Application of 944445-41-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 944445-41-4, name is 3-(Benzyloxy)-2-(chloromethyl)pyridine, molecular formula is C13H12ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Stage B: 3-(Benzyloxy)-2-(methoxymethyl)pyridine The solution of 41 g (0.18 mol) of 3-(benzyloxy)-2-(chloromethyl)pyridine in 100 ml of methanol is added to the solution of sodium methoxide, prepared by adding 5.2 g (0.23 mol) of sodium to 150 ml of methanol. After refluxing for 3 hours under nitrogen, the solution is concentrated to dryness. The oil obtained is taken up in water and extracted with ethyl acetate. The organic solution is washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulphate, and then concentrated to dryness. 39 g (97%) of a brown oil are obtained. 1H-NMR [(CD3)2SO, 250 MHz]: 8.15 (1H, d), 7.30-07.55 (7H, m), 5.22 (2H, s), 4.55 (2H, s), 3.31 (3H, s).
According to the analysis of related databases, 944445-41-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANOFI-AVENTIS; US2009/69368; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem