Category: 98-98-6

Reference of Picolinic acidIn 2019 ,《Structure and mechanism of piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus》 was published in Acta Crystallographica, Section D: Structural Biology. The article was written by Hasse, Dirk; Hulsemann, Janne; Carlsson, Gunilla H.; Valegaard, Karin; Andersson, Inger. The article contains the following contents:

The core of β-lactam antibiotics originates from amino acids of primary metabolism in certain microorganisms. β-Lactam-producing bacteria, including Streptomyces clavuligerus, synthesize the precursor of the amino acid α-aminoadipic acid by the catabolism of lysine in two steps. The second reaction, the oxidation of piperideine-6-carboxylate (or its open-chain form α-aminoadipate semialdehyde) to α-aminoadipic acid, is catalyzed by the NAD+-dependent enzyme piperideine-6-carboxylate dehydrogenase (P6CDH). This structural study, focused on ligand binding and catalysis, presents structures of P6CDH from S. clavuligerus in its apo form and in complexes with the cofactor NAD+, the product α-aminoadipic acid and a substrate analog, picolinic acid. P6CDH adopts the common aldehyde dehydrogenase fold, consisting of NAD-binding, catalytic and oligomerization domains. The product binds in the oxyanion hole, close to the catalytic residue Cys299. Clear d. is observed for the entire cofactor, including the nicotinamide riboside, in the binary complex. NAD+ binds in an extended conformation with its nicotinamide ring overlapping with the binding site of the carboxylate group of the product, implying that the conformation of the cofactor may change during catalysis. The binding site of the substrate analog overlaps with that of the product, suggesting that the cyclic form of the substrate, piperideine-6-carboxylate, may be accepted as a substrate by the enzyme. The catalytic mechanism and the roles of individual residues are discussed in light of these results. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Reference of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Reference of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Stress associated protein from Lobularia maritima: Heterologous expression, antioxidant and antimicrobial activities with its preservative effect against Listeria monocytogenes inoculated in beef meat》 were Ben Hsouna, Anis; Ben Saad, Rania; Zouari, Nabil; Ben Romdhane, Walid; Brini, Faical; Ben Salah, Riadh. And the article was published in International Journal of Biological Macromolecules in 2019. Formula: C6H5NO2 The author mentioned the following in the article:

Stress associated Protein from Lobularia maritima (LmSAP) transcripts showed up-regulation in response to wounding, Methyl-jasmonate acid, Picolinic acid, and ethephon treatments. The antioxidant activities of the purified LmSAP protein were evaluated using various in vitro and in vivo assays. LmSAP has an excellent DPPH scavenging ability and exhibits notable reducing power capacity and led to a decrease in TBARS values. The LmSAP showed an important antimicrobial activity against different pathogenic strains tested. In fact, the Inhibition Zone (IZ), Minimal Inhibitory Concentration (MIC) and The Min. Bactericidal Concentration (MCB) recorded were in the range of 14-22 mm, 62-250 μg/mL and 125-250 μg/mL, resp. The LmSAP protein successfully inhibited the growth of L. monocytogenes in minced beef meat. Furthermore, the LmSAP enhanced the sensory acceptability extending the shelf life of minced beef meat. Overall, the finding demonstrates that the application of LmSAP may open new promising opportunities for the prevention of bacterial contamination, particularly L. monocytogenes, during minced beef meat storage. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Formula: C6H5NO2) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis of ethyl 4-(4-nitrophenoxy) picolinate》 were Xiong, Hehua; Gao, Yanli; Yang, Qi; Tang, Qidong; Zheng, Pengwu. And the article was published in IOP Conference Series: Materials Science and Engineering in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

Et 4-(4-nitrophenoxy) picolinate 4 is an important intermediate for the synthesis of many biol. active compounds The compound Et 4-(4- nitrophenoxy) picolinate was obtained by three simple steps to synthesis from 2- picoliniacid. In this paper, three novel chloropicolinoyl chloride derivatives were prepared The structure was confirmed by MS and 1H NMR. Furthermore, the synthetic method was optimized. The total yield of the target product was 78.57%. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Category: pyridine-derivatives)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《The conformational analyses of 2-amino-N-[2-(dimethylphenoxy)ethyl]propan-1-ol derivatives in different environments》 was published in Acta Crystallographica, Section C: Structural Chemistry in 2020. These research results belong to Nitek, Wojciech; Kania, Agnieszka; Marona, Henryk; Waszkielewicz, Anna M.; Zeslawska, Ewa. Application of 98-98-6 The article mentions the following:

Four crystal structures of 2-amino-N-(dimethylphenoxyethyl)propan-1-ol derivatives, characterized by X-ray diffraction anal., are reported. The free base (R,S)-2-amino-N-[2-(2,3-dimethylphenoxy)ethyl]propan-1-ol, C13H21NO2, 1, crystallizes in the space group P21/n, with two independent mols. in the asym. unit. The hydrochloride, (S)-N-[2-(2,6-dimethylphenoxy)ethyl]-1-hydroxypropan-2-aminium chloride, C13H21NO2+Cl-, 2c, crystallizes in the space group P21, with one cation and one chloride anion in the asym. unit. The asym. unit of two salts of 2-picolinic acid, namely, (R,S)-N-[2-(2,3-dimethylphenoxy)ethyl]-1-hydroxypropan-2-aminium pyridine-2-carboxylate, C13H22NO2+·C6H4NO2-, 1p, and (R)-N-[2-(2,6-dimethylphenoxy)ethyl]-1-hydroxypropan-2-aminium pyridine-2-carboxylate, C13H22NO2+·C6H4NO2-, 2p, consists of one cation and one 2-picolinate anion. Salt 1p crystallizes in the triclinic centrosym. space group P [inline formula omitted] , while salt 2p crystallizes in the space group P41212. The conformations of the amine fragments are contrasted and that of 2p is found to have an unusual antiperiplanar arrangement about the ether group. The crystal packing of 1 and 2c is dominated by hydrogen-bonded chains, while the structures of the 2-picolinate salts have hydrogen-bonded rings as the major features. In both salts with 2-picolinic acid, the specific R12(5) hydrogen-bonding motif is observed Structural studies have been enriched by the generation of fingerprint plots derived from Hirshfeld surfaces. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Application of 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Al-Sayed, Emir; Tanuhadi, Elias; Giester, Gerald; Rompel, Annette published an article in Acta Crystallographica, Section C: Structural Chemistry. The title of the article was 《Synthesis and characterization of the ′Japanese rice-ball′-shaped Molybdenum Blue Na4-[Mo2O2(OH)4(C6H4NO2)2]2[Mo120Ce6O366H12(OH)2(H2O)76]-200H2O》.Recommanded Product: 98-98-6 The author mentioned the following in the article:

The hybridized lanthanide-containing molybdenum blue (Ln-MB) wheel Na4[Mo2O2(OH)4(C6H4NO2)2]2[Mo120Ce6O366H12(OH)2(H2O)76]∼200H2O ({Mo2(C6H4NO2)2}2{Mo120Ce6}) was assembled in an aqueous one-pot synthesis. The Ln-MB was hybridized with 2-picolinic acid through the generation of the organometallic counter-ion [Mo2O2(OH)4(C6H4NO2)2]2+. Control experiments demonstrated that the position of the carboxylic acid group (2-position to the N atom) in the hybridization component is critical in yielding single crystals of Ln-MB. In addition to single-crystal X-ray diffraction (XRD) anal., which revealed a ′Japanese rice-ball′-shaped Ln-MB as the anion, elemental analyses, IR spectroscopy, and thermogravimetric anal. (TGA) were performed to confirm its structure and composition Bond-valence-sum calculations (BVS) revealed that ({Mo2(C6H4NO2)2}2{Mo120Ce6}) is composed of a 24-electron reduced anionic ring, which was confirmed by Vis-NIR spectroscopy. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Recommanded Product: 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, structure and magnetic property of a tricapped trigonal prismatic TbIII -based 3d-4f complex》 was written by Zhuang, Jia-Jia; Chen, Ming-Guang; Sun, Yan-Bing; Hang, Pei; Sui, Yang; Tong, Jia-Ping. Safety of Picolinic acid And the article was included in IOP Conference Series: Materials Science and Engineering in 2020. The article conveys some information:

A novel 3d-4f CoII/TbIII cluster [Co6Tb(Pic)6O3Cl3](H2O)6 (1) (Pic = 2-Picolinic acid) has been synthesized and characterized via X-ray crystallog. and magnetic measurements. X-ray crystallog. and continued shape measurements anal. revealed that the central Terbium (III) is coordinated in TbO9 geometry with D3h symmetry. Magnetic studies indicated the complex presents a magnetic anisotropy with ferrimagnetic interactions. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Safety of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Safety of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 98-98-6In 2021 ,《Concentration effects on optical properties, DFT, crystal characterization and α-glucosidase activity studies: Novel Zn(II) complex》 appeared in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The author of the article were Dege, Necmi; Ozge, Ozgen; Avci, Davut; Basoglu, Adil; Sonmez, Fatih; Yaman, Mavise; Tamer, Omer; Atalay, Yusuf; Zengin Kurt, Belma. The article conveys some information:

A novel Zn(II) complex of 6-ClpicH and picH was synthesized and its structure was determined by XRD technique. The detailed exptl. optical susceptibility and band gap, refractive index, linear polarizability, optical and elec. conductivity parameters in various concentrations were studied by the UV-visible spectroscopic data. The optical band gap, refractive index (n), linear optical susceptibility (χ(1)), third-order nonlinear optical susceptibility (χ(3)), second- and third-order nonlinear optical (β and γ) parameters were examined by using DFT/M06-L and ωB97XD/6-311++G(d,p) levels. The IC50 value of Zn(II) complex against α-glucosidase was also obtained at 0.44 mM. The exptl. band gap of the Zn(II) complex at 13, 33, 44 and 94μM concentrations in ethanol are 4.38, 4.37, 4.35 and 4.28 eV, resp. The third-order NLO susceptibility χ(3) parameter at 94μM concentration corresponding to the photon energies of 4.6 and 5.7 eV in the UV-visible region were observed at 206.6 x 10-13 and 294.3 x 10-13 esu, resp. Besides, the theor. χ(3) values were obtained at 50.58 x 10-13 and 20.37 x 10-13 esu by using M06-L level. Zn(II) complex could be an effective third-order NLO candidate material. In brief, the detailed theor. and exptl. structural, spectral and optical properties of the Zn(II) complex were presented comparatively. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Related Products of 98-98-6) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Related Products of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Study Protocol for a Randomized Controlled Trial Evaluating the Effectof Chromium Picolinate Supplementation on Gene Expression of TumorNecrosis Factor-α and DNA Damage in Metabolic Syndrome Patients.》 was written by Mozaffari-Khosravi, Hassan; Jambarsan, Sara; Karimpour, Fazad; Hosseini, Seyyed Ebrahim; Kour, Behrooz Ebrahimzadeh. Application In Synthesis of Picolinic acid And the article was included in Saudi journal of kidney diseases and transplantation in 2021. The article conveys some information:

Metabolic syndrome (MS) is caused by environmental factors as well as genetic. Human studies of efficacy of chromium for glucose and lipid metabolism and insulin function is not still definitive. Furthermore, the effect of chromium supplementation on the expression of inflammatory genes in patients with MS has not been studied. We will assess effects of chromium picolinate supplementation on gene expression of tumor necrosis factor-α (TNF-α) and DNA damage in MS patients. In this triple-blind randomized placebo-controlled clinical trial, 48 MS patients will be randomly assigned into two groups to receive daily 400 μg chromium picolinate supplement or placebo for 12 weeks. The outcome measures include of change in fasting blood sugar, glycosylated hemoglobin A1C, inflammatory biomarkers, lipid profile, blood pressure, gene expression of TNF-α, and 8-hydroxy-deoxyguanosine concentration as DNA damage biomarker, will be quantified at baseline and end of intervention. This protocol was approved by Institutional Research Ethics Committee School of Public Health Shahid Sadoughi University of Medical Sciences (Approval ID: IR.SSU.SPH.REC.1399.141). In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Zheng; Xu, Yanqi; Xu, Huandi; Cui, Mengyuan; Liu, Tianguang; Ren, Xiangyu; Sun, Jianfei; Deng, Dawei; Gu, Yueqing; Wang, Peng published their research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2021. The article was titled 《A dicyanomethylene-4H-pyran-based fluorescence probe with high selectivity and sensitivity for detecting copper (II) and its bioimaging in living cells and tissue》.Computed Properties of C6H5NO2 The article contains the following contents:

Copper (Cu) plays a significant role in the process of oxygenic photosynthesis in living systems. The detection of copper ion (Cu2+) is valuable and meaningful for further studying the functions of Cu2+ under physiol. and pathol. conditions. A novel fluorescence probe DCM-Cu (I) based on the near-IR (NIR) fluorophore dicyanomethylene-4H-pyran (DCM) was designed for Cu2+ detection. The probe DCM-Cu possessed characteristic of “”turn-on”” fluorescent signal in the presence of Cu2+ through the enhanced ICT process. It exhibited satisfactory sensitivity and selectivity toward Cu2+. A good linear correlation was observed between the concentrations of Cu2+ and the fluorescence intensities at 700 nm. The detection limit (LOD) of DCM-Cu toward Cu2+ is 2.54 × 10-8 M. Importantly, DCM-Cu was successfully applied in the detection of Cu2+ in living MCF-7 cells and tumor tissue with low cytotoxicity. Therefore, this probe would have the potential to monitor cellular Cu2+ in the living system and be applied to the diagnosis of related diseases. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chromogenic hydrazide Schiff base reagent: Spectrophotometric determination of CN- ion》 was published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020. These research results belong to Dey, Sunanda; Sen, Chandana; Sinha, Chittaranjan. Name: Picolinic acid The article mentions the following:

A Schiff base reagent, Picolinohydrazide-naphthol (HL), was used for trace level detection of toxic CN- selectively in presence of eighteen other anions (SCN-, OCN-, S2O2-3, HPO2-4, H2PO-4, I-, ClO-4, HSO-4, SO2-4, AsO3-4, NO-2, AsO-2, Cl-, F-, HF-2, NO-3, Br-, N-3) by visual color change, colorless to yellow, in DMSO/H2O (9:1, volume/volume) at pH, 7.2 (HEPES buffer) medium. The sensitivity of the probe shows that the limit of detection (LOD) is 7.08μM. The probable mechanism for the sensing behavior involves the deprotonation of naphthol-OH by CN- that was authenticated by 1H NMR titration and Mass spectra. The composition (1:1 mol ratio) is supported by Job’s plot and binding constant (Ka, 1.5 × 104 M-1) is reported by Benesi-Hildebrand plot. Also, a simple paper strip device is fabricated for the determination of CN- ion in water. DFT computation is carried out to explain the electronic spectral feature of the sensor.Picolinic acid(cas: 98-98-6Name: Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Name: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem