mmol).Stir at room temperature overnight.TLC monitors the reaction,Add saturated aqueous sodium bicarbonate (5 mL),Extracted with DCM (3 x 10 mL),Combine the organic phase,Wash with water (2 × 5mL),Dry over anhydrous sodium sulfate,filter,concentrate,The crude product was purified by silica gel column chromatography (DCM: MeOH=200:1-20:1)White solid (5.8 mg, yield: 14.5%).

The synthetic route of 94170-15-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 94170-15-7, name is 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, the common compound, a new synthetic route is introduced below. Safety of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde

Intermediate 2-11 (30 mg, 0.087 mmol) was dissolved in DCM (2 mL)4-Aldehyde-1-methylpyridine-2(1H)-one (14.3 mg, 0.104 mmol), NaBH (OAc) 3 (46.1 mg, 0.218 mmol).Stir at room temperature overnight.TLC monitors the reaction,Add saturated aqueous sodium bicarbonate (5 mL),Extracted with DCM (3 x 10 mL),Combine the organic phase,Wash with water (2 × 5mL),Dry over anhydrous sodium sulfate,filter,concentrate,The crude product was purified by silica gel column chromatography (DCM: MeOH=200:1-20:1)White solid (5.8 mg, yield: 14.5%).

The synthetic route of 94170-15-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 94170-15-7, name is 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde. A new synthetic method of this compound is introduced below., Recommanded Product: 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde

(i) Ethyl beta-(N-methyl-2-oxo-4-pyridyl)acrylate N-Methyl-4-formyl-2-pyridone* (30.17 g), monoethyl malonate (38.15 g), pyridine (150 ml) and piperidine (3 ml) were stirred under reflux for 61/2 hours. The reaction mixture was evaporated under reduced pressure to afford a residue which was crystallized from aqueous isopropanol to give ethyl beta-(N-methyl-2-oxo-4-pyridyl)acrylate as a pale yellow solid (18.44 g), m.p. 126-7 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 94170-15-7, 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4540699; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 94170-15-7, name is 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, molecular formula is C7H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C7H7NO2

1- (1,1-dioxotetrahydro-2H-thian-4-yl) -6-((trans) -4-methylpyrrolidin-3-yl) -1,5-dihydro -4H-pyrazolo [3,4-d] pyrimidin-4-one trifluoroacetate (97mg, 0.21mmol, 1.0eq),1-methyl-2-oxo-1,2-dihydropyridine-4-carboxaldehyde (34.2 mg, 0.25 mmol, 1.2 eq)And acetic acid (25mg, 0.42mmol, 2.0eq) were dissolved in methanol (5mL), heated to 45 C for 2h,Cool down to 0 ,Add sodium cyanoborohydride (39.2 mg, 0.63 mmol, 3.0 eq) and stir at this temperature for 2 h.TLC monitoring showed no complete reaction,Additional 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxaldehyde (114.3mg, 0.83mmol, 4.0eq) was added and stirred at this temperature for 2h,Add cyanoborohydride (39.2mg, 0.63mmol, 3.0eq), and react at 45 C for 2h.TLC monitoring showed complete reaction,Concentrated under reduced pressure, added saturated aqueous sodium carbonate (10 mL) and saturated brine (10 mL), and extracted with dichloromethane (50 mL x 4). The organic phases were combined, dried, filtered, and concentrated.The crude product was purified by preparative thin layer chromatography (MeOH: DCM = 1: 20)The product was obtained as an off-white solid (59 mg, yield: 45.6%).

With the rapid development of chemical substances, we look forward to future research findings about 94170-15-7.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Peng Peng; Li Lin; (59 pag.)CN110357888; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 94170-15-7, name is 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde. A new synthetic method of this compound is introduced below., Recommanded Product: 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde

(i) Ethyl beta-(N-methyl-2-oxo-4-pyridyl)acrylate N-Methyl-4-formyl-2-pyridone* (30.17 g), monoethyl malonate (38.15 g), pyridine (150 ml) and piperidine (3 ml) were stirred under reflux for 61/2 hours. The reaction mixture was evaporated under reduced pressure to afford a residue which was crystallized from aqueous isopropanol to give ethyl beta-(N-methyl-2-oxo-4-pyridyl)acrylate as a pale yellow solid (18.44 g), m.p. 126-7 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 94170-15-7, 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4540699; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 94170-15-7, name is 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, molecular formula is C7H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C7H7NO2

1- (1,1-dioxotetrahydro-2H-thian-4-yl) -6-((trans) -4-methylpyrrolidin-3-yl) -1,5-dihydro -4H-pyrazolo [3,4-d] pyrimidin-4-one trifluoroacetate (97mg, 0.21mmol, 1.0eq),1-methyl-2-oxo-1,2-dihydropyridine-4-carboxaldehyde (34.2 mg, 0.25 mmol, 1.2 eq)And acetic acid (25mg, 0.42mmol, 2.0eq) were dissolved in methanol (5mL), heated to 45 C for 2h,Cool down to 0 ,Add sodium cyanoborohydride (39.2 mg, 0.63 mmol, 3.0 eq) and stir at this temperature for 2 h.TLC monitoring showed no complete reaction,Additional 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxaldehyde (114.3mg, 0.83mmol, 4.0eq) was added and stirred at this temperature for 2h,Add cyanoborohydride (39.2mg, 0.63mmol, 3.0eq), and react at 45 C for 2h.TLC monitoring showed complete reaction,Concentrated under reduced pressure, added saturated aqueous sodium carbonate (10 mL) and saturated brine (10 mL), and extracted with dichloromethane (50 mL x 4). The organic phases were combined, dried, filtered, and concentrated.The crude product was purified by preparative thin layer chromatography (MeOH: DCM = 1: 20)The product was obtained as an off-white solid (59 mg, yield: 45.6%).

With the rapid development of chemical substances, we look forward to future research findings about 94170-15-7.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Peng Peng; Li Lin; (59 pag.)CN110357888; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 94170-15-7, name is 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde. A new synthetic method of this compound is introduced below., Computed Properties of C7H7NO2

2-((3S,4S)-4-(cyclopropylmethyl)pyrrolidin-3-yl)-7-(1,1-dioxothiomorpholino)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (129.98 mg)Dissolved in DCM (6 mL),Add 4-aldehyde-1-methylpyridine-2(1H)-one (54.6 mg, 0.398 mmol)Sodium triacetoxyborohydride (254.3 mg, 1.2 mmol) was stirred at room temperature overnight.TLC monitors the reaction completely,Add saturated aqueous sodium bicarbonate (5 mL),Extracted with DCM (3 x 10 mL),Combine the organic phase,Washed (2 × 5mL),Dry over anhydrous sodium sulfate,filter,concentrate,The crude product was subjected to silica gel column chromatography (DCM:MeOH=100:1-20:1)Purification of the white solid 2-((3S,4S)-4-(cyclopropylmethyl)-1-((1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-Pyrrolidin-3-yl)-7-(1,1-dioxothiomorpholinyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one(39.5 mg, yield: 23.2%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 94170-15-7, 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.94170-15-7, name is 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, molecular formula is C7H7NO2, molecular weight is 137.14, as common compound, the synthetic route is as follows.Application In Synthesis of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde

7-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)-2-((3S,4S)-4-isobutylpyrrolidin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (81.64 mg) was dissolved in DCM (4 mL).4-Aldehyde-1-methylpyridine-2(1H)-one (34.23 mg, 0.25 mmol) and sodium triacetoxyborohydride (110.2 mg, 0.52 mmol),Stir at room temperature overnight.TLC monitors the reaction completely,Add saturated aqueous sodium bicarbonate (5 mL),Extracted with DCM (3 x 10 mL),Organic phase merger,Washed (2 × 5mL),Dry over anhydrous sodium sulfate,filter,concentrate,The crude product was separated by preparative thin layer chromatography (DCM:MeOH = 10:1)A white solid 7-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)-2-((3S,4S)-4-isobutyl-1-((1-methyl-) 2-oxo-1,2-dihydropyridin-4-yl)methyl)pyrrolidin-3-yl)pyrrolo[2,1-f][1,2,4]triazine-4(3H)-ketone(4.0 mg, yield: 3.7%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,94170-15-7, 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 94170-15-7, 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, blongs to pyridine-derivatives compound. Quality Control of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde

Intermediate 1-10 (134.73 mg, 0.39 mmol) was dissolved in DCM (6 mL)4-Aldehyde-1-methylpyridine-2(1H)-one (64.2 mg, 0.468 mmol) and NaBH(OAc)3 (206.6 mg, 0.975 mmol),Stir at room temperatureThe reaction is complete,Add saturated aqueous sodium bicarbonate (5 mL),Extracted with DCM (3 x 10 mL),Combine the organic phase,Wash with water (2 × 5mL),Dry over anhydrous sodium sulfate,Filtered, concentrated,The crude product was purified by preparative HPLC to give a white solid(10.0 mg, yield: 5.5%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,94170-15-7, 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 94170-15-7 ,Some common heterocyclic compound, 94170-15-7, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

7-(1,1-Dioxythiomorpholinyl)-2-((3S,4S)-4-isobutylpyrrol-3-yl)pyrrolo[2,1-f][1,2,4-triazine-4(3H)-one (309.1 mg) was dissolved in DCM (6 mL).4-Aldehyde-1-methylpyridine-2(1H)-one (128.9 mg, 0.94 mmol) and sodium triacetoxyborohydride (416.5 mg, 1.965 mmol),Stir at room temperature overnight,TLC monitors the reaction completely,Add saturated aqueous sodium bicarbonate (5 mL),Extracted with DCM (3 x 10 mL),Organic phase merger,Washed (2 × 5mL),Dry over anhydrous sodium sulfate,filter,concentrate,The crude product was purified by silica gel column chromatography (DCM: MeOH=100:1-20:1)Yellow solid 7-(1,1-dioxythiomorpholinyl)-2-((3S,4S)-4-isobutyl-1-((1-methyl-2-oxo-1,2-di) Hydropyridin-4-yl)methyl)pyrrolidin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (80.0 mg, yield:19.8%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,94170-15-7, its application will become more common.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem