Category: 94220-38-9

Reference of 94220-38-9, Adding some certain compound to certain chemical reactions, such as: 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine,molecular formula is C7H6ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 94220-38-9.

EXAMPLE 2 5-Methyl-7-piperidino-1H-pyrazolo(4,3-b)pyridine (2) STR15 7-Chloro-5-methyl-1H-pyrazolo(4,3-b)pyridine (1 g) and piperidine (10 ml) were heated under reflux for 24 h. The piperidine was removed in vacuo to yield a pale yellow solid which was washed with water to yield the piperidino-compound (1 g, 78%), Crystallisation from ethanol-water gave pale yellow crystals, m.p. 244. Found: C, 66.5; H, 7.55.; N, 25.7. C12 H16 N4 requires C, 66.6; H, 7.5; N, 25.9%), numax 2660-2200 (broad), 2000-1800 (broad), 1540, 1430, 1355, 1290, 1210, 1020, 980, 810 and 760 cm-1, delta (CF3 COOH) 1.97 (6H, s, –CH2 –), 2.70 (3H, s, 5 –CH3), 4.13 (4H, s, –N–CH2 –), 6.59 (1H, s, 6-H), 8.32 (1H, s, 3-H), total proton count 15.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Beecham Group, p.l.c.; US4559348; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H6ClN3, blongs to pyridine-derivatives compound. COA of Formula: C7H6ClN3

EXAMPLE 4 7-(4-Hydroxyanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (E4) STR17 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (0.5 g, 3 mmol) and 4-aminophenol (0.65 g, 6 mmol) in dry xylene (5 ml) were heated under reflux under nitrogen for 7 h. The resulting solid was collected and washed with water and ethyl acetate, then crystallized from methanol/ethyl acetate to give the hydrochloride salt of the required product (393 mg, 47%), m.p. 308-310 C. (dec.). The hydrochloride salt (355 mg, 1.28 mmol) was dissolved in water (20 ml) and methanol (10 ml) and the solution was adjusted to pH7 with 10% sodium carbonate, to give the title compound as yellow needles (283 mg, 92%), m.p. 174-176 C. (Found: C, 59.30; H, 5.36; N, 21.24. C13 H12 N4 O.1.25.H2 O requires C, 59.42 H, 5.56; N, 21.32).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Beecham Group p.l.c.; US4576952; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem