Category: 947249-14-1

14/9/2021 News Introduction of a new synthetic route about 947249-14-1

The chemical industry reduces the impact on the environment during synthesis 947249-14-1, I believe this compound will play a more active role in future production and life.

Reference of 947249-14-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.947249-14-1, name is 3-(Difluoromethoxy)pyridin-2-amine, molecular formula is C6H6F2N2O, molecular weight is 160.1215, as common compound, the synthetic route is as follows.

To a solution of 3-(difluoromethoxy)pyridin-2-amine (2.3 g, 14.36 mmol) in acetonitrile (15 was added N-bromosuccinimide (2.61 g, 14.65 mmol) over 3 min at 0 C. The reaction mixture was stirred at the same temperature for another 20 min and subsequently concentrated to dryness in vacuo. The resulting viscous mass was diluted with water and extracted with ethyl acetate (3 x 60 mL). The combined organic layers were dried over sodium sulfate and concentrated to dryness in vacuo. The resulting residue was purified by column chromatography (silica gel, 100-200 mesh, 20% ethyl acetate in hexane) affording 5-bromo-3-(difluoromethoxy)pyridin-2-amine (3.2 g, 93%): NMR (400 MHz, DMSO-d6) delta 7.89 (s, 1H), 7.51 (s, 1H), 7.16 (t, / = 73.6 Hz, 1H), 6.34 (s, 2H).

The chemical industry reduces the impact on the environment during synthesis 947249-14-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; LIU, Wen; PATEL, Snahel; SIU, Michael; WO2014/111496; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on Reference of 947249-14-1

Statistics shows that 947249-14-1 is playing an increasingly important role. we look forward to future research findings about 3-(Difluoromethoxy)pyridin-2-amine.

Reference of 947249-14-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.947249-14-1, name is 3-(Difluoromethoxy)pyridin-2-amine, molecular formula is C6H6F2N2O, molecular weight is 160.1215, as common compound, the synthetic route is as follows.

To a solution of 3-(difluoromethoxy)pyridin-2-amine (2.3 g, 14.36 mmol) in acetonitrile (15 mL) was added N-bromosuccinimide (2.61 g, 14.65 mmol) over 3 mm at 0 C. The reaction mixture was stirred at the same temperature for another 20 mm and subsequently concentrated to dryness in vacuo. The resulting viscous mass was diluted with water and extracted with ethyl acetate (3 x 60 mL). The combined organic layers were driedover sodium sulfate and concentrated to dryness in vacuo. The resulting residue was purified by column chromatography (silica gel, 100-200 mesh, 20% ethyl acetate in hexane) affording 5-bromo-3-(difluoromethoxy)pyridin-2-amine (3.2 g, 93%): 1H NMR (400 MHz, DMSO-d6) oe: 7.89 (s, 1H), 7.51 (s, 1H), 7.16 (t, I = 73.6 Hz, 1H), 6.34 (s, 2H).

Statistics shows that 947249-14-1 is playing an increasingly important role. we look forward to future research findings about 3-(Difluoromethoxy)pyridin-2-amine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; LYSSIKATOS, Joseph P.; LIU, Wen; SIU, Michael; ESTRADA, Anthony; PATEL, Snahel; LIANG, Guibai; HUESTIS, Malcolm; CHEN, Kevin; WO2015/91889; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem