Reference of 96166-00-6 ,Some common heterocyclic compound, 96166-00-6, molecular formula is C12H12N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A toluene solution (331 g) of the obtained 2-amino-5-benzyloxypyridine,Ethanol (217 g) and 10% Pd / C (2.28 g, moisture content 53%) were charged in an autoclave and reacted at 25 C. for 4 hours while being introduced at 0.2 MPa (absolute pressure) in a hydrogen atmosphere.After completion of the reaction, Pd / C was filtered and the residue was washed with ethanol (76 g).The filtrate was dried under reduced pressure to obtain 2-amino-5-hydroxypyridine (25.6 g, 0.23 mol) (yield 92%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 96166-00-6, 5-(Benzyloxy)pyridin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; KOEI CHEMICAL COMPANY LIMITED; TAKAHASHI, SATOSHI; NIHEI, YURI; (24 pag.)JP2017/48131; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem