Category: 942947-94-6

Related Products of 942947-94-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 942947-94-6, name is 5-Bromo-4-chloropyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 5-bromo-4-chloropyridin-2-amine (2.0g, 9.64mmol, l .Oeq), Di-tert-butyl dicarbonate (5.25g, 24.1mmol, 2.5eq) and triethyl amine (2.423g, 24.1mmol, 2.5eq) in tetrahydrofuran (lOmL) was added. Then 4-Dimethylaminopyridine (0.117g, 0.964mmol, 0.1 eq) was added and the reaction mixture was stirred at room temperature for 18h. After completion of reaction, reaction mixture was concentrated under reduced pressure to obtain crude material. This was further purified by column chromatography and compound was eluted in 10% ethyl acetate in hexane as eluent to obtain 186.3. (2.10g, 53.43%). MS(ES): m/z 408.69 [M+H]+

According to the analysis of related databases, 942947-94-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (401 pag.)WO2018/71794; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 942947-94-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 942947-94-6, name is 5-Bromo-4-chloropyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 5-bromo-4-chloropyridin-2-amine (2.0g, 9.64mmol, l .Oeq), Di-tert-butyl dicarbonate (5.25g, 24.1mmol, 2.5eq) and triethyl amine (2.423g, 24.1mmol, 2.5eq) in tetrahydrofuran (lOmL) was added. Then 4-Dimethylaminopyridine (0.117g, 0.964mmol, 0.1 eq) was added and the reaction mixture was stirred at room temperature for 18h. After completion of reaction, reaction mixture was concentrated under reduced pressure to obtain crude material. This was further purified by column chromatography and compound was eluted in 10% ethyl acetate in hexane as eluent to obtain 186.3. (2.10g, 53.43%). MS(ES): m/z 408.69 [M+H]+

According to the analysis of related databases, 942947-94-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (401 pag.)WO2018/71794; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 942947-94-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.942947-94-6, name is 5-Bromo-4-chloropyridin-2-amine, molecular formula is C5H4BrClN2, molecular weight is 207.4557, as common compound, the synthetic route is as follows.

General procedure: To 30 mL 98% H2SO4 was added portionwise 4,5-dichloropyridin-2-amine (1.0 g, 6.13 mmol) at -5 C. After the solid material was completely dissolved, 3.7 mL fuming HNO3 was added dropwise over 5 min maintaining internal temperature ?0 C. The mixture was allowed to warm to 50 C over 2 h, and then stirred for another 1 h at this temperature before poured onto 150 g crushed ice. The aqueous solution was basified to pH = 7.3 with ammonia and extracted with ethyl acetate. The combined extracts were dried, concentrated and purified by column chromatography to give 4,5-dichloro-3-nitropyridin-2-amine (0.80 g, 62.6%). 5.2.2.31 7-Bromo-8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione (31) To a solution of 2-amino-4-chloropyridine (1.28 g, 10.0 mmol) in anhydrous CH3CN (40 mL) was added portionwise N-bromosuccinimide (1.96 g, 11.0 mmol). The reaction mixture was stirred at room temperature for 24 h then poured into 100 mL ice-water and extracted with ethyl acetate. The combined extracts were washed with 1 M NaOH and brine, dried and evaporated. The residue was purified by column chromatography on silica gel to give 5-bromo-4-dichloropyridin-2-amine (1.53 g, 60.8%). Next steps followed the procedure of 30 and gave the title compound as white solid (63 mg, 12.5% over 3 steps).

Statistics shows that 942947-94-6 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-4-chloropyridin-2-amine.

Reference:
Article; Xie, Dongsheng; Lu, Jun; Xie, Jin; Cui, Junjun; Li, Teng-Fei; Wang, Yan-Chao; Chen, Yuan; Gong, Nian; Li, Xin-Yan; Fu, Lei; Wang, Yong-Xiang; European Journal of Medicinal Chemistry; vol. 117; (2016); p. 19 – 32;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 942947-94-6, 5-Bromo-4-chloropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 942947-94-6, blongs to pyridine-derivatives compound. Computed Properties of C5H4BrClN2

Synthesis of 4-chloro-5-(4,4,5,5-tetramethyl(l,3,2-dioxaborolan-2-yl))-2- pyridylamine[00100] To a dry 500-mL flask was added 5-bromo-4-chloro 2-pyridylamine (7.3 g, 35.8 mmol), potassium acetate (10.3 g, 105 mmol), 4,4,5,5-tetramethyl-2-(4,4,5,5- tetramethyl-l ,3,2-dioxaborolan-2-yl)-l,3,2-dioxaborolane (10.1 g, 39.8 mmol) and dioxane (150 mL). Argon was bubbled through the solution for 15 minutes, at which time l,l’-bis(diphenylphosphino)ferrocene palladium(II) chloride dichloromethane adduct (0.85 g, 1.04 mmol) was added. The reaction was refluxed in a 1 15 C oil bath for 6 hours under argon. After cooling to room temperature, the dioxane was removed in vacuo. EtOAc (500 mL) was then added and the resulting slurry was sonicated and filtered. Additional EtOAc (500 mL) was used to wash the solid. The combined organic extracts were concentrated and the crude material was purified by Si02 chromatography (EtOAc as eluent). Upon removal of solvent, 3: 1 hexanes/CH2Cl2 was added (100 mL). After soni cation, the resulting solid was filtered and concentrated in vacuo yielding 2.8 g of a white solid. By ¾ NMR the material was a 10: 1 mixture of boronate ester and 2-amino-4-chloropyridine byproduct. The material was used as is in subsequent Suzuki reactions. LCMS (m/z):173 (MH+ of boronic acid, deriving from in situ product hydrolysis on LC). ¾ NMR (CDCI3): delta 8.36 (s, 1H), 6.46 (s, 1H), 4.70 (bs, 2H), 1.38 (s, 12H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,942947-94-6, its application will become more common.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; ZHAO, Jean J.; WANG, Qi; WO2012/109423; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.942947-94-6, name is 5-Bromo-4-chloropyridin-2-amine, molecular formula is C5H4BrClN2, molecular weight is 207.4557, as common compound, the synthetic route is as follows.Product Details of 942947-94-6

To a 1 L 3 necked round-bottomed flask equipped with a magnetic stirrer, heating mantle, and N2 inlet was added 5-bromo-4-chloropyridin-2 -amine (25 g, 121 mmol) and sodium hydrogen sulfide hydrate (26.5 g, 362 mmol). The flask was evacuated and purged with N2 three times. To the solids, N2 sparged l-methyl-2-pyrrolidinone (250 mL) was added. The green suspension was heated to 70 C for 17 hours. The suspension was cooled to room temperature. A cooled bleach scrubber containing 750 mL of bleach was installed and to the suspension concentrated HCl (24.90 mL, 301 mmol) was added. Gas evolution was noted. The resulting dark brown/red suspension was sparged with N2 for 30 minutes. The solids were removed under N2 filtration and were washed with N2 sparged ethanol (100 mL) to give a solution of 2-amino-5-bromopyridine-4-thiol (350 mL) which was used directly in the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,942947-94-6, 5-Bromo-4-chloropyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; ABBVIE INC.; KALLEMEYN, Jeff M.; KU, Yi-Yin; MULHERN, Mathew M.; WO2015/157360; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 942947-94-6 ,Some common heterocyclic compound, 942947-94-6, molecular formula is C5H4BrClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Production Example 23-1 tert-Butyl N-(5-bromo-4-chloropyridin-2-yl)-N-[(tert-butoxy)carbonyl]carbamate To a solution of 5-bromo-4-chloropyridin-2-amine (3.0 g, 14 mmol), di-tert-butyl dicarbonate (9.5 g, 43 mmol), and triethylamine (6.1 mL, 43 mmol) in tetrahydrofuran (100 mL), 4-dimethylaminopyridine (0.18 g, 1.5 mmol) was added, and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and then the residue was separated and purified by silica gel column chromatography (ethyl acetate:heptane) to obtain the title compound (3.2 g, 55% yield). 1H-NMR Spectrum (400 MHz, CDCl3) delta (ppm): 1.48 (s, 18H), 7.47 (s, 1H), 8.58 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 942947-94-6, 5-Bromo-4-chloropyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eisai R&D Management Co., Lt.d; Tanaka, Keigo; Fukuyama, Takashi; Murai, Norio; Itano, Wataru; Hirota, Shinsuke; Iida, Daisuke; Azuma, Hiroshi; (32 pag.)US2016/168176; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 942947-94-6, 5-Bromo-4-chloropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H4BrClN2, blongs to pyridine-derivatives compound. Computed Properties of C5H4BrClN2

A mixture of water (2.2 mL) and concentrated sulfuric acid (0.31 mL, 5.78 mmol) was cooled to 0 C and 5-bromo-4-chloropyridin-2-amine (500 mg, 2.41 mmol) was added in one portion. A solution of sodium nitrite (183 mg, 2.65 mmol) in water (0.2 mL) was added dropwise so that the internal temperature did not rise above 5 C. The reaction was stirred at 0 C for 3 h. The suspension was taken to pH 7 by addition of (0687) concentrated aqueous ammonia and the precipitate was collected by filtration to give the title compound (440 mg, 88%) as a pale yellow solid. LCMS (Method B): RT = 0.70 min, m/z = 209 [M+H]+. 1 H NMR (400 MHz, DMSO-d6): delta 7.94 (s, 1 H), 6.75 (s, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,942947-94-6, 5-Bromo-4-chloropyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; ALMAC DISCOVERY LIMITED; HEWITT, Peter; MCFARLAND, Mary Melissa; ROUNTREE, James Samuel Shane; BURKAMP, Frank; BELL, Christina; PROCTOR, Lauren; HELM, Matthew Duncan; O’DOWD, Colin; HARRISON, Timothy; (280 pag.)WO2018/20242; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem