Category: 944317-27-5

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 944317-27-5, name is 6-Bromo-3-chloro-2-methylpyridine, the common compound, a new synthetic route is introduced below. Quality Control of 6-Bromo-3-chloro-2-methylpyridine

: 2-(tributylstannyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole (2.69 g, 6.78 mmol), 6-bromo-3-chloro-2-methyl-pyridine (700.00 mg, 3.39 mmol), lithium chloride (287.43 mg, 6.78 mmol) and tetrakis(triphenylphosphine)palladium (391.77 mg, 339.00 mumol) were added to dioxane (30 mL). The reaction mixture was charged with nitrogen three times, then heated to 100-110 C and stirred for 12 h. The mixture was quenched by pouring into water (50 mL) and extracted with ethyl acetate (50 mL*3). The combined organic phases were washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatograph (eluent: petroleum ether/ethyl acetate=10/1-5/1) to give 2-(5-chloro-6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b] pyrazole (600.00 mg, yield: 67.19%). 1H NMR (400MHz, CHLOROFORM-d) 7.65(q, J = 8.4 Hz, 2H), 6.59(s, 1H), 4.22(t, J = 7.2 Hz, 2H), 2.95(t, J = 7.3 Hz, 2H), 2.71-2.59(m, 5H).

The synthetic route of 944317-27-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Genfleet Therapeutics (Shanghai) Inc.; Medshine Discovery Inc.; SUN, Fei; WU, Lifang; DING, Charles Z.; HU, Guoping; LI, Jian; CHEN, Shuhui; LU, Jianyu; (45 pag.)EP3470409; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 944317-27-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 944317-27-5, name is 6-Bromo-3-chloro-2-methylpyridine. A new synthetic method of this compound is introduced below.

6-Bromo-3-chloro-2-methylpyridine (1.07 g), Pd(dppf)Cl2 DCM (423 mg) and triethylamine (524 mg) were stirred in a mixed solution of methanol (7.5 mL) and DMF (7.5 mL) in the presence of carbon monoxide (3 atm) at 90C for 3 hr. The solvent of the reaction mixture was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (724 mg). MS (ESI+) : [M+H]+185.9.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,944317-27-5, 6-Bromo-3-chloro-2-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Pharmaceutical Company Limited; OGINO, Masaki; KIMURA, Eiji; SUZUKI, Shinkichi; ASHIZAWA, Tomoko; IMAEDA, Toshihiro; FUJIMORI, Ikuo; ARAI, Ryosuke; (82 pag.)EP3156397; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 944317-27-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 944317-27-5, name is 6-Bromo-3-chloro-2-methylpyridine. A new synthetic method of this compound is introduced below.

6-Bromo-3-chloro-2-methylpyridine (1.07 g), Pd(dppf)Cl2 DCM (423 mg) and triethylamine (524 mg) were stirred in a mixed solution of methanol (7.5 mL) and DMF (7.5 mL) in the presence of carbon monoxide (3 atm) at 90C for 3 hr. The solvent of the reaction mixture was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (724 mg). MS (ESI+) : [M+H]+185.9.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,944317-27-5, 6-Bromo-3-chloro-2-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Pharmaceutical Company Limited; OGINO, Masaki; KIMURA, Eiji; SUZUKI, Shinkichi; ASHIZAWA, Tomoko; IMAEDA, Toshihiro; FUJIMORI, Ikuo; ARAI, Ryosuke; (82 pag.)EP3156397; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem