Category: 97944-43-9

Electric Literature of 97944-43-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 97944-43-9, name is 3-Bromo-5-methylpyridin-4-amine, molecular formula is C6H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 1-38 (350 mg, 1.471 mmol), isoprenylboronic acid pinacol ester [126726- 62-3] (414.632 pL, 2.21 mmol) and Pd(PPh3)4 (169.937 mg, 0.15 mmol) in NaEC03 sat. solution (2 mL) and l,4-dioxane (3.76 mL, 44.1 mmol) was stirred and heated under nitrogen atmosphere for 15 min at 130 C in a MW. The mixture was treated with sat. NaHC03 and extracted with EtOAc. The organic layer was separated, dried (MgS04), filtered and the solvents were evaporated in vacuo. The product was purified flash column chromatography (silica, heptane/EtOAc, gradient from 100/0 to 50/50) to obtain 1-39 (205 mg, 92%) as a colourless oil.

According to the analysis of related databases, 97944-43-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; TRESADERN, Gary John; MARTINEZ LAMENCA, Carolina; LEENAERTS, Joseph Elisabeth; OEHLRICH, Daniel; BUIJNSTERS, Peter Jacobus Johannes Antonius; VELTER, Adriana, Ingrid; VAN ROOSBROECK, Yves, Emiel, Maria; (171 pag.)WO2019/243535; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 97944-43-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 97944-43-9, name is 3-Bromo-5-methylpyridin-4-amine, molecular formula is C6H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 1-38 (350 mg, 1.471 mmol), isoprenylboronic acid pinacol ester [126726- 62-3] (414.632 pL, 2.21 mmol) and Pd(PPh3)4 (169.937 mg, 0.15 mmol) in NaEC03 sat. solution (2 mL) and l,4-dioxane (3.76 mL, 44.1 mmol) was stirred and heated under nitrogen atmosphere for 15 min at 130 C in a MW. The mixture was treated with sat. NaHC03 and extracted with EtOAc. The organic layer was separated, dried (MgS04), filtered and the solvents were evaporated in vacuo. The product was purified flash column chromatography (silica, heptane/EtOAc, gradient from 100/0 to 50/50) to obtain 1-39 (205 mg, 92%) as a colourless oil.

According to the analysis of related databases, 97944-43-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; TRESADERN, Gary John; MARTINEZ LAMENCA, Carolina; LEENAERTS, Joseph Elisabeth; OEHLRICH, Daniel; BUIJNSTERS, Peter Jacobus Johannes Antonius; VELTER, Adriana, Ingrid; VAN ROOSBROECK, Yves, Emiel, Maria; (171 pag.)WO2019/243535; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 97944-43-9, Adding some certain compound to certain chemical reactions, such as: 97944-43-9, name is 3-Bromo-5-methylpyridin-4-amine,molecular formula is C6H7BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97944-43-9.

2.2 5-Methyl-[3,4′]bipyridinyl-4-ylamine A mixture of 3-bromo-5-methyl-pyridin-4-ylamine (1.00 g, 5.347 mmol), pyridin-4-yl boronic acid (0.65 g, 5.347 mmol), K2CO3 (2.22 g, 16.04 mmol) and Pd(dppf)Cl2 (436 mg, 0.5347 mmol) in water (3 mL) and 1,4-dioxane (15 mL) was stirred at 105 C. overnight. The mixture was diluted with EtOAc (100 mL) and washed with brine (30 mL*4). The organic layer was dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified on a silica column (EtOAc) to afford the title product as a white solid (554 mg, yield 56%). LCMS (ESI+): m/z 186 (M+H)+, Rt: 1.16 min.

According to the analysis of related databases, 97944-43-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Abbott Laboratories; Abbott GmbH & Co. KG; US2013/5705; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 97944-43-9, 3-Bromo-5-methylpyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 3-Bromo-5-methylpyridin-4-amine, blongs to pyridine-derivatives compound. Application In Synthesis of 3-Bromo-5-methylpyridin-4-amine

step 2 A suspension of 98 and toluene (100 mL) was heated to 110 C until the solid dissolved. The the warm solution was added TEA (30 mL, 0.216 mmol) and acetic anhydride (20.4 mL, 22. 1g, 0.216 mmol) and the reaction was heated for 3 h. An additional 30 mL of AC2O was added after 3 h and an additional 30 mL of TEA was added after 6 h. The solution was concentrated in vacuo and the residue dissolved in EtOAc (500 mL) and was twice with H20 (200 mL). The aqueous extracts were reextracted twice with EtOAc (200 mL) and the combined EtOAc extracts were dried (MGS04), filtered and evaporated to afford a brown oil. The crude product was purified by flash chromatography over Si02 (0 to 20% EtOAc/hexane) to afford impure yellow oil which was subjected to a second flash chromatography over SI02 (20 to 50% EtOAc/hexane) to afford 99 (12.1 g).

The synthetic route of 97944-43-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/16892; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 97944-43-9, 3-Bromo-5-methylpyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 3-Bromo-5-methylpyridin-4-amine, blongs to pyridine-derivatives compound. Application In Synthesis of 3-Bromo-5-methylpyridin-4-amine

step 2 A suspension of 98 and toluene (100 mL) was heated to 110 C until the solid dissolved. The the warm solution was added TEA (30 mL, 0.216 mmol) and acetic anhydride (20.4 mL, 22. 1g, 0.216 mmol) and the reaction was heated for 3 h. An additional 30 mL of AC2O was added after 3 h and an additional 30 mL of TEA was added after 6 h. The solution was concentrated in vacuo and the residue dissolved in EtOAc (500 mL) and was twice with H20 (200 mL). The aqueous extracts were reextracted twice with EtOAc (200 mL) and the combined EtOAc extracts were dried (MGS04), filtered and evaporated to afford a brown oil. The crude product was purified by flash chromatography over Si02 (0 to 20% EtOAc/hexane) to afford impure yellow oil which was subjected to a second flash chromatography over SI02 (20 to 50% EtOAc/hexane) to afford 99 (12.1 g).

The synthetic route of 97944-43-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/16892; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 97944-43-9, name is 3-Bromo-5-methylpyridin-4-amine. A new synthetic method of this compound is introduced below., Quality Control of 3-Bromo-5-methylpyridin-4-amine

A sealed tube was charged with 3-bromo-5-methylpyridin-4-amine [97944-43-9] (1.00 g, 4.26 mmol), isopropenylboronic acid pinacol ester [126726-62-3] (1.07 g, 6.34 mmol), Pd(PPh3)4 (507 mg, 0.43 mmol), l,4-dioxane (10 mL) and NaHCCL (sat., aq., 10 mL). The reaction mixture was stirred under reflux for 16 h, cooled down and diluted with water and DCM until clear phase separation. The aqueous phase was extracted with DCM. The combined organic extracts were dried (MgS04), filtered and concentrated in vacuo to afford 1-112 (1.77 g, 83%, 39% purity) which was sued as such in the next step

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 97944-43-9, 3-Bromo-5-methylpyridin-4-amine.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; TRESADERN, Gary John; MARTINEZ LAMENCA, Carolina; LEENAERTS, Joseph Elisabeth; OEHLRICH, Daniel; BUIJNSTERS, Peter Jacobus Johannes Antonius; VELTER, Adriana, Ingrid; VAN ROOSBROECK, Yves, Emiel, Maria; (171 pag.)WO2019/243535; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 97944-43-9, name is 3-Bromo-5-methylpyridin-4-amine. A new synthetic method of this compound is introduced below., Quality Control of 3-Bromo-5-methylpyridin-4-amine

A sealed tube was charged with 3-bromo-5-methylpyridin-4-amine [97944-43-9] (1.00 g, 4.26 mmol), isopropenylboronic acid pinacol ester [126726-62-3] (1.07 g, 6.34 mmol), Pd(PPh3)4 (507 mg, 0.43 mmol), l,4-dioxane (10 mL) and NaHCCL (sat., aq., 10 mL). The reaction mixture was stirred under reflux for 16 h, cooled down and diluted with water and DCM until clear phase separation. The aqueous phase was extracted with DCM. The combined organic extracts were dried (MgS04), filtered and concentrated in vacuo to afford 1-112 (1.77 g, 83%, 39% purity) which was sued as such in the next step

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 97944-43-9, 3-Bromo-5-methylpyridin-4-amine.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; TRESADERN, Gary John; MARTINEZ LAMENCA, Carolina; LEENAERTS, Joseph Elisabeth; OEHLRICH, Daniel; BUIJNSTERS, Peter Jacobus Johannes Antonius; VELTER, Adriana, Ingrid; VAN ROOSBROECK, Yves, Emiel, Maria; (171 pag.)WO2019/243535; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 97944-43-9, name is 3-Bromo-5-methylpyridin-4-amine. A new synthetic method of this compound is introduced below., Quality Control of 3-Bromo-5-methylpyridin-4-amine

A sealed tube was charged with 3-bromo-5-methylpyridin-4-amine [97944-43-9] (1.00 g, 4.26 mmol), isopropenylboronic acid pinacol ester [126726-62-3] (1.07 g, 6.34 mmol), Pd(PPh3)4 (507 mg, 0.43 mmol), l,4-dioxane (10 mL) and NaHCCL (sat., aq., 10 mL). The reaction mixture was stirred under reflux for 16 h, cooled down and diluted with water and DCM until clear phase separation. The aqueous phase was extracted with DCM. The combined organic extracts were dried (MgS04), filtered and concentrated in vacuo to afford 1-112 (1.77 g, 83%, 39% purity) which was sued as such in the next step

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 97944-43-9, 3-Bromo-5-methylpyridin-4-amine.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; TRESADERN, Gary John; MARTINEZ LAMENCA, Carolina; LEENAERTS, Joseph Elisabeth; OEHLRICH, Daniel; BUIJNSTERS, Peter Jacobus Johannes Antonius; VELTER, Adriana, Ingrid; VAN ROOSBROECK, Yves, Emiel, Maria; (171 pag.)WO2019/243535; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 97944-43-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 97944-43-9, name is 3-Bromo-5-methylpyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 3-bromo-5-methylpyridine-4-amine (5.00 g, 27 mmol), (0231) isopropenylboronic acid pinacol ester (6.70 g, 40 mmol), Pd(PPh3)4 (3.20 g, 2.70 mmol), l,4-dioxane (50 mL), and NaHCCh (sat. aq., 50 mL) was stirred under reflux for 16 h. Then the suspension was cooled and diluted with water and DCM until clear phase separation. The aqueous phase was extracted with DCM. The combined organic extracts were dried (MgS04), filtered and concentrated under reduced pressure. The crude mixture was purified by flash column chromatography (silica, mobile phase gradient: 0-3% 7N NFT/McOH in DCM). The residue was combined with another fraction (1.5 g) and dissolved in z-PrOH (20 mL). The mixture was treated with HC1 (6M in z-PrOH, 9 mL, 54 mmol) and stirred over the weekend. The mixture was ice- cooled and the product was collected by filtration to afford 1-67 (4.5 g, 76%) as a white solid.

According to the analysis of related databases, 97944-43-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; LEENAERTS, Joseph, Elisabeth; OEHLRICH, Daniel; BUIJNSTERS, Peter Jacobus Johannes Antonius; MARTINEZ LAMENCA, Carolina; VELTER, Adriana, Ingrid; VAN ROOSBROECK, Yves, Emiel, Maria; (110 pag.)WO2019/243533; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem