Category: 942189-65-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 942189-65-3, name is 2-(6-Bromopyridin-3-yl)pyrimidine. A new synthetic method of this compound is introduced below., Quality Control of 2-(6-Bromopyridin-3-yl)pyrimidine

A mixture of 2-(6-Bromo-pyridin-3-yl)-pyrimidine 76 (100mg, Q.425mmol), potassium carbonate (100mg,0.724mmol), and piperazine (100mg,1.16mmol) in DMF (5mi) were stirred at 1000C for 1 hour. The reaction was cooled.solvent evaporated under reduced pressure, and the residue dissolved in MeCb (150ml), washed with H2O (50ml),dried over MgSO4,filtered and evaporated solvent yielding title product 77 as a white solid (100mg,98%). ESMS (MH, 242).

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Reference:
Patent; SCHERING CORPORATION; WO2007/70398; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 942189-65-3 , The common heterocyclic compound, 942189-65-3, name is 2-(6-Bromopyridin-3-yl)pyrimidine, molecular formula is C9H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Refluxed mixture of 2-(6-Bromo-pyridin-3-yl)-pyrimidine (1Q) (200mg, 0.85mmol), N-tert-butoxycarbonyl-1 ,2,3,6-tetrahydropyridine-4-boronic acid, pinacol ester (290mg, 0.93mmol); Cesium Carbonate (500mg, 1.538mmol); PdCI2dppf (30mg) in dioxane/H2O (10ml v/v 4/1 ) for 4 hours. Cooled reaction, then evaporated solvent. Extracted with EtOAc (200ml) washed with H2O (50ml), dried over MgSO4, filtered and solvent evaporated yielding a solid which chromatographed on silica gel eluting with 30% v/v acetone/hexanes yielding 2Q as a white solid (110mg, 38%) ESMS (MH.339).

The synthetic route of 942189-65-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2008/156739; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 942189-65-3 , The common heterocyclic compound, 942189-65-3, name is 2-(6-Bromopyridin-3-yl)pyrimidine, molecular formula is C9H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Refluxed mixture of 2-(6-Bromo-pyridin-3-yl)-pyrimidine (1Q) (200mg, 0.85mmol), N-tert-butoxycarbonyl-1 ,2,3,6-tetrahydropyridine-4-boronic acid, pinacol ester (290mg, 0.93mmol); Cesium Carbonate (500mg, 1.538mmol); PdCI2dppf (30mg) in dioxane/H2O (10ml v/v 4/1 ) for 4 hours. Cooled reaction, then evaporated solvent. Extracted with EtOAc (200ml) washed with H2O (50ml), dried over MgSO4, filtered and solvent evaporated yielding a solid which chromatographed on silica gel eluting with 30% v/v acetone/hexanes yielding 2Q as a white solid (110mg, 38%) ESMS (MH.339).

The synthetic route of 942189-65-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2008/156739; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 942189-65-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 942189-65-3, name is 2-(6-Bromopyridin-3-yl)pyrimidine, molecular formula is C9H6BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-(6-Bromo-pyridin-3-yl)-pyrimidine 76 (100mg, 0.425mmol), potassium carbonate (100mg,0.724mmol), and piperazine (100mg,1.16mmol) in DMF’ (5ml), were stirred at 1000C for 1 hour. The reaction was cooled, solvent evaporated^/ – under reduced pressure, and the residue dissolved in MeCI2 (150ml), washed with H2O (50ml),dried over MgSO4,filtered and evaporated solvent yielding title product 77 as a white solid (100mg,98%). ESMS (MH, 242).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 942189-65-3, 2-(6-Bromopyridin-3-yl)pyrimidine.

Reference:
Patent; SCHERING CORPORATION; WO2008/156739; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 942189-65-3, 2-(6-Bromopyridin-3-yl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 942189-65-3, blongs to pyridine-derivatives compound. SDS of cas: 942189-65-3

Example 31 To a stirred solution of 10 (3.05g, 12.9 mmol) in DMF (30 mL) 1 (5.97 mL, 38.7 mmol) and DIPEA (8.5 mL, 51.7 mmol) was added. The clear mixture was heated at 80 C overnight before concentrated to a small volume and partitioned between ethyl acetate and brine. The separated organic layer was dried and concentrated to dryness. The resulting crude was purified on silica gel column (eluting with 15% to 30% ethyl acetate in hexanes) to yield 11 as a brown solid (4.5 g, 84%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,942189-65-3, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; ZHU, Hugh, Y.; DESAI, Jagdish, A.; COOPER, Alan, B.; DOLL, Ronald, J.; WO2011/41152; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem