Application of 958358-00-4 ,Some common heterocyclic compound, 958358-00-4, molecular formula is C8H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Di-tert-butyl dicarbonate (2.45 g) was added in one portion to a mixture of 5-bromo- 6-methyl-lH-pyrrolo[2,3-b]pyridine (1.97g) and methylene chloride (100 ml). 4-Dimethylaminopyridine (0.011 g) was added and the reaction mixture was stirred at ambient temperature for 16 hours. The resultant mixture was evaporated and the residual oil was purified by column chromatography on silica using a 5:1 mixture of isohexane and methanol as eluent. There was thus obtained 5-bromo-l-fert-butoxycarbonyl-6-methyl- lH-rhoyrrolo[2,3-b]rhoyridine as a solid (2.34 g); 1H NMR Spectrum: (DMSOd6) 1.62 (s, 9H), 2.66 (s, 3H), 6.63 (d, IH), 7.75 (d, IH), 8.27 (s, IH); Mass Spectrum: M+H1″ 309.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,958358-00-4, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/135398; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem