Category: 945717-09-9

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 945717-09-9, name is 2-Chloro-4-ethynylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Chloro-4-ethynylpyridine

To a solution of the compound i18 (1g, 1.95mmol) in DMF (10mL) was added Et3 N (0.812mL, 5.86mmol), 2-chloro-4-ethynylpyridine (806mg, 5.86mmol), copper iodide (37.2mg, 0.195mmol), and PdCl2 (PPh3)2(137mg,0.195mmol), the mixture was stirred under nitrogen atomosphere at 100 C for 1 hour. Water was added to the reactionsolution, extracted with ethyl acetate, and the organic layer was washed water, dried over anhydrous sodium sulfate,concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane – ethylacetate) to yield the compound 23 (574mg, yield 56%). LC/MS (ESI):m/z = 522.20 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 945717-09-9.

Reference:
Patent; Shionogi & Co., Ltd.; KAWASUJI, Takashi; TANIYAMA, Daisuke; SUGIYAMA, Shuichi; TAMURA, Yoshinori; (153 pag.)EP3144311; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 945717-09-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 945717-09-9 as follows.

To a solution of 22700mg, 0.306mmol) and 7(63.7mg, 0.6ilmmol) in 2OmL of Et3N was added Pd(PPh3)2C12 (10.73 rng, 0.Ol5mmoI) and CuT (5.82mg, 0.O3lmmol). The mixture was protected with N2 atmosphere, then was heated at 70C for 24 hours. TLC analysis showedcomplete conversion of starting material to a major product. The reaction mixture was then concentrated in vacua The crude product was purified by Prep-HPLC to give the target product Compound 100(19mg, yield: 18.46%).LCMS: m/z 337 (M+H)?1H NMR (400 MFIz, CDCI3): oe 8.40-8.39 (in, 1 El), 7.66 (s, IH), 7.59-7.56 (m, 11-1), 7.47 (s, 1 El),7.44-7.41 (m, 1H), 7.34-7.33 (in, 1H), 6.50 (s, 1H), 2.47 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,945717-09-9, its application will become more common.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem