Category: 948552-36-1

Recommanded Product: 1H-Pyrazole-5-carbaldehyde. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance. Author is Schwarz, Maria; Eno, Rebecca F. M.; Freitag-Pohl, Stefanie; Coxon, Christopher R.; Straker, Hannah E.; Wortley, David J.; Hughes, David J.; Mitchell, Glynn; Moore, Jenny; Cummins, Ian; Onkokesung, Nawaporn; Brazier-Hicks, Melissa; Edwards, Robert; Pohl, Ehmke; Steel, Patrick G..

The evolution and growth of multiple-herbicide resistance (MHR) in grass weeds continues to threaten global cereal production While various processes can contribute to resistance, earlier work has identified the phi class glutathione-S-transferase (AmGSTF1) as a functional biomarker of MHR in black-grass (Alopecurus myosuroides). This study provides further insights into the role of AmGSTF1 in MHR using a combination of chem. and structural biol. Crystal structures of wild-type AmGSTF1, together with two specifically designed variants that allowed the co-crystal structure determination with glutathione and a glutathione adduct of the AmGSTF1 inhibitor 4-chloro-7-nitro-benzofurazan (NBD-Cl) were obtained. These studies demonstrated that the inhibitory activity of NBD-Cl was associated with the occlusion of the active site and the impediment of substrate binding. A search for other selective inhibitors of AmGSTF1, using ligand-fishing experiments, identified a number of flavonoids as potential ligands. Subsequent experiments using black-grass extracts discovered a specific flavonoid as a natural ligand of the recombinant enzyme. A series of related synthetic flavonoids was prepared and their binding to AmGSTF1 was investigated showing a high affinity for derivatives bearing a O-5-decyl-α-carboxylate. Mol. modeling based on high-resolution crystal structures allowed a binding pose to be defined which explained flavonoid binding specificity. Crucially, high binding affinity was linked to a reversal of the herbicide resistance phenotype in MHR black-grass. Collectively, these results present a nature-inspired new lead for the development of herbicide synergists to counteract MHR in weeds.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Pocar, Donato; Stradi, Riccardo researched the compound: 1H-Pyrazole-5-carbaldehyde( cas:948552-36-1 ).Synthetic Route of C4H4N2O.They published the article 《Studies in the enamine field. XXXVII. Diene amines and arylsulfonyl azides》 about this compound( cas:948552-36-1 ) in Annali di Chimica (Rome, Italy). Keywords: diene amines sulfonyl azides pyrazoles; diazo propenes cyclization pyrazoles. We’ll tell you more about this compound (cas:948552-36-1).

Pyrazoles are prepared from amines RCH:CHCH:CHNR1R2 (I) and sulfonyl azides p-R3C6H4SO2N3 (II); formamidines p-R3C6H4SO2N:CHNR1R2 are by-products. The pyrazoles are formed by cyclization of diazo compounds RCH:CHCHN2. Thus, 1-diethylamino-1,3-butadiene is treated with p-ClC6H4SO2N3 at 0-10° to give pyrazole (III); p-ClC6H4SO2N:CHNEt2 is isolated. Similarly, IV and V are prepared from I (R = CHO, R1 = Me, R2 = Ph) and I (R = CH2OH, R1 = Me, R2 = Ph) and II (R3 = Me, NO2).

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Pyridine – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Iron(II) complexes of new hexadentate 1,1,1-tris-(iminomethyl)ethane podands, and their 7-methyl-1,3,5-triazaadamantane rearrangement products, published in 2012, which mentions a compound: 948552-36-1, mainly applied to pyridylmethylene triazaadamantane iron complex preparation crystal structure; iron heterocyclic aldehyde aminomethyl methyldiaminopropane Schiff complex preparation structure, Quality Control of 1H-Pyrazole-5-carbaldehyde.

New iron(II) podand complexes were prepared, by condensation of 2-(aminomethyl)-2-methyl-1,3-diaminopropane with 3 equiv of a heterocyclic aldehyde in the presence of hydrated Fe[BF4]2 or Fe[ClO4]2 as templates. The 2-(aminomethyl)-2-methyl-1,3-diaminopropane was prepared in situ by deprotonation of its trihydrochloride salt. The chloride must be removed from these reactions by precipitation with silver, to avoid the formation of the alternative 2,4,6-trisubstituted-7-methyl-1,3,5-triazaadamantane condensation products, or their FeCl2 adducts. The crystal structures of two 2,4,6-tri(pyridyl)-7-methyl-1,3,5-triazaadamantane-containing species are presented, and contain two different geometric isomers of this tricyclic ring with three equatorial, or two equatorial and one axial, pyridyl substituents. Both structures feature strong C-H···X (X = Cl or F) hydrogen bonding from the aminal C-H groups in the triazaadamantane ring. Five iron(II) podand complexes were successfully obtained, all of which contain low-spin iron centers, and three of which were characterized by x-ray crystallog.

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Pyridine – Wikipedia,
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Benson, Nicole; Davis, Adam; Woydziak, Zachary R. published an article about the compound: 1H-Pyrazole-5-carbaldehyde( cas:948552-36-1,SMILESS:O=CC1=CC=NN1 ).Application In Synthesis of 1H-Pyrazole-5-carbaldehyde. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:948552-36-1) through the article.

Methine-bridged conjugated bicyclic aromatic compounds are common constituents of a range of biol. relevant mols. such as porphyrins, dipyrrinones, and pharmaceuticals. Addnl., restricted rotation of these systems often results in highly to moderately fluorescent systems as observed in 3H,5H-dipyrrolo[1,2-c:2”,1”-f]pyrimidin-3-ones, xanthoglows, pyrroloindolizinedione analogs, BODIPY analogs, and the phenolic and imidazolinone ring systems of Green Fluorescent Protein (GFP). This manuscript describes an inexpensive and operationally simple method of performing a Claisen-Schmidt condensation to generate a series of fluorescent pH dependent pyrazole/imidazole/isoindolone dipyrrinone analogs. While the methodol. illustrates the synthesis of dipyrrinone analogs, it can be translated to produce a wide range of conjugated bicyclic aromatic compounds The Claisen-Schmidt condensation reaction utilized in this method is limited in scope to nucleophiles and electrophiles that are enolizable under basic conditions (nucleophile component) and non-enolizable aldehydes (electrophile component). Addnl., both the nucleophilic and electrophilic reactants must contain functional groups that will not inadvertently react with hydroxide. Despite these limitations, this methodol. offers access to completely novel systems that can be employed as biol. or mol. probes.

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Pyridine – Wikipedia,
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HPLC of Formula: 948552-36-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Cytotoxic activity of new neodymium (III) complexes of bis-coumarins. Author is Kostova, Irena; Manolov, Ilia; Momekov, Georgi.

Neodymium(III) complexes with methylenebis(coumarins) I (R = Ph, 2-pyridyl, 4-pyridyl, 3-pyrazolyl) were synthesized by reaction of Nd(III) salt and the ligands in metal:ligand molar ratio of 1:2. The complexes were prepared by adding an aqueous solution of Nd(III) salt to an aqueous solution of the ligand and subsequently raising the pH of the mixture gradually to ∼5.0 by adding a dilute solution of NaOH. The Nd(III) complexes with bis-coumarins were characterized by different physicochem. methods: elemental anal., IR-, 1H- and 13C-NMR-spectroscopies and mass-spectral data. The spectral data of the Nd(III) complexes were interpreted from comparison with the spectra of the free ligands. This anal. showed that in the Nd(III) complexes the ligands coordinated to the metal ion through both deprotonated hydroxyl groups. From the ν(C:O) red shift observed, participation of the carbonyl groups in the coordination to the metal ion was also suggested. Cytotoxic screening by MTT assay was carried out. The complexes were tested on HL-60, HL-60/Dox and lymphoid SKW-3 cell lines. The overall results from the preliminary screening program revealed that all of the new Nd(III) complexes reach 50% inhibition of the malignant cells proliferation and thus could be considered as biol. active. From the IC50 values obtained, compounds Nd(L1)(OH)·H2O and Nd(L3)(OH)·2H2O exert superior activity in comparison to the remaining complexes.

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Formula: C4H4N2O. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Alkaline polymers of intrinsic microporosity: high-conduction and low-loss anhydrous proton exchange membranes for energy conversion. Author is Zhou, Shengyang; Guan, Jiayu; Li, Ziqin; Huang, Lei; Zheng, Jifu; Li, Shenghai; Zhang, Suobo.

The development of anhydrous high-temperature proton-exchange membranes (HT-PEMs) combining durable high proton conductivity and modest mech. properties is a huge challenge to macromol. design and engineering. HT-PEMs with microporous structures, constructed by the inefficient chain packing of contorted and rigid polymer backbones with imidazole, are reported for the first time. It is found that the widespread and interconnected microporosity of the polymers endows the HT-PEMs with an excellent phosphoric acid (PA) doping level (ADL) and a corresponding superhigh proton conductivity, as well as suitable mech. properties and PA-retention ability. An outstanding proton conductivity of 330.3 mS cm-1 is obtained at 180 °C under an anhydrous atm., which is superior to those of reported HT-PEMs with far higher ADLs (<260 mS cm-1). The high and stable proton conductivity appears to be related to the interconnected intrinsic microporosity, which increases the PA storage and provides proton-carriers with several highways for fast transport. I hope my short article helps more people learn about this compound(1H-Pyrazole-5-carbaldehyde)Formula: C4H4N2O. Apart from the compound(948552-36-1), you can read my other articles to know other related compounds.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 948552-36-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Visible-Light-Driven Bisfunctionalization of Unactivated Olefins via the Merger of Proton-Coupled Electron Transfer and Carbene Catalysis. Author is Zhang, Bei; Qi, Jian-Qing; Liu, Yuhan; Li, Zhipeng; Wang, Jian.

Herein, the authors report an N-heterocyclic carbene (NHC) and photo-co-catalyzed alkylacylation of olefins in the presence of the versatile synthon diazo ester, providing a new idea for transient radical generation with the only byproduct being N2. Particularly, this radical process employs traditional carbene precursor diazo esters as the radical source, which is the first case in NHC catalysis. Compared to the previous pathway that produces radicals with large discard fragments, this merged channel possesses great atom economy.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1H-Pyrazole-5-carbaldehyde. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance. Author is Schwarz, Maria; Eno, Rebecca F. M.; Freitag-Pohl, Stefanie; Coxon, Christopher R.; Straker, Hannah E.; Wortley, David J.; Hughes, David J.; Mitchell, Glynn; Moore, Jenny; Cummins, Ian; Onkokesung, Nawaporn; Brazier-Hicks, Melissa; Edwards, Robert; Pohl, Ehmke; Steel, Patrick G..

The evolution and growth of multiple-herbicide resistance (MHR) in grass weeds continues to threaten global cereal production While various processes can contribute to resistance, earlier work has identified the phi class glutathione-S-transferase (AmGSTF1) as a functional biomarker of MHR in black-grass (Alopecurus myosuroides). This study provides further insights into the role of AmGSTF1 in MHR using a combination of chem. and structural biol. Crystal structures of wild-type AmGSTF1, together with two specifically designed variants that allowed the co-crystal structure determination with glutathione and a glutathione adduct of the AmGSTF1 inhibitor 4-chloro-7-nitro-benzofurazan (NBD-Cl) were obtained. These studies demonstrated that the inhibitory activity of NBD-Cl was associated with the occlusion of the active site and the impediment of substrate binding. A search for other selective inhibitors of AmGSTF1, using ligand-fishing experiments, identified a number of flavonoids as potential ligands. Subsequent experiments using black-grass extracts discovered a specific flavonoid as a natural ligand of the recombinant enzyme. A series of related synthetic flavonoids was prepared and their binding to AmGSTF1 was investigated showing a high affinity for derivatives bearing a O-5-decyl-α-carboxylate. Mol. modeling based on high-resolution crystal structures allowed a binding pose to be defined which explained flavonoid binding specificity. Crucially, high binding affinity was linked to a reversal of the herbicide resistance phenotype in MHR black-grass. Collectively, these results present a nature-inspired new lead for the development of herbicide synergists to counteract MHR in weeds.

I hope my short article helps more people learn about this compound(1H-Pyrazole-5-carbaldehyde)Recommanded Product: 1H-Pyrazole-5-carbaldehyde. Apart from the compound(948552-36-1), you can read my other articles to know other related compounds.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1H-Pyrazole-5-carbaldehyde. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Unprecedented copper(II)-assisted acetal formation of a formyl-substituted bispyrazole. The x-ray structures of copper[1,2-bis(3′-dimethoxymethylpyrazol-1′-yl)ethane] dichloride and dibromide. Author is Koval, Iryna A.; Schuitema, Anna M.; Driessen, Willem L.; Reedijk, Jan.

The formation of two new acetal-containing ligands 1,2-bis(3′-dimethoxymethylpyrazol-1′-yl)ethane (bdmpe) and 1,2-bis(3′-diethoxymethylpyrazol-1′-yl)ethane (bdepe) in a Cu(II)-assisted alcoholysis of the initial ligand 1,2-bis(3′-formylpyrazol-1′-yl)ethane is described. The new ligands form polymeric complexes with Cu(II) salts, [Cu(L)X2]x, where L = bdmpe or bdepe, and X = Cl or Br. The single-crystal x-ray structures of [Cu(bdmpe)Cl2]x and [Cu(bdmpe)Br2]x show that two of the four oxygen atoms of the acetal fragments are axially semi-coordinated to the copper(II) ions, adjusting the coordination sphere around the metal ion to a very distorted octahedron. The coordination of the oxygen atoms of the acetal groups to the metal ion may well be the driving force for the transformation of the initial aldehyde groups into the acetal fragments. The equatorial plane in [Cu(bdmpe)Cl2]x is a trans-CuN2Cl2 chromophore, while in [Cu(bdmpe)Br2]x it is a cis-CuN2Br2 species with a large in-plane distortion.

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Pyridine – Wikipedia,
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Radi, Smaail; Tighadouini, Said; Bacquet, Maryse; Degoutin, Stephanie; Cazier, Francine; Zaghrioui, Mustapha; Mabkhot, Yahia N. published an article about the compound: 1H-Pyrazole-5-carbaldehyde( cas:948552-36-1,SMILESS:O=CC1=CC=NN1 ).Related Products of 948552-36-1. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:948552-36-1) through the article.

A new chelating matrix, SiNP, has been prepared by immobilizing 1.5-dimethyl-1H-pyrazole-3-carbaldehyde on silica gel modified with 3-aminopropyl-trimethoxysilane. This new chelating material was well characterized by elemental anal., FT-IR spectroscopy, cross polarization magic angle spinning solid state 13C-NMR, nitrogen adsorption-desorption isotherm, BET surface area, BJH pore size, and SEM (SEM). The new product exhibits good chem. and thermal stability as determined by thermogravimetry curves (TGA). The new prepared material was used as an adsorbent for the solid-phase extraction (SPE) of Pb(II), Cd(II), Cu(II) and Zn(II) from aqueous solutions using a batch method, prior to their determination by flame at. adsorption spectrometry. The adsorption capacity was investigated using kinetics and pH effects. Common coexisting ions did not interfere with separation and determination

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Pyridine – Wikipedia,
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