Category: 94220-38-9

Application of 94220-38-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, molecular formula is C7H6ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 1 7-Allylamino-5-methyl-1H-pyrazolo[4,3-b]pyridine (E1) STR15 A mixture of 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) (1.0 g, 0.006 mole) and allylamine (60 g) in water (100 ml) was heated under reflux for 12 days. On cooling the reaction mixture was evaporated to dryness, basified to pH8 with 10% sodium carbonate solution and the resulting solid filtered off. Recrystallisation from chloroform/pentane gave the product as white solid (1.0 g). m.p. 172-174 C. delta(d6 DMSO): 2.40 (3H, s); 3.91 (2H, d, J=6.5 Hz); 3.4-5.0 (1H, br.s exchanges with D2 O); 5.00-5.50 (2H, m); 5.68-6.05 (1H, m); 6.15 (1H, s); 6.4-6.7 (1H, br.s exchanges with D2 O); 7.85 (1H, s). Found: C, 63.57; H, 6.35; N, 29.88. C10 H12 N4 requires C, 63.81; H, 6.43; N, 29.77%.

According to the analysis of related databases, 94220-38-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beecham Group p.l.c.; US4670432; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H6ClN3

EXAMPLE 10 7-(4-Dimethylaminoanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine. (E10) STR23 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (1 g), freshly prepared 4-dimethylaminoaniline (0.8 g), and absolute ethanol (20 ml) were heated under reflux in dry conditions in an atmosphere of nitrogen for 18 h. The solvent was removed in vacuo, the solid obtained was suspended in water, and the pH was adjusted to 7.8. The solid was filtered off, washed with water and dried to yield the 7-(4-dimethylaminoanilino)-compound (1.3 g, 80%) which on crystallisation from ethanol gave pale-yellow needles m.p. 215-218. (Found: C, 67.2; H, 6.4: N, 26.4. C15 H17 N5 requires C, 67.4; H, 6.4; N, 26.2%), numax. 3400-2500 (N–H), 1625, 1590, 1529, 1030, 942 cm-1, delta (CF3 COOH) 2.80 (3H, s, 5-CH3), 3.58 (6H, s, N(CH3)2), 7.00 (1H, s, 6-H), 7.89 (4H, s, aromatic protons), 8.52 (1H, s, 3-H), 9.70 (2H, s, N? H2), total proton count 17.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine.

Reference:
Patent; Beecham Group p.l.c.; US4576952; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6ClN3, blongs to pyridine-derivatives compound. Formula: C7H6ClN3

EXAMPLE 8 7-(2-Methylallylamino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (E8) STR22 The title compound was prepared from 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) and 2-methylallylamine as a pale yellow solid, m.p. 161-164, by the method given in Example 1. delta(DMSO-d6) 1.78 (3H,br s); 2.42 (3H,s); 3.87 (2H,br d, J-5 Hz); 4.8-5.1 (2H,m); 6.19 (1H,s); 6.57 (1H, br t); 7.93 (1H,s); 12.58 (1H,br s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Beecham Group p.l.c.; US4670432; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 94220-38-9 , The common heterocyclic compound, 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, molecular formula is C7H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 9 7-(3-Dimethylaminopropylamino)-5-methyl-1H-pyrazolo[4,3-b]pyridine hydrochloride, monohydrate (E9) STR23 A mixture of 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) (19.21 g, 0.115 mole) and 3-dimethylaminopropylamine (100 g) in xylene (770 ml) was heated at reflux under nitrogen for 83 h. After allowing to cool to room temperature, volatile material was removed under reduced pressure. The residue, an orange oil, was treated with ether and methanol and then left to stand at 4 C. overnight. The resulting pale yellow crystalline solid was collected, washed with ether/methanol and dried under vacuum to give the title compound (12.5 g, 38%), m.p. 183-186 C. (Found: C,50.29; H,7.53; N,24.44. C12 H19 N5.HCl.H2 O requires: C,50.08; H,7.69; N,24.34%). delta(DMSO-d6) 1.88-2.05 (2H,m); 2.47 (3H,s); 2.53 (6H,s); 2.82-2.95 (2H,m); 3.32-3.47 (2H,m); 6.37 (1H,s); 7.9 (1H, brs); 8.01 (1H, s);

The synthetic route of 94220-38-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beecham Group p.l.c.; US4670432; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 94220-38-9 , The common heterocyclic compound, 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, molecular formula is C7H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 9 7-(3-Dimethylaminopropylamino)-5-methyl-1H-pyrazolo[4,3-b]pyridine hydrochloride, monohydrate (E9) STR23 A mixture of 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) (19.21 g, 0.115 mole) and 3-dimethylaminopropylamine (100 g) in xylene (770 ml) was heated at reflux under nitrogen for 83 h. After allowing to cool to room temperature, volatile material was removed under reduced pressure. The residue, an orange oil, was treated with ether and methanol and then left to stand at 4 C. overnight. The resulting pale yellow crystalline solid was collected, washed with ether/methanol and dried under vacuum to give the title compound (12.5 g, 38%), m.p. 183-186 C. (Found: C,50.29; H,7.53; N,24.44. C12 H19 N5.HCl.H2 O requires: C,50.08; H,7.69; N,24.34%). delta(DMSO-d6) 1.88-2.05 (2H,m); 2.47 (3H,s); 2.53 (6H,s); 2.82-2.95 (2H,m); 3.32-3.47 (2H,m); 6.37 (1H,s); 7.9 (1H, brs); 8.01 (1H, s);

The synthetic route of 94220-38-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beecham Group p.l.c.; US4670432; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 94220-38-9 , The common heterocyclic compound, 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, molecular formula is C7H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 9 7-(3-Dimethylaminopropylamino)-5-methyl-1H-pyrazolo[4,3-b]pyridine hydrochloride, monohydrate (E9) STR23 A mixture of 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) (19.21 g, 0.115 mole) and 3-dimethylaminopropylamine (100 g) in xylene (770 ml) was heated at reflux under nitrogen for 83 h. After allowing to cool to room temperature, volatile material was removed under reduced pressure. The residue, an orange oil, was treated with ether and methanol and then left to stand at 4 C. overnight. The resulting pale yellow crystalline solid was collected, washed with ether/methanol and dried under vacuum to give the title compound (12.5 g, 38%), m.p. 183-186 C. (Found: C,50.29; H,7.53; N,24.44. C12 H19 N5.HCl.H2 O requires: C,50.08; H,7.69; N,24.34%). delta(DMSO-d6) 1.88-2.05 (2H,m); 2.47 (3H,s); 2.53 (6H,s); 2.82-2.95 (2H,m); 3.32-3.47 (2H,m); 6.37 (1H,s); 7.9 (1H, brs); 8.01 (1H, s);

The synthetic route of 94220-38-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beecham Group p.l.c.; US4670432; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 94220-38-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 1 7-(4-Cyanoanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (E1) STR14 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (4 g, 0.024 mole) was heated at reflux under nitrogen with 4-aminobenzonitrile (9.44 g, 0.08 mole) in dry xylene (25 ml) for 8 h. The resulting yellow crystalline solid was collected and washed repeatedly with ethyl acetate. This solid was recrystallized from methanol/ethyl acetate to give yellow needles (2.96 g, 43%) of the required product as its hydrochloride salt. A sample of this material (500 mg) was neutralised by dissolving with warming in the minimum volume of water/methanol and adding sufficient 10% sodium hydroxide to give a pH of 8. The resulting flocculant precipitate was collected, washed with water and dried to give a pale yellow solid (408 mg, 94%) which was recrystallized from ethyl acetate/methanol to give the title compound as the free base, m.p. 280-282 C. (decomposition). (Found: C, 66.13; H, 4.28; N, 27.81. C14 H11 N5.0.25H2 O requires C, 66.26; H, 4.57; N, 27.59%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine.

Reference:
Patent; Beecham Group p.l.c.; US4576952; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 94220-38-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 1 7-(4-Cyanoanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (E1) STR14 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (4 g, 0.024 mole) was heated at reflux under nitrogen with 4-aminobenzonitrile (9.44 g, 0.08 mole) in dry xylene (25 ml) for 8 h. The resulting yellow crystalline solid was collected and washed repeatedly with ethyl acetate. This solid was recrystallized from methanol/ethyl acetate to give yellow needles (2.96 g, 43%) of the required product as its hydrochloride salt. A sample of this material (500 mg) was neutralised by dissolving with warming in the minimum volume of water/methanol and adding sufficient 10% sodium hydroxide to give a pH of 8. The resulting flocculant precipitate was collected, washed with water and dried to give a pale yellow solid (408 mg, 94%) which was recrystallized from ethyl acetate/methanol to give the title compound as the free base, m.p. 280-282 C. (decomposition). (Found: C, 66.13; H, 4.28; N, 27.81. C14 H11 N5.0.25H2 O requires C, 66.26; H, 4.57; N, 27.59%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine.

Reference:
Patent; Beecham Group p.l.c.; US4576952; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 94220-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, molecular formula is C7H6ClN3, molecular weight is 167.5956, as common compound, the synthetic route is as follows.

EXAMPLE 6 7-[3-Dimethylaminopropylamino]-5-methyl-1H-pyrazolo[4,3-b]pyridine (E6) STR20 The title compound was prepared from 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) and 3-dimethylaminopropylamine by the method given in Example 2. On neutralization of the thus formed hydrochloride salt a clear solution was produced. After freeze drying, purification was carried out on Dowex 50W as described in Example 4, followed by crystallization from ethyl acetate to give the title compound as a white crystalline solid, m.p. 112-117. delta(DMSO-d6) 1.55-2.0 (2H,m), 2.23 (3H,s), 2.30-2.55 (2H,m), 3.1-3.5 (2H,m), 6.25 (1H,s), 6.72 (1H,br.t, J=4 Hz), 7.94 (1H,s).

The chemical industry reduces the impact on the environment during synthesis 94220-38-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Beecham Group p.l.c.; US4670432; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 94220-38-9

EXAMPLE 24 7-(3,4-Dichloroanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (24) STR37 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (1.5 g) and 3,4-dichloroaniline (1.45 g) were heated under reflux in ethanol (90 ml) for 48 h. The solvent was removed in vacuo to yield a yellow solid which was suspended in water and the pH adjusted to 7.8. The solid was filtered off, washed with water, and dried to yield the 7-(3,4-dichloroanilino)-compound (2.27 g, 87%) which was recrystallized from ethanol (charcoal) to yield a white amorphous solid m.p. 273 (dec.). (Found: C, 53.1; H, 3.5; N, 19.3; Cl, 24.1. C13 H10 N4 Cl2 requires C, 53.3; H, 3.45; N, 19.1; Cl, 24.2%), numax. 3400-2250 (N-H), 1630, 1580, 1530, 1410, 1400, 1310, 1135, 955, 850, 810 cm-1, delta (CF3 COOH) 2.76 (3H, s, 5-CH3), 6.86 (1H, s, 6-H), 7.49 (3H, m, aromatic protons), 8.46 (1H, s, 3-H), 9.47 (2H, s, N? H2), total proton count 10.

With the rapid development of chemical substances, we look forward to future research findings about 94220-38-9.

Reference:
Patent; Beecham Group, p.l.c.; US4559348; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem