Category: 948552-36-1

Reference of 1H-Pyrazole-5-carbaldehyde. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.

The synthesis and structure-activity studies of a series of quinoline-3-carbonitriles as inhibitors of Tpl2 kinase are described. Potent inhibitors of Tpl2 kinase with selectivity against a panel of selected kinases in enzymic assays and specificity in cell-based phosphorylation assays in LPS-treated human monocytes were identified. Selected inhibitors with moderate activity in human whole blood assay effectively inhibited LPS/D-Gal induced TNFα release when administered i.p. in mice.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C4H4N2O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Highly sensitive ruthenium complex-based fluorescent probe for copper ion detection. Author is Xia, Xiao Li; Zhang, Dao Bin; Zhang, Jiu Long; Pu, Shou Zhi.

A Ru(II) complex 1 ([Ru(bpy)2(L)](PF6)2 (L = 2-(1H-pyrazol-5-yl)-1H-imidazo-[4,5-f] [1,10] phenanthroline, bpy = 2,2′-bipyridine)), which included adjacent imidazole and pyrazole moieties as responsive bidentate ligand, had been designed and synthesized as a ‘turn-off’ fluorescent probe for sensitively and selectively detecting Cu2+ in methanol and test strips. It displayed easy synthesis, large Stokes shift (178 nm) and long emission wavelength (633 nm). After addition of Cu2+, the probe 1 exhibited obvious fluorescence quenching (ca. 83%) and color change from red to dark. The detection limit of Cu2+ ions was as low as 1.78 x 10-8 M, which was far lower than the permissible level of copper ion (∼20μM) in drinking water set by the EPA (Environmental Protection Agency). Moreover, the results of test strip experiments and real water sample detection experiments demonstrated the probe 1 possesses potential application of ions recognition in environment.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Deters, Ria; Kramer, Roland published an article about the compound: 1H-Pyrazole-5-carbaldehyde( cas:948552-36-1,SMILESS:O=CC1=CC=NN1 ).Quality Control of 1H-Pyrazole-5-carbaldehyde. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:948552-36-1) through the article.

The new ligand N,N ‘-bis(pyrazol-3-ylmethyl)-1,2-ethanediamine (L) was prepared Reaction with Cu(II) salts afforded [(L)Cu(NO3)]Cl (1) and {[(L)Cu(ClO4)]2[(pzen-H)2Cu2(ClO4)2]}(ClO4)2 (3) which were characterized by x-ray crystallog. The latter complex was obtained in low yield from a crude sample of L which contained N-(pyrazol-3-ylmethyl)-1,2-ethanediamine (pzen) as an impurity. In the [(L)Cu(X)]+ cations square-pyramidal Cu(II) is in-plane coordinated by tetradentate L, with the anion X in the apical position. The Cu ions in dinuclear [(pzen-H)2Cu2(ClO4)2] are bis(pyrazolate) bridged. In aqueous solution [(L)Cu]2+ is in pH-dependent equilibrium with a dimeric species. By precipitation with NaClO4 both monomeric [(L)Cu(ClO4)2] (2) and dimeric [(L-H)2Cu2(ClO4)2] (4) were isolable at pH 4.5 and pH 8.5, resp. Based on spectroscopic and anal. data probably 4 is a bis(pyrazolate) bridged complex in solution and in the solid state.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of a potent glutathione peroxidase 4 inhibitor as a selective ferroptosis inducer, published in 2021-09-23, which mentions a compound: 948552-36-1, mainly applied to chloroacetyl anilino arylacetamide ferroptosis inducer preparation antitumor activity; glutathione peroxidase inhibitor structure activity relationship, Name: 1H-Pyrazole-5-carbaldehyde.

Potent and selective ferroptosis regulators promote an intensive understanding of the regulation and mechanisms underlying ferroptosis, which is highly associated with various diseases. In this study, through a stepwise structure optimization, a potent and selective ferroptosis inducer was developed targeting to inhibit glutathione peroxidase 4 (GPX4), and the structure-activity relationship (SAR) of these compounds I [R1 = allyl, cyclohexyl, allyl, etc.; n = 0 and 1], II [wherein, Het = 1H-pyrazol-3-yl, 2-methylpyrazol-3-yl, 1H-indol-4-yl, etc.] and III [X = N and S; R2 = fluoro, methoxy, 5-methyloxazolyl, etc.] was uncovered. Compound III [X = S; R2 = 5-methyloxazolyl] exhibited outstanding GPX4 inhibitory activity with a percent inhibition up to 71.7% at 1.0 μM compared to 45.9% of RSL-3. At the cellular level, III [X = S; R2 = 5-methyloxazolyl] could significantly induce lipid peroxide (LPO) increase and effectively induce ferroptosis with satisfactory selectivity (the value of 31.5). The morphol. anal. confirmed the ferroptosis induced by III [X = S; R2 = 5-methyloxazolyl]. Furthermore, III [X = S; R2 = 5-methyloxazolyl] significantly restrained tumor growth in a mouse 4T1 xenograft model without obvious toxicity.

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Pyridine – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Pocar, Donato; Stradi, Riccardo researched the compound: 1H-Pyrazole-5-carbaldehyde( cas:948552-36-1 ).Synthetic Route of C4H4N2O.They published the article 《Studies in the enamine field. XXXVII. Diene amines and arylsulfonyl azides》 about this compound( cas:948552-36-1 ) in Annali di Chimica (Rome, Italy). Keywords: diene amines sulfonyl azides pyrazoles; diazo propenes cyclization pyrazoles. We’ll tell you more about this compound (cas:948552-36-1).

Pyrazoles are prepared from amines RCH:CHCH:CHNR1R2 (I) and sulfonyl azides p-R3C6H4SO2N3 (II); formamidines p-R3C6H4SO2N:CHNR1R2 are by-products. The pyrazoles are formed by cyclization of diazo compounds RCH:CHCHN2. Thus, 1-diethylamino-1,3-butadiene is treated with p-ClC6H4SO2N3 at 0-10° to give pyrazole (III); p-ClC6H4SO2N:CHNEt2 is isolated. Similarly, IV and V are prepared from I (R = CHO, R1 = Me, R2 = Ph) and I (R = CH2OH, R1 = Me, R2 = Ph) and II (R3 = Me, NO2).

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Pyridine – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Iron(II) complexes of new hexadentate 1,1,1-tris-(iminomethyl)ethane podands, and their 7-methyl-1,3,5-triazaadamantane rearrangement products, published in 2012, which mentions a compound: 948552-36-1, mainly applied to pyridylmethylene triazaadamantane iron complex preparation crystal structure; iron heterocyclic aldehyde aminomethyl methyldiaminopropane Schiff complex preparation structure, Quality Control of 1H-Pyrazole-5-carbaldehyde.

New iron(II) podand complexes were prepared, by condensation of 2-(aminomethyl)-2-methyl-1,3-diaminopropane with 3 equiv of a heterocyclic aldehyde in the presence of hydrated Fe[BF4]2 or Fe[ClO4]2 as templates. The 2-(aminomethyl)-2-methyl-1,3-diaminopropane was prepared in situ by deprotonation of its trihydrochloride salt. The chloride must be removed from these reactions by precipitation with silver, to avoid the formation of the alternative 2,4,6-trisubstituted-7-methyl-1,3,5-triazaadamantane condensation products, or their FeCl2 adducts. The crystal structures of two 2,4,6-tri(pyridyl)-7-methyl-1,3,5-triazaadamantane-containing species are presented, and contain two different geometric isomers of this tricyclic ring with three equatorial, or two equatorial and one axial, pyridyl substituents. Both structures feature strong C-H···X (X = Cl or F) hydrogen bonding from the aminal C-H groups in the triazaadamantane ring. Five iron(II) podand complexes were successfully obtained, all of which contain low-spin iron centers, and three of which were characterized by x-ray crystallog.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Benson, Nicole; Davis, Adam; Woydziak, Zachary R. published an article about the compound: 1H-Pyrazole-5-carbaldehyde( cas:948552-36-1,SMILESS:O=CC1=CC=NN1 ).Application In Synthesis of 1H-Pyrazole-5-carbaldehyde. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:948552-36-1) through the article.

Methine-bridged conjugated bicyclic aromatic compounds are common constituents of a range of biol. relevant mols. such as porphyrins, dipyrrinones, and pharmaceuticals. Addnl., restricted rotation of these systems often results in highly to moderately fluorescent systems as observed in 3H,5H-dipyrrolo[1,2-c:2”,1”-f]pyrimidin-3-ones, xanthoglows, pyrroloindolizinedione analogs, BODIPY analogs, and the phenolic and imidazolinone ring systems of Green Fluorescent Protein (GFP). This manuscript describes an inexpensive and operationally simple method of performing a Claisen-Schmidt condensation to generate a series of fluorescent pH dependent pyrazole/imidazole/isoindolone dipyrrinone analogs. While the methodol. illustrates the synthesis of dipyrrinone analogs, it can be translated to produce a wide range of conjugated bicyclic aromatic compounds The Claisen-Schmidt condensation reaction utilized in this method is limited in scope to nucleophiles and electrophiles that are enolizable under basic conditions (nucleophile component) and non-enolizable aldehydes (electrophile component). Addnl., both the nucleophilic and electrophilic reactants must contain functional groups that will not inadvertently react with hydroxide. Despite these limitations, this methodol. offers access to completely novel systems that can be employed as biol. or mol. probes.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 948552-36-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Cytotoxic activity of new neodymium (III) complexes of bis-coumarins. Author is Kostova, Irena; Manolov, Ilia; Momekov, Georgi.

Neodymium(III) complexes with methylenebis(coumarins) I (R = Ph, 2-pyridyl, 4-pyridyl, 3-pyrazolyl) were synthesized by reaction of Nd(III) salt and the ligands in metal:ligand molar ratio of 1:2. The complexes were prepared by adding an aqueous solution of Nd(III) salt to an aqueous solution of the ligand and subsequently raising the pH of the mixture gradually to ∼5.0 by adding a dilute solution of NaOH. The Nd(III) complexes with bis-coumarins were characterized by different physicochem. methods: elemental anal., IR-, 1H- and 13C-NMR-spectroscopies and mass-spectral data. The spectral data of the Nd(III) complexes were interpreted from comparison with the spectra of the free ligands. This anal. showed that in the Nd(III) complexes the ligands coordinated to the metal ion through both deprotonated hydroxyl groups. From the ν(C:O) red shift observed, participation of the carbonyl groups in the coordination to the metal ion was also suggested. Cytotoxic screening by MTT assay was carried out. The complexes were tested on HL-60, HL-60/Dox and lymphoid SKW-3 cell lines. The overall results from the preliminary screening program revealed that all of the new Nd(III) complexes reach 50% inhibition of the malignant cells proliferation and thus could be considered as biol. active. From the IC50 values obtained, compounds Nd(L1)(OH)·H2O and Nd(L3)(OH)·2H2O exert superior activity in comparison to the remaining complexes.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 948552-36-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Visible-Light-Driven Bisfunctionalization of Unactivated Olefins via the Merger of Proton-Coupled Electron Transfer and Carbene Catalysis. Author is Zhang, Bei; Qi, Jian-Qing; Liu, Yuhan; Li, Zhipeng; Wang, Jian.

Herein, the authors report an N-heterocyclic carbene (NHC) and photo-co-catalyzed alkylacylation of olefins in the presence of the versatile synthon diazo ester, providing a new idea for transient radical generation with the only byproduct being N2. Particularly, this radical process employs traditional carbene precursor diazo esters as the radical source, which is the first case in NHC catalysis. Compared to the previous pathway that produces radicals with large discard fragments, this merged channel possesses great atom economy.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C4H4N2O. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Alkaline polymers of intrinsic microporosity: high-conduction and low-loss anhydrous proton exchange membranes for energy conversion. Author is Zhou, Shengyang; Guan, Jiayu; Li, Ziqin; Huang, Lei; Zheng, Jifu; Li, Shenghai; Zhang, Suobo.

The development of anhydrous high-temperature proton-exchange membranes (HT-PEMs) combining durable high proton conductivity and modest mech. properties is a huge challenge to macromol. design and engineering. HT-PEMs with microporous structures, constructed by the inefficient chain packing of contorted and rigid polymer backbones with imidazole, are reported for the first time. It is found that the widespread and interconnected microporosity of the polymers endows the HT-PEMs with an excellent phosphoric acid (PA) doping level (ADL) and a corresponding superhigh proton conductivity, as well as suitable mech. properties and PA-retention ability. An outstanding proton conductivity of 330.3 mS cm-1 is obtained at 180 °C under an anhydrous atm., which is superior to those of reported HT-PEMs with far higher ADLs (<260 mS cm-1). The high and stable proton conductivity appears to be related to the interconnected intrinsic microporosity, which increases the PA storage and provides proton-carriers with several highways for fast transport. I hope my short article helps more people learn about this compound(1H-Pyrazole-5-carbaldehyde)Formula: C4H4N2O. Apart from the compound(948552-36-1), you can read my other articles to know other related compounds.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem