Category: 97509-75-6

Adding a certain compound to certain chemical reactions, such as: 97509-75-6, 3-Fluoropicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 97509-75-6, blongs to pyridine-derivatives compound. Product Details of 97509-75-6

Pre aration 86A: 3-Fluoro-4-iodopicolinonitrile[00297] To a solution of diisopropylamine (2.80 ml, 19.66 mmol) in THF (Volume: 201 ml) cooled to -78 °C was added n-butyllithium (7.86 ml, 19.66 mmol) dropwise. The dry ice/acetone bath was replaced with an ice water bath and reaction mixture was stirred at 0 °C for 25 min, and then re-cooled to -78 °C. In a separate flask, a solution of 3- fluoropicolinonitrile (1.5 g, 12.29 mmol) in THF (50 mL) was cooled to -78 °C, and then LDA (130 mL, 1.0 equiv) was added. The solution turned dark red. After 35 min, iodine (3.43 g, 13.51 mmol) was added rapidly. The reaction mixture was stirred for 45 min, then quenched with H20. Layers were separated and the aqueous phase extracted with CH2CI2 (2X). Organics combined, dried over Na2S04, filtered, and concentrated to afford a brown residue. The crude material was dissolved in a minimal amount of CH2CI2 to be chromatographed. Purification of the crude material by silica gel chromatography using an ISCO machine (80 g column, 60 mL/min, 0-20percent EtOAc in hexanes over 23 min, tr = 18 min) gave the title compound (1.7 g, 6.79 mmol, 55.2percent yield) as a brown solid.

The synthetic route of 97509-75-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; HUANG, Audris; VELAPARTHI, Upender; LIU, Peiying; WO2013/49263; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 97509-75-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 97509-75-6, name is 3-Fluoropicolinonitrile. A new synthetic method of this compound is introduced below.

The mixture of 3-fluoro-pyridine-2-carbonitrile (0.81 g,6.63 mmol) and Pd/C (0.20 g, 10percent wt) in 10 ml of MeOH and2.7 ml of concentrated HC1 was placed under H2 which wasprovided by a balloon and stirred at RT for 4 h, filteredthrough Celite.(R)., condensed, the residue was purified byflash column chromatography, 0.13 g of the titled compoundwas obtained as a light yellowish oil. MS(ES+): 127.1(M+H)+. Calc’d for C6H7PN2 – 126.13.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,97509-75-6, its application will become more common.

Reference:
Patent; AMGEN INC.; WO2006/12374; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem