Category: 944401-65-4

Application of 944401-65-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.944401-65-4, name is 5-Bromo-6-fluoropyridin-2-amine, molecular formula is C5H4BrFN2, molecular weight is 191, as common compound, the synthetic route is as follows.

Synthesis of 5-cyclopropyl-6-fluoropyridin-2-amine. A solution of 5-bromo-6-fluoropyridin-2-amine (3.0 g, 15.8 mmol), cyclopropylboronic acid (2.04 mg, 23.7 mmol), Pd(OAc)2 (354 mg, 1.58 mmol), PCy3 (886.2 mg, 3.16 mmol) and K3PO4(6.7 g, 31.6 mmol) in dioxane/H2O (30 mL/3 mL) was stirred at 100 C. for 16 h. Then the reaction mixture was diluted with H2O (50 mL) and extracted with EtOAc (100 mL*3). The combined organic layers were dried over Na2SO4 and concentrated to give the desired compound 5-cyclopropyl-6-fluoropyridin-2-amine (yellow oil, 2.2 g). ESI-MS [M+H]+: 153.2.

Statistics shows that 944401-65-4 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-6-fluoropyridin-2-amine.

Reference:
Patent; Shire Human Genetic Therapies, Inc.; Papaioannou, Nikolaos; Fink, Sarah Jocelyn; Miller, Thomas Allen; Shipps, JR., Gerald Wayne; Travins, Jeremy Mark; Ehmann, David Edward; Rae, Alastair; Ellard, John Mark; (352 pag.)US2019/284182; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 944401-65-4, Adding some certain compound to certain chemical reactions, such as: 944401-65-4, name is 5-Bromo-6-fluoropyridin-2-amine,molecular formula is C5H4BrFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 944401-65-4.

A solution of sodium nitrite (21.67g, 314.13mmol) in water (150mL) was added dropwise to a stirred mixture of 5-bromo-6-fluoropyridin-2-amine (50g, 261.78mmol) and sulphuric acid (1.2mL, 22.51mmol) in water (750mL) at 0-5C. The resulting suspension was stirred for 48 h at ambient temperature then the precipitate collected by filtration, washed with water (200mL) and dried under vacuum to afford the desired material (40. Og, 80%) as a pale yellow solid, which was used without further purification. NMR Spectrum: 1H NMR (300MHz, DMSO-d6) delta 6.55 (1H, d), 8.00 (1H, t), 11.71 (1H, bs). Mass Spectrum: m/z (ES+)[M+H]+ = 192.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 944401-65-4, 5-Bromo-6-fluoropyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BARLAAM, Bernard Christophe; PIKE, Kurt Gordon; WO2015/170081; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem