Category: 953780-40-0

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.953780-40-0, name is Methyl 5-fluoro-6-methoxynicotinate, molecular formula is C8H8FNO3, molecular weight is 185.15, as common compound, the synthetic route is as follows.SDS of cas: 953780-40-0

A mixture of methyl 5-fluoro-6-methoxynicotinate (3.5 g, 18.9 mmol) and KOH (4.2 g, 61.5 mmol) in MeOH (70 ml) was stirred at room temperature for 5 h. After concentration, the residue was dissolved in water, and the obtained solution was washed with ether. The aqueous phase was acidified to pH = 1 with dilute hydrochloric acid, and extracted with ether, and the combined organic layers were washed with brine, dried over Na2SO4 and concentrated under vacuum to afford S-fluoro–methoxynicotinic acid (3.2g, 98%) as a white solid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,953780-40-0, Methyl 5-fluoro-6-methoxynicotinate, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; WO2007/120729; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.953780-40-0, name is Methyl 5-fluoro-6-methoxynicotinate, molecular formula is C8H8FNO3, molecular weight is 185.15, as common compound, the synthetic route is as follows.SDS of cas: 953780-40-0

A mixture of methyl 5-fluoro-6-methoxynicotinate (3.5 g, 18.9 mmol) and KOH (4.2 g, 61.5 mmol) in MeOH (70 ml) was stirred at room temperature for 5 h. After concentration, the residue was dissolved in water, and the obtained solution was washed with ether. The aqueous phase was acidified to pH = 1 with dilute hydrochloric acid, and extracted with ether, and the combined organic layers were washed with brine, dried over Na2SO4 and concentrated under vacuum to afford S-fluoro–methoxynicotinic acid (3.2g, 98%) as a white solid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,953780-40-0, Methyl 5-fluoro-6-methoxynicotinate, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; WO2007/120729; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 953780-40-0, Methyl 5-fluoro-6-methoxynicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

[00674] Intermediate 73d: 5-fluoro-6-methoxy-pyridine-3-carboxylic acid[00675] A solution of potassium hydroxide (885mg, 1 5.77mmol) and methyl 5-fluoro-6-methoxy- pyridine-3-carboxylate (730mg, 3.g4mmol) in MeOH (l5mL) was stirred at room temperature overnight. The solvent was removed in vacuo and the residue taken up in water (20 mL) andwashed with ether (2OmL). The aqueous phase was acidified to pH 2 with 1 M HCI and extracted with EtOAc (3 x 2OmL). The organic fractions were collected, washed with brine, dried (Na2504), filtered and reduced in vacuo to afford the desired product 5-fluoro-6-methoxy-pyridine-3-carboxylic acid (640mg, 3.74mmol, 95% yield) as a white solid.1H NMR (CDCI3,400MHz) O/ppm: 8.71 (1H, d, J= 1.9Hz), 7.95 (1H, dd, J= 10.2Hz, 1.9Hz), 4.14(3H,s).MS Method 2: RT: 1.47 mm, 171.9 m/z [M+H]

The synthetic route of 953780-40-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REDX PHARMA PLC; ARMER, Richard; BELFIELD, Andrew; BINGHAM, Matilda; JOHNSON, Alice; MARGATHE, Jean-Francois; AVERY, Craig; HUGHES, Shaun; MORRISON, Angus; (278 pag.)WO2016/51193; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem