Related Products of 960299-32-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 960299-32-5, name is 3-Bromo-6-chloro-1-methylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below.
A mixture of 27.28 g of 3-bromo-6-chloro-1-methylpyridin-2 (1H) -one, 47.94 g of cesium carbonate and 100 mL of DMF was cooled with ice.19.32 g of 2,2,3,3,3-pentafluoro-1-propanol was added dropwise and stirred at room temperature for 3 hours. To the resulting mixture was added water and extracted with ethyl acetate. The obtained organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue obtained is washed successively with water and hexane and is shown below39.41 g of Intermediate A-28 was obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,960299-32-5, 3-Bromo-6-chloro-1-methylpyridin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Sumitomo Chemical Co., Ltd.; Murakami, Shinichiro; (468 pag.)JP2019/65018; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem