Category: 98-98-6

The author of 《Poly(amidoamine) Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for the Radiotherapy-Enhanced Magnetic Resonance Imaging and Chemotherapy of Tumors and Tumor Metastasis》 were Fan, Yu; Zhang, Jiulong; Shi, Menghan; Li, Dan; Lu, Chunhua; Cao, Xueyan; Peng, Chen; Mignani, Serge; Majoral, Jean-Pierre; Shi, Xiangyang. And the article was published in Nano Letters in 2019. Product Details of 98-98-6 The author mentioned the following in the article:

The development of a powerful nanoplatform to realize the simultaneous therapy and diagnosis of cancer using a similar element for theranostics remains a critical challenge. Herein, we report such a theranostic nanoplatform based on pyridine (Pyr)-functionalized generation 5 (G5) poly(amidoamine) dendrimers complexed with copper(II) (Cu(II)) for radiotherapy-enhanced T1-weighted magnetic resonance (MR) imaging and the synergistic radio-chemotherapy of both tumors and tumor metastasis. In this study, amine-terminated G5 dendrimers were covalently linked with 2-pyridinecarboxylic acid, acetylated to neutralize their remaining terminal amines, and complexed with Cu(II) through both the internal tertiary amines and the surface Pyr groups to form the G5.NHAc-Pyr/Cu(II) complexes. We show that the complexes are able to inhibit the proliferation of different cancer cell lines with half-maximal inhibitory concentrations ranging from 4 to 10μM and induce significant cancer cell apoptosis. Due to the presence of Cu(II), the G5.NHAc-Pyr/Cu(II) complexes display an r1 relaxivity of 0.7024 mM-1 s-1, enabling effective in vivo MR imaging of tumor xenografts and lung metastatic nodules. Further, under radiotherapy (RT) conditions, the tumor MR imaging sensitivity can be significantly enhanced, and the G5.NHAc-Pyr/Cu(II) complexes enable the enhanced chemotherapy of both a xenografted tumor model and a blood-vessel metastasis model. With the demonstrated theranostic potential of the dendrimer-Cu(II) nanocomplexes without addnl. agents or elements for RT-enhanced MR imaging and chemotherapy of tumor and tumor metastasis, this novel Cu(II)-based nanohybrids may hold great promise for the theranostics of different cancer types and metastases. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Product Details of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Product Details of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Feng, Chao; Wuren, Qiqige; Zhang, Xinyu; Sun, Xiaoying; Na, Qin published their research in PLoS One in 2021. The article was titled 《Effects of dietary chromium picolinate supplementation on broiler growth performance: A meta-analysis》.Recommanded Product: Picolinic acid The article contains the following contents:

A meta-anal. was conducted to assess the effects of dietary chromium picolinate (CrPic) supplementation on broiler growth performance and to determine whether such effects are regulated by broiler strains, sex, environmental stress, or contextual factors including study area and years. Eligible studies were identified by searching the Web of Science, Springer, Elsevier, ScienceDirect, Taylor & Francis Online databases. Weighted average differences with corresponding 95% confidence intervals were computed with a random-effects model. We performed subgroup anal. stratified by study area, published years, broiler strains and sex, and environmental stress. Publication bias was assessed with Egger’s test method. A total of 15 studies eligible for inclusion. The results indicated that CrPic supplementation significantly improved broiler growth performance and subgroup anal. confirmed this conclusion. We also found that Ross 308 or male broilers might be more sensitive to CrPic supplementation and showed better growth performance. A model was used to obtain the amount of chromium addition under the optimal growth performance, which suggested that the maximum value of average daily gain (ADG) was reached when chromium addition was 1810μg/kg. The results of the sensitivity anal. showed low sensitivity and high stability of the meta-anal. CrPic supplementation had a pos. effect on the growth performance of broilers, and this meta-anal. provides a more accurate value of chromium addition, which may be beneficial for the practice of the broiler industry. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Animal included an article by Lu, L.; Zhao, L. L.; Dong, S. Y.; Liao, X. D.; Dong, X. Y.; Zhang, L. Y.; Luo, X. G.. Safety of Picolinic acid. The article was titled 《Dietary supplementation of organic or inorganic chromium modulates the immune responses of broilers vaccinated with Avian Influenza virus vaccine》. The information in the text is summarized as follows:

Dietary supplementation with the organic chromium (Cr) has been shown to pos. affect the immune function of poultry. However, to our knowledge, no experiment has been done to directly compare the impacts of Cr chloride and chromium picolinate (CrPic) on the immune responses of broilers vaccinated with Avian Influenza (AI) virus vaccine. Therefore, the present experiment was conducted to investigate the effects of supplemental Cr sources (Cr chloride and CrPic) and levels on the growth performance and immune responses of broilers vaccinated with AI virus vaccine so as to provide an effective nutritional strategy for improving immune function of broilers. A total of 432 1-day (d)-old male broiler chicks were used in a 1 plus 2×4 design. Chickens were given either a diet without Cr supplementation (control) or diets supplemented with 0.4, 0.8, 1.6, or 3.2 mg Cr/kg as either Cr chloride or CrPic for 42 d. Compared to the control, dietary Cr supplementation had no effect (P greater than 0.05) on average daily gain, average daily feed intake and gain : feed of broilers during the starter and grower phases, but increased (P less than 0.05) the relative weights of bursa of fabricius on d 21 and thymus, spleen, or bursa of fabricius on d 42, serum antibody titers against AI virus on d 21, 28, 35 and 42, blood T-lymphocyte transformation rate on d 28 and 42, blood T-lymphocyte percentage on d 42, and serum interleukin-2 contents on d 28. Broilers fed the diets supplemented with the inorganic Cr chloride had higher (P less than 0.05) weights of thymus, spleen and bursa of fabricius than those fed the diets supplemented with the CrPic on d 42. In addition, broilers fed the diets supplemented with the CrPic had higher (P less than 0.05) antibody titers against AI virus than those fed the diets supplemented with the inorganic Cr chloride on d 21 and 35. These results indicate that dietary Cr supplementation improved immune responses of broilers vaccinated with AI virus, and the inorganic Cr chloride was more effective than the CrPic in increasing the relative weights of lymphoid organs, however, the CrPic was more effective than the inorganic Cr chloride in enhancing the serum antibody titer against AI virus. In the experiment, the researchers used many compounds, for example, Picolinic acid(cas: 98-98-6Safety of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Safety of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Letters included an article by Ying, Jun; Fu, Lu-Yang; Zhong, Guoqiang; Wu, Xiao-Feng. Formula: C6H5NO2. The article was titled 《Cobalt-Catalyzed Direct Carbonylative Synthesis of Free (NH)-Benzo[cd]indol-2(1H)-ones from Naphthylamides》. The information in the text is summarized as follows:

A cobalt-catalyzed C-H carbonylation of naphthylamides for the synthesis of benzo[cd]indol-2(1H)-one scaffolds was developed. The reaction employs a traceless directing group and uses benzene-1,3,5-triyl triormate as the CO source, affording various free (NH)-benzo[cd]indol-2(1H)-ones in moderate to high yields (up to 88%). Using this protocol, the total synthesis of BET bromodomain inhibitors A and B was accomplished as well. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6Formula: C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Soldin, Zeljka; Kukovec, Boris-Marko; Matkovic-Calogovic, Dubravka; Popovic, Zora published an article in 2021. The article was titled 《The Solvent Effect on Composition and Dimensionality of Mercury(II) Complexes with Picolinic Acid》, and you may find the article in Molecules.SDS of cas: 98-98-6 The information in the text is summarized as follows:

Three new mercury(II) coordination compounds, {[HgCl(pic)]}n (1), [HgCl(pic)(picH)] (2), and [HgBr(pic)(picH)] (3) (picH = pyridine-2-carboxylic acid, picolinic acid) were prepared by reactions of the corresponding mercury(II) halides and picolinic acid in an aqueous (1) or alc.-methanol or ethanol (2 and 3) solutions Two different types of coordination compounds were obtained depending on the solvent used. The crystal structures were determined by the single-crystal X-ray structural anal. Compound1 is a one-dimensional (1-D) coordination polymer with mercury(II) ions bridged by chelating and bridging N,O,O′-picolinate ions. Each mercury(II) ion is four-coordinated with a bidentate picolinate ion, a carboxylate O atom from the symmetry-related picolinate ion and with a chloride ion; the resulting coordination environment can be described as a highly distorted tetrahedron. Compounds 2 and 3 are isostructural mononuclear coordination compounds, each mercury(II) ion being coordinated with the resp. halide ion, N,O-bidentate picolinate ion, and N,O-bidentate picolinic acid in a highly distorted square-pyramidal coordination environment. Compounds 1-3 were characterized by IR spectroscopy, PXRD, and thermal methods (TGA/DSC) in the solid state and by 1H and 13C NMR spectroscopy in the DMSO solution In the part of experimental materials, we found many familiar compounds, such as Picolinic acid(cas: 98-98-6SDS of cas: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.SDS of cas: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Food Chemistry included an article by Wu, Xiaoming; Wang, Hao; Yang, Shaoxiang; Tian, Hongyu; Liu, Yongguo; Sun, Baoguo. Product Details of 98-98-6. The article was titled 《A novel coumarin-based fluorescent probe for sensitive detection of copper(II) in wine》. The information in the text is summarized as follows:

A novel coumarin-based fluorescent probe (probe 1) for the detection of copper(II) was developed. The fluorescence intensity of probe 1 showed a linear relationship with the concentration of copper(II) in the range 0-16μM (0-1.02 mg/L) and the limit of detection was 62 nM (3.94μg/L). The luminescence of probe 1 at the maximum allowable amounts of copper(II) in wine and water could be observed with the naked eye under a 365-nm UV lamp. Moreover, probe 1 was successfully used for the qual. and quant. detection of copper(II) in wine. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Product Details of 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Product Details of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer》 were Zhao, Zhicong; Shang, Dongsheng; Qiu, Lipeng; Guo, Chang; Li, Yanyan; Liu, Hanqing; Yuan, Guoyue; Tu, Zhigang. And the article was published in Life Sciences in 2019. Synthetic Route of C6H5NO2 The author mentioned the following in the article:

Gastric cancer (GC) is a common cancer with a relatively low survival rate. Cellular senescence, a potent anti-cancer mechanism, is naturally occurred, and can be induced by chemotherapeutic agents. We sought to explore new compounds against GC cells by inducing cellular senescence. Primary screening of a library of N-heterocyclic compounds identified some with potent inhibitory effects on GC cells. Furthermore, in vitro effects of the most potent candidate compound on the proliferation and senescence of GC cells were studied by classical assays, including senescence-associated (SA)-beta-galactosidase staining, and immunofluorescence; and in vivo effects of this compound was evaluated in a xenograft tumor mouse model. Among 43 tested compounds, 4,5-diphenyl-2-Me picolinate (DMP) showed the highest inhibition effects on the growth of GC cells. In vitro experiments showed that DMP inhibited the proliferation by inducing senescence and DNA-damage associated protein markers and signaling pathways. In vivo experiment confirmed that DMP treatment inhibited tumor growth by promoting DNA-damage signaling. This study set up a platform to identify senescence-inducing anti-cancer compounds, and uncovers that DMP exerted anticancer effects by inducing cellular senescence through targeting DNA damage and associated signaling pathways in GC cancer. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Synthetic Route of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Synthetic Route of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A novel, robust method for quantification of multiple kynurenine pathway metabolites in the cerebrospinal fluid》 was written by Schwieler, Lilly; Trepci, Ada; Krzyzanowski, Stanislaw; Hermansson, Sigurd; Granqvist, Mathias; Piehl, Fredrik; Venckunas, Tomas; Brazaitis, Marius; Kamandulis, Sigitas; Lindqvist, Daniel; Jones, Arthur Daniel; Erhardt, Sophie; Brundin, Lena. COA of Formula: C6H5NO2 And the article was included in Bioanalysis in 2020. The article conveys some information:

Kynurenine metabolites are potential modulators of psychiatric disease. We aimed to develop a highly sensitive biochem. anal. of cerebrospinal fluid (CSF) tryptophan (TRP) metabolites, to investigate the stability of metabolites and to confirm our previous findings of aberrant CSF quinolinic acid (QUIN) and picolinic acid (PIC) in suicide attempters using this method. Ten CSF TRP metabolites were analyzed with ultraperformance LC-MS/MS. The method showed small intra- and interassay variation. Metabolites were stable following freeze-thaw cycles. A decreased CSF PIC/QUIN ratio was found in suicide attempters. The feasibility of reliably determining CSF TRP metabolites were demonstrated, including separation of the two isomers PIC and nicotinic acid (NA) and the finding of a reduced PIC/QUIN ratio replicated in suicide attempters. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6COA of Formula: C6H5NO2)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.COA of Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Picolinic acidIn 2020 ,《Tailoring In Situ Healing and Stabilizing Post-Treatment Agent for High-Performance Inverted CsPbI3 Perovskite Solar Cells with Efficiency of 16.67%》 was published in ACS Energy Letters. The article was written by Fu, Sheng; Wan, Li; Zhang, Wenxiao; Li, Xiaodong; Song, Weijie; Fang, Junfeng. The article contains the following contents:

CsPbI3 perovskite solar cells (PSCs) have revealed promising applications for high-performance photovoltaic devices. Despite the high efficiency for regular CsPbI3 PSCs, poor stability for adverse dopants reflects the importance of the inverted. However, the inverted lag far for a phase transition and inferior CsPbI3 films. Here, we report an effective post-treatment agent, methylammonium pyridine-2-carboxylic (MAPyA), to heal and stabilize CsPbI3 films. MAPyA on CsPbI3 can decompose into methylamine (MA) gas and pyridine-2-carboxylate (PyA-) at 100°C, and MA could remove pinholes, while PyA- gifts effective passivation. In addition, oriented PyA- hinders phase transition and isolates external erosions for long-term stability. The optimized devices show the highest efficiency among the inverted CsPbI3 PSCs of 16.67%. Besides, the phase stability and robustness against external erosions get considerable promotion. More importantly, unpackaged I-rich inorganic PSCs are rarely reported with long-term maximum power point in ambient condition, and our unencapsulated device still retains 81.31% of the initial efficiency after 1800 min of outdoor operation (relative humidity 30%).Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Quality Control of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 98-98-6In 2019 ,《Palladium-Catalyzed C8-H Acylation of 1-Naphthylamines with Acyl Chlorides》 appeared in Organic Letters. The author of the article were Yu, Xiaomeng; Yang, Fan; Wu, Yusheng; Wu, Yangjie. The article conveys some information:

A facile and efficient protocol for palladium-catalyzed regioselective C8-H acylation of 1-naphthylamine derivatives with acyl chlorides has been developed. The reaction exhibits broad functional group tolerance, and both aromatic and α,β-unsaturated acyl chlorides can be effectively coupled with 1-naphthylamines. Moreover, the picolinamide moiety as a bidentate directing group likely plays a key role in this regioselective transformation. In the part of experimental materials, we found many familiar compounds, such as Picolinic acid(cas: 98-98-6SDS of cas: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.SDS of cas: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem