Category: 945954-94-9

Related Products of 945954-94-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.945954-94-9, name is Methyl 6-bromo-3-methoxypicolinate, molecular formula is C8H8BrNO3, molecular weight is 246.06, as common compound, the synthetic route is as follows.

44 mmol of sodium borohydride are added in portions to a solution of 2.2 mmol of methyl 6- bromo-3-methoxypyridine-2-carboxylate in 750 ml of methanol. The mixture is stirred at room temperature for 2 days. Water is added to the reaction mixture, and it is extracted with dichloromethane (3x). The combined organic phases are dried with sodium sulphate and concentrated. The solid resulting after addition of n-hexane is filtered off with suction and dried.

The chemical industry reduces the impact on the environment during synthesis 945954-94-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SPEEDEL EXPERIMENTA AG; WO2007/31558; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.945954-94-9, name is Methyl 6-bromo-3-methoxypicolinate, molecular formula is C8H8BrNO3, molecular weight is 246.06, as common compound, the synthetic route is as follows.HPLC of Formula: C8H8BrNO3

(step .4); To a solution of the compound obtained in step 3 (7.56 g) in THF (110 mL) was added diisobutylaluminum hydride (DIBAL-H) ( 1.5M toluene solution, 24.6 mL) at -78C, and the mixture was stirred at -78C for 1 hr. To the reaction mixture was added saturated aqueous Rochelle salt, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel column chromatography (solvent gradient; 0->33% ethyl acetate/hexane) and crystallized from ethyl acetate/hexane to give 6-bromo-3-methoxypyridine-2- carbaldehyde (5.36 g, 81%) as white crystals,

At the same time, in my other blogs, there are other synthetic methods of this type of compound,945954-94-9, Methyl 6-bromo-3-methoxypicolinate, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/89031; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 945954-94-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 945954-94-9, name is Methyl 6-bromo-3-methoxypicolinate. This compound has unique chemical properties. The synthetic route is as follows.

A solution of methyl 6-bromo-3 -methoxypicolinate (3.0 g, 12.19 mmol) and LiOH-H20 (1.4 g, 33.36 mmol) in 1,4-dioxane / H20 (15 mL / 15 mL) was stirred at RT overnight. The mixture was filtered and the filtrate was adjusted to pH = 3 by aqueous HC1 (2 M) and extracted with EtOAc. The combined organic phase was washed with brine, dried over Na2S04 and concentrated to give the crude product of 6-bromo-3-methoxypicolinic acid (2.1 g, yield: 73 %) without further purification. XH-NMR (CDC13, 400 MHz) delta 10.05 (br s, 1H), 7.70 (d, J = 8.8 Hz, 1H), 7.40 (d, J = 8.8 Hz, 1H), 4.01 (s, 3H). MS (M+H)+: 232 / 234.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 945954-94-9, Methyl 6-bromo-3-methoxypicolinate.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 945954-94-9, name is Methyl 6-bromo-3-methoxypicolinate. A new synthetic method of this compound is introduced below., Safety of Methyl 6-bromo-3-methoxypicolinate

A mixture of methyl 6-bromo-3-methoxypicolinate (4 g, 18.4 mmol) and LiOH- H20 (1.6 g, 36.9 mmol) in dioxane / H20 (5 / 1, 40 mL) was stirred at RT overnight. After pH was adjusted to 7, the mixture was filtered to provide crude 6-bromo-3-methoxypicolinic acid (3.1 g, yield: 81 %). 1H- MR (CDC13 , 400 MHz) delta 10.71 (m, 1H), 7.70 (d, J= 8.0 Hz, 1H), 7.40 (d, J= 8.0 Hz, 1H), 4.01 (s, 3H). MS (M+H)+: 232 / 234.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 945954-94-9, Methyl 6-bromo-3-methoxypicolinate.

Reference:
Patent; MERCK SHARP & DOHME CORP.; HE, Shuwen; DAI, Xing; PALANI, Anandan; NARGUND, Ravi; LAI, Zhong; ZORN, Nicolas; XIAO, Dong; DANG, Qun; LI, Peng; PENG, Xuanjia; SOLL, Richard; WO2014/121418; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 945954-94-9, name is Methyl 6-bromo-3-methoxypicolinate. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 945954-94-9

A solution of methyl 6-bromo-3-methoxypicolinate (3.0 g, 12.19 mmol) andLiOHH2O (1.4 g, 33.36 mmol) in 1,4-dioxane / H20 (15 mL / 15 mL) was stirred at RT overnight. The mixture was filtered and the filtrate was adjusted to pH = 3 by aqueous HC1 (2 M) and extracted with EtOAc. The combined organic phase was washed with brine, dried over Na2504 andconcentrated to give the crude product of 6-bromo-3-methoxypicolinic acid (2.1 g, yield: 73 %)without further purification. ?H-NMR (CDC13, 400 MHz) 10.05 (br s, 1H), 7.70 (d, J = 8.8 Hz,1H), 7.40 (d, J = 8.8 Hz, 1H), 4.01 (s, 3H). MS (M+H): 232 / 234.

With the rapid development of chemical substances, we look forward to future research findings about 945954-94-9.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/205593; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem