Category: 96568-04-6

Adding a certain compound to certain chemical reactions, such as: 96568-04-6, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate, blongs to pyridine-derivatives compound. Application In Synthesis of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate

[ETHYL-3- (2, 6-DICHLORO-5-FLUOROPYRIDINYL)-3-OXO-PROPANOATE] (5 g, 18 mmol) is mixed with triethyl orthofomate (4.3 [ML,] 26 mmol) and acetic anhydride (4.1 [ML,] 43 mmol) and the mixture is heated at reflux for 2 hours. The mixture is then concentrated under vacuum to afford the desired product.

The synthetic route of 96568-04-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE PROCTER & GAMBLE COMPANY; WO2004/14893; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 96568-04-6 , The common heterocyclic compound, 96568-04-6, name is Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate, molecular formula is C10H8Cl2FNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: 4.1.4.1. 5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one (17)A solution of intermediate 5a (0.227 g, 1 mmol) and ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate (0.28 g, 1 mmol) in acetic acid (8 ml) was added to a teat glass (40 ml) of Syncore Reactor, keeping the temperature at 125 C and the rotational speed of the device at 300 rpm for 4 h. After this period, the solvent of reaction was concentrated to half under reduced pressure by Syncore Polyvap, and cooled to about 15 C gradually. The mixture was filtered and the solid was washed with acetic acid and water to pH 7, to obtain the compound 17 (0.35 g, Yield: 80%, Purity: 98% by HPLC-DAD) as a white floccular solid. mp >300 C; ESI-Ms (m/z): 443.2 [M + H]+; 1H NMR (500 MHz, DMSO-d6) delta: 7.52 (m, 3H, Ph-H), 7.47 (m, 2H, Ph-H), 6.17 (s, 1H, 6-CH), 8.41 (d, 1H, J = 8, pyridine 4-CH), 12.90 (brs, 1H, NH); 13C NMR (125 MHz, DMSO-d6) delta: 99.33 (6-CH), 104.56 (3-C), 155.63 (7-CO), 152.57, 154.63 (5-C), 140.75 (2-C), 130.65 (Ph-C), 129.22 (Ph-C), 128.89 (Ph-C), 127.94 (Ph-C), 122.86 (CF3), 146.91 (pyridine-C), 142.59 (pyridine-C), 137.94 (pyridine-C), 130.44 (pyridine-C), 130.26 (pyridine-C); HRMS (ESI) calcd for C18H9Cl2F4N4O ([M + H]+), 443.0090; found 443.0085; IRvmax (KBr):1701 (CO), 1629, 1558, cm-1.

The synthetic route of 96568-04-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Qi, Jinlong; Zhang, Fan; Mi, Yi; Fu, Yan; Xu, Wen; Zhang, Diqun; Wu, Yibing; Du, Xiaona; Jia, Qingzhong; Wang, Kewei; Zhang, Hailin; European Journal of Medicinal Chemistry; vol. 46; 3; (2011); p. 934 – 943;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.96568-04-6, name is Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate, molecular formula is C10H8Cl2FNO3, molecular weight is 280.08, as common compound, the synthetic route is as follows.Safety of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate

Ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate (19.5 g, 69.6 mmol) and triethyl orthoformate (23.1 ml, 140 mmol) were initially charged in acetic anhydride (46 ml, 490 mmol) and the mixture was stirred at 140 C. overnight. The reaction mixture was then concentrated under reduced pressure and reacted further in the subsequent steps without further work-up. Quantitative conversion was assumed. LC-MS (Method 1): Rt=1.00 min; MS (ESIpos): m/z=336 [M+H]+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,96568-04-6, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate, and friends who are interested can also refer to it.

Reference:
Patent; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; TELLER, Henrik; VAKALOPOULOS, Alexandros; BOULTADAKIS ARAPINIS, Melissa; STRAUB, Alexander; TINEL, Hanna; BRECHMANN, Markus; WITTWER, Matthias Beat; KULLMANN, Maximilian Andreas; FREUDENBERGER, Till; MONDRITZKI, Thomas; MARQUARDT, Tobias; (165 pag.)US2019/263805; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 96568-04-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.96568-04-6, name is Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate, molecular formula is C10H8Cl2FNO3, molecular weight is 280.08, as common compound, the synthetic route is as follows.

Ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate (40 g) and triethyl orthoformate (26.1 mL) in acetic anhydride (100 mL) were stirred at 85 C. for 6.5 hours, cooled, and concentrated. The concentrate was crystallized from hexanes with a small amount of diethyl ether and dichloromethane.

Statistics shows that 96568-04-6 is playing an increasingly important role. we look forward to future research findings about Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate.

Reference:
Patent; Hinman, Mira M.; Rosenberg, Teresa A.; Wagner, Rolf; US2005/234053; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem