Category: 947249-13-0

Related Products of 947249-13-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 947249-13-0, name is 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, molecular formula is C6H5BrF2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 4:84To a solution of compound 83 ( 5.61 g, 23.5 mmol) in acetonitrile (250 mL) was added di-terf- butyl-dicarbonate (15.65 g, 71.71 mmol), 4-(dimethylamino)pyridine (571 mg, 4.67 mmol), and triethyl amine (16.5 mL, 118 mmol). The mixture was stirred at room temperature for 1.5 hours, then concentrated to dryness and purified by silica gel chromatography (eluting with 10-25% ethyl acetate in hexanes gradient) to give compound 84 (9.53 g, 92.4%) as a white solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine.

Reference:
Patent; PFIZER INC.; WO2009/16460; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, blongs to pyridine-derivatives compound. Quality Control of 5-Bromo-3-(difluoromethoxy)pyridin-2-amine

To a mixture of 5-bromo-3-(difluoromethoxy)pyridin-2-amine (1.00 g, 4.18 mmol) in EtOH (10.0 mL) was added 2-bromo-l, l-di ethoxy ethane (1.07 g, 5.44 mmol, 818 uL) and HBr (7.45 g, 30.4 mmol, 5.00 mL, 33% in HOAc), and the mixture was stirred at 90 C for 16 h. The mixture was concentrated under reduced pressure to remove EtOH, and the residue was dissolved into ethyl acetate (50.0 mL) and washed with NaHC03 (50 mL) and brine (50.0 mL). The organic layer was dried with Na2S04, then concentrated under reduced pressure to give 6-bromo-8-(difluorom ethoxy )imidazo[l,2-a]pyri dine (900 mg, 3.42 mmol, 82% yield) as a brown solid. LC-MS (ESI+) m/z 265.1 (M+H)+; 1HNMR (400 MHz, MeOD): d 8.67 (s, 1 H), 7.98 (d, 1 H), 7.67 (s, 1 H), 7.29 (s, 1 H), 7.46 – 7.10 (m, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; TAYLOR, Alexander, M.; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; WALTERS, W., Patrick; MURCKO, Mark, Andrew; MCLEAN, Thomas, H.; GUNAYDIN, Hakan; GIORDANETTO, Fabrizio; THERRIEN, Eric; (607 pag.)WO2019/183367; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 947249-13-0, Adding some certain compound to certain chemical reactions, such as: 947249-13-0, name is 5-Bromo-3-(difluoromethoxy)pyridin-2-amine,molecular formula is C6H5BrF2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 947249-13-0.

A glass reaction vessel (bomb) was charged with a mixture of 5-bromo-3- (difluoromethoxy)pyridin-2-amme(8, 6.212 g, 26,0 mmol), Bis(pinacolato)diboron (6.93 g, 27.3 mmol), Pd2(dba)3(0.952 g, 1.040 mraol), tricyclohexylphosph»ne(l .020 g, 3.64 mmol), and KOAc(5.36 g, 56.4 mmol) in anhydrous dioxane(70 ml). The mixture was carefully sparged with argon, the reaction vessel sealed, and heated to about 1 1OC in an oil bath for 24 hours. LCMS of aliquot indicated complete conversion of 8 to product I4H ([M+H]« 205.0 as acid, /R – 0.27min), Reaction mixture was diluted with EtOAc(70ml) aftere it cooled down to ambient temperature, filtered through neutral alumina(~30ml, 2.5ml thickness), alumina cake was washed throughly with IUtOAc(IOOmI), and filtrate was combined, concentrated and a light brown solid residue was obtained. The brown residue was triturated in heptane( 100ml) at (PC, desired product precipitated out, was collected via filtration and filter cake was rinsed throughly with heptane, final product 14H was obtained as a yellow solid(7.777g, 74% yield, }M+H]:…205.0, /kappa = 0.27min) after dried under high vacuum. ‘ H NMR confirmed structure, and an unidentified impurity at ~1.3ppm was found by 1H NMR. This impurity peak was probable a pinacole t-Bu group, and -1 : 1 tnol ratio to product. 1H NMR (400 MHz, CDCl,) delta ppm 8,27 (d, ./ « 1.5 Hz, 1 H), 7.55 (a, 1 H), 6.51 (t, JF-H= 73.6 Hz, 1H), 1.27 (8, 12 VI).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; HUANG, Zilin; SENDZIK, Martin; WO2010/100127; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A mixture of 5-bromo-3-(difluoromethoxy)pyridine-2-amine (88mg, 0.37 mmol), bis(pinacolato)diboron (102mg, 0.40 mmol), potassium acetate (0.215mg, 2.2 mmol), and Pd(dppf)-CH2C12 (30mg, 0.037mmol) in dry dioxane (2.0 mL) was sparged with argon, and heated at 12O0C for 30 min. After cooling to rt, the reaction mixture was centrifuged and the supernatant decanted, and used in the next step without further purification: LCMS (m/z, MH+, boronic acid): 205.0, R = 0.27min.

The synthetic route of 947249-13-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; WO2009/115572; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 947249-13-0, Adding some certain compound to certain chemical reactions, such as: 947249-13-0, name is 5-Bromo-3-(difluoromethoxy)pyridin-2-amine,molecular formula is C6H5BrF2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 947249-13-0.

A glass reaction vessel (bomb) was charged with a mixture of 5-bromo-3- (difluoromethoxy)pyridin-2-amme(8, 6.212 g, 26,0 mmol), Bis(pinacolato)diboron (6.93 g, 27.3 mmol), Pd2(dba)3(0.952 g, 1.040 mraol), tricyclohexylphosph»ne(l .020 g, 3.64 mmol), and KOAc(5.36 g, 56.4 mmol) in anhydrous dioxane(70 ml). The mixture was carefully sparged with argon, the reaction vessel sealed, and heated to about 1 1OC in an oil bath for 24 hours. LCMS of aliquot indicated complete conversion of 8 to product I4H ([M+H]« 205.0 as acid, /R – 0.27min), Reaction mixture was diluted with EtOAc(70ml) aftere it cooled down to ambient temperature, filtered through neutral alumina(~30ml, 2.5ml thickness), alumina cake was washed throughly with IUtOAc(IOOmI), and filtrate was combined, concentrated and a light brown solid residue was obtained. The brown residue was triturated in heptane( 100ml) at (PC, desired product precipitated out, was collected via filtration and filter cake was rinsed throughly with heptane, final product 14H was obtained as a yellow solid(7.777g, 74% yield, }M+H]:…205.0, /kappa = 0.27min) after dried under high vacuum. ‘ H NMR confirmed structure, and an unidentified impurity at ~1.3ppm was found by 1H NMR. This impurity peak was probable a pinacole t-Bu group, and -1 : 1 tnol ratio to product. 1H NMR (400 MHz, CDCl,) delta ppm 8,27 (d, ./ « 1.5 Hz, 1 H), 7.55 (a, 1 H), 6.51 (t, JF-H= 73.6 Hz, 1H), 1.27 (8, 12 VI).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; HUANG, Zilin; SENDZIK, Martin; WO2010/100127; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A mixture of 5-bromo-3-(difluoromethoxy)pyridine-2-amine (88mg, 0.37 mmol), bis(pinacolato)diboron (102mg, 0.40 mmol), potassium acetate (0.215mg, 2.2 mmol), and Pd(dppf)-CH2C12 (30mg, 0.037mmol) in dry dioxane (2.0 mL) was sparged with argon, and heated at 12O0C for 30 min. After cooling to rt, the reaction mixture was centrifuged and the supernatant decanted, and used in the next step without further purification: LCMS (m/z, MH+, boronic acid): 205.0, R = 0.27min.

The synthetic route of 947249-13-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; WO2009/115572; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 947249-13-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.947249-13-0, name is 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, molecular formula is C6H5BrF2N2O, molecular weight is 239.02, as common compound, the synthetic route is as follows.

A mixture of 5-bromo-3-(difluoromethoxy)pyridine-2-amine (88 mg, 0.37 mmol), bis(pinacolato)diboron (102 mg, 0.40 mmol), potassium acetate (0.215 mg, 2.2 mmol), and Pd(dppf)-CH2Cl2 (30 mg, 0.037 mmol) in dry dioxane (2.0 mL) was sparged with argon, and heated at 120 C. for 30 min. After cooling to rt, the reaction mixture was centrifuged and the supernatant decanted, and used in the next step without further purification: LCMS (m/z, MH+, boronic acid): 205.0, tR=0.27 min.

Statistics shows that 947249-13-0 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-3-(difluoromethoxy)pyridin-2-amine.

Reference:
Patent; Huang, Zilin; Jin, Jeff; Machajewski, Timothy; Antonios-McCrea, William R.; McKenna, Maureen; Poon, Daniel; Renhowe, Paul A.; Sendzik, Martin; Shafer, Cynthia; Smith, Aaron; Xu, Yongjin; Zhang, Qiong; Chen, Zheng; US2013/210818; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 947249-13-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 947249-13-0, name is 5-Bromo-3-(difluoromethoxy)pyridin-2-amine. A new synthetic method of this compound is introduced below.

To a solution of 5-bromo-3-(difluoromethoxy)pyridin-2-amine (3.2 g, 13.39 mmol) in 1 ,4-dioxane (60 mL) were added4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi( 1 ,3,2-dioxaborolane) (3.74 g, 14.73 mmol),tricyclohexylphosphine (525 mg, 1.87 mmol), potassium acetate (3.28 g, 33.47 mmol) and tris(dibenzylideneacetone)dipalladium(0) (490 mg, 0.53 mmol). The reaction mixture was purged with nitrogen for 2 mm and heated to 110 C for 16 h and subsequently concentrated to dryness in vacuo. The resulting viscous mass was diluted with water and extracted with ethyl acetate (3 x 75 mL). The combined organic layers were dried over sodium sulfate andconcentrated to dryness in vacuo. The resulting residue was purified by column chromatography (silica gel, 100-200 mesh, 25% ethyl acetate in hexane) affording 3-(difluoromethoxy)-5- (4,4,5 ,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)pyridin-2-amine (1.3 g, 34%): 1H NMR (400 MHz, DMSO-d6) oe: 8.03 (s, 1H), 7.33 (s, 1H), 7.11 (t, I = 73.6 Hz, 1H),6.44 (s, 2H), 1.25 (s, 12H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; LYSSIKATOS, Joseph P.; LIU, Wen; SIU, Michael; ESTRADA, Anthony; PATEL, Snahel; LIANG, Guibai; HUESTIS, Malcolm; CHEN, Kevin; WO2015/91889; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 947249-13-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 947249-13-0, name is 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, molecular formula is C6H5BrF2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 5-bromo-3-(difluoromethoxy)pyridin-2-amine (3.2 g, 13.39 mmol) in 1,4-dioxane (60 mL) were added 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (3.74 g, 14.73 mmol), tricyclohexylphosphine (525 mg, 1.87 mmol), potassium acetate (3.28 g, 33.47 mmol) and tris(dibenzylideneacetone)dipalladium(0) (490 mg, 0.53 mmol). The reaction mixture was purged with nitrogen for 2 min and heated to 110 C. for 16 h and subsequently concentrated to dryness in vacuo. The resulting viscous mass was diluted with water and extracted with ethyl acetate (3*75 mL). The combined organic layers were dried over sodium sulfate and concentrated to dryness in vacuo. The resulting residue was purified by column chromatography (silica gel, 100-200 mesh, 25% ethyl acetate in hexane) affording 3-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (1.3 g, 34%): 1H NMR (400 MHz, DMSO-d6) delta 8.03 (s, 1H), 7.33 (s, 1H), 7.11 (t, J=73.6 Hz, 1H), 6.44 (s, 2H), 1.25 (s, 12H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine.

Reference:
Patent; GENENTECH, INC.; Siu, Michael; Estrada, Anthony; Liu, Wen; Lyssikatos, Joseph P.; Patel, Snahel; Liang, Guibai; Chen, Kevin; US2015/175619; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem