Category: 94413-70-4

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.94413-70-4, name is 4-(Aminomethyl)-2-methylpyridine, molecular formula is C7H10N2, molecular weight is 122.1677, as common compound, the synthetic route is as follows.Safety of 4-(Aminomethyl)-2-methylpyridine

To a stirred solution of 3-(3,4-dimethoxyphenyl)-8-iodo-2,6-dimethylimidazo[l,2-b]pyridazine (0.1 g, 0.240 mmol) and (2-methylpyridin-4-yl)methanamine (0.06 g, 0.312 mmol) in toluene (2 mL) was added cesium carbonate (0.156 g, 0.48 mmol), 2,2′-bis(diphenylphosphino)-l ,l ‘- binaphthyl (BINAP (7 mg, 0.012 mmol) and Pd(OAc)2 (2 mg, 0.012 mmol). The reaction was stirred at l05C for l6h. Upon completion, the reaction was diluted with 10% MeOH-CH2Cl2 and filtered through a celite bed. The filtrate was concentrated and the obtained solid was washed with acetonitrile to afford 3-(3,4-dimethoxyphenyl)-2,6-dimethyl-N-((2-methylpyridin-4- yl)methyl)imidazo[l,2-b]pyridazin-8-amine (0.09 g, 91.83%) as a pale brown solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,94413-70-4, 4-(Aminomethyl)-2-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; CUROVIR AB; WESTMAN, Jacob; (78 pag.)WO2020/74160; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 94413-70-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 94413-70-4, name is 4-(Aminomethyl)-2-methylpyridine. A new synthetic method of this compound is introduced below.

EXAMPLE 10 Reduction of 4-Cyano-2-methylpyridine The first-described method of Example 6 was used with isolation by distillation. The spectroscopic properties of the product were consistent with 2-methyl-4-pyridinemethanamine (81% yield): nmr (D2O, ppm) 3.55 (S,3), 3.96 (S,2), 4.61 (S,2), 7.0-8.1 (m,3); ir (nujol mull, cmmin1) 3000-3300, 1515, 1475.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,94413-70-4, 4-(Aminomethyl)-2-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; REILLY INDUSTRIES, INC.; EP161737; (1991); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem