Category: 956003-24-0

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 956003-24-0, name is 3-Iodo-1H-pyrrolo[2,3-c]pyridine, molecular formula is C7H5IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 956003-24-0

To a mixture of azaindole 1 (150 mg, 0.615 mmol) and 2-bromoethanol (115 mg, 0.923 mmol) in DMF (3 mL) is added K2C03 (170 mg, 1.23 mmol). The mixture is stirred at 40 C for 2 h then poured into water (30 mL), and extracted with EtOAc (50 mL x 3). The combined EtOAc is washed with brine, and concentrated in vacuo. The residue is purified by prep-HPLC to afford Example 25 (18 mg, yield= 6 %).

With the rapid development of chemical substances, we look forward to future research findings about 956003-24-0.

Reference:
Patent; DISARM THERAPEUTICS, INC.; HUGHES, Robert Owen; DEVRAJ, Rajesh; BOSANAC, Todd; JARJES-PIKE, Richard Andrew; BREARLEY, Andrew Simon; BENTLEY, Jonathan; (0 pag.)WO2019/236884; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

956003-24-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 956003-24-0 as follows.

Preparation of 1-methyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1H-pyrrolo[2,3-c]pyridine (?A33?) 7.17 g (22 mmol) of caesium carbonate and 3.12 g (22 mmol) of iodomethane are added successively to a solution of 4.88 g (20 mmol) of 3-iodo-1H-pyrrolo[2,3-c]pyridine in 45 ml of acetonitrile. The reaction mixture is stirred at room temperature for 18 hours and subsequently filtered. The filtrate is evaporated, and the residue is chromatographed on a silicagel column with dichloromethane/methanol as eluent, giving two isomers: 3-iodo-1-methyl-1H-pyrrolo[2,3-c]pyridine as colourless crystals, [0323] 1H NMR (400 MHz, DMSO-d6) delta [ppm]=8.83 (s, 1H), 8.23 (d, J=5.5, 1H), 7.77 (s, 1H), 7.24 (dd, J=5.5, 1.0, 1H), 3.93 (s, 3H); [0324] 3-iodo-6-methyl-6H-pyrrolo[2,3-c]pyridine as brown solid, [0325] 1H NMR (400 MHz, DMSO-d6) delta [ppm]=9.21 (s, 1H), 8.45 (s, 1H), 8.37 (d, J=6.5, 1H), 7.81 (d, J=6.6, 1H), 4.39 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 956003-24-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK PATENT GMBH; Dorsch, Dieter; Sirrenberg, Christian; Mueller, Thomas J.J.; Merkul, Eugen; Karapetyan, Gnuni Amatunu; US2013/310391; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem