Category: 98-98-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-98-6, name is Picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Picolinic acid

General procedure: A mixture of o-phenylendiamine (1 eq) and the corresponding picolinic acid (1 eq), and 5-20 eq of polyphosphoric acid was stirred in an oil bath at 170 C for 4 h. The mixture was cooled to 100 C and then poured into rapidly stirred water. The pH was adjusted to 7 with NaHCO3. The solid was collected by filtration, and recrystallized from EtOAc to afford the corresponding products with 60-80% yields.

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Reference:
Article; Jia, Jianhuan; Jiang, Chenglin; Zhang, Xiaojing; Jiang, Yongwen; Ma, Dawei; Tetrahedron Letters; vol. 52; 43; (2011); p. 5593 – 5595;,
Pyridine – Wikipedia,
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Reference of 98-98-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 98-98-6, name is Picolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

To 150 g of thionyl chloride, 38 g of a mixture of 2-pyridinecarboxylic acid hydrochloride and methyl 2-pyridinecarboxylate hydrochloride and 3 g of sodium bromide were added,Slowly warmed to reflux and then maintained at reflux for 16 h. After cooling down to 40 C, 200 g of toluene was added, the thionyl chloride was distilled off under reduced pressure, the temperature was lowered to 10 C, and 50 g of methanol was added dropwise and refluxed for 2 h. And then cooled to 0 C. The filtrate was washed with toluene and suspended in 10 C water. Sodium carbonate was added to precipitate a pale yellow solid. The solid was filtered off, recrystallized from water and dried at room temperature for 18 hours to obtain 25 g of white needle crystals.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 98-98-6, Picolinic acid.

Reference:
Patent; Jinan Chenghui Shuangda Chemical Co., Ltd; Liu, Hao; Meng, de Yong; Wang, Yin; Li, Yuedong; Zhao, hui Qing; (5 pag.)CN105218436; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 98-98-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 98-98-6, name is Picolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

1) Synthesis of (4-Chloropvridine-2-carboxylic acid)-methvlamide (2) ci I 1. SOC12 CH NH DMF MgClz _ O THF O 2. MeOH N N Toluene 1 60 ml of thionylchloride are heated to 45 C under a N2 atmosphere, and slowly mixed with 1.83 ml dimethyl formamide. To this solution, 20 g of pyridine-2-carboxylic acid are added portion wise. The reaction mixture is stirred for another 15 min at 45 C and subsequently kept at 80 C for 24 hours. The reaction mixture is evaporated to dryness, the residue is stripped several times with water free toluene. The oil obtained by this procedure is dissolved in toluene, chilled to 0 C, slowly mixed with methanol and stirred for 1 hour. The precipitated solid is separated by suction filtration, washed with toluene and recrystallized from acetone. Yield : 15 g (44 %) of 1, colorless crystals

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 98-98-6, Picolinic acid.

Reference:
Patent; MERCK PATENT GMBH; WO2005/58832; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-98-6, name is Picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H5NO2

General procedure: A diamine compound (0.05 mol) was mixed with a dicarboxylicacid or an acid anhydride (0.025 mol) and the mixture was poured into 50 ml of preheated (100C) polyphosphoric acid. The mixture was stirred and heated at 175C for 3-5 h. The reaction mixture was then poured in ice cold water and allowed to stand overnight.The precipitate was removed by filtration and washed several times with diluted sodium hydrogen carbonate solution and finally with water. The reaction product was then air dried and weighed.The products were characterized with NMR and mass spectroscopy (Table 4) and representative examples were characterized with elemental analysis (Table 3).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 98-98-6, Picolinic acid.

Reference:
Article; Elagab, Hamdi Ali; Alt, Helmut G.; Inorganica Chimica Acta; vol. 431; (2015); p. 266 – 275;,
Pyridine – Wikipedia,
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Synthetic Route of 98-98-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 98-98-6, name is Picolinic acid. A new synthetic method of this compound is introduced below.

Description 1; 3-Iodo-2-pyridinecarboxylic acid (D1); To a stirred solution of 2,2,6,6-tetramethylpiperidine (20 ml, 0.122 mol) in dry THF (100 ml) at -78¡ã C., under argon was added n-butyllithium (52 ml, 0.163 mol, 2.5M solution in hexanes) dropwise, followed 15 min later by a solution of 2-pyridinecarboxylic acid (5.0 g, 0.0407 mol) in dry THF (30 ml). After 10 min at -78¡ã C., the reaction mixture was warmed to 0¡ã C. for 30 min. and then transferred to a solution of iodine (30.9 g, 0.243 mol) in dry THF (70 ml) at 0¡ã C., under argon. After 15 min at 0¡ã C. the reaction mixture was warmed to 25¡ã C. and stirred for 1 h. After this period water (80 ml) was added and the reaction mixture concentrated in vacuo. The residue was re-dissolved in water (100 ml) and washed with EtOAc (100 ml). The aqueous layer was separated, concentrated in vacuo and the resulting residue triturated with diethyl ether. The solid material was filtered and dried in vacuo before being re-dissolved in MeOH (200 ml). To this solution was added Amberlyte IR-120 ion-exchange resin (100 g) and the reaction mixture stirred at 25¡ã C. for 2 h. After this period the resin was filtered off and the solvents concentrated in vacuo to afford the title compound (4.15 g, 41percent). deltaH (DMSO-d6, 250 MHz) 6.79 (1H, bs) 7.28 (1H, dd), 8.37 (1H, dd), 8.58 (1H, dd). MS (ES): C6H41NO2 requires 249. found (M-H+) 248.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98-98-6, its application will become more common.

Reference:
Patent; Glaxo Group Limited; US2008/312209; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

98-98-6 , The common heterocyclic compound, 98-98-6, name is Picolinic acid, molecular formula is C6H5NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Picolinic acid (20.0 mmol) and 1,2-diaminobenzene (20.0 mmol) were added to 28 g PPA (polyphosphric acid),and stirred at 160 C for 8 h. The resulting viscous solution was poured into 500 mL water, producing a solid which was collected by suction filtration. The solid was suspended in 500 mL of aqueous 0.5 M Na2CO3, and filtered giving a pale yellow powder. Recrystallization from methanol/water. Yield: 43%, m.p.: 219 C, chemical formula (mol.wt.): C12H9N3 (195.22 g/mol), elemental analysis, calc. (%): C, 73.83; H, 4.65; N, 21.52, found: C, 73.75; H, 4.54; N, 21.43, 1H NMR: 8.213 (d, 2H, H4′,5′ ), 8.169 (d, 1H, H6” ), 7.964 (dt, 1H, H4” ), 7.737 (d, 1H, H3” ), 7.699-7.592 (complex, 4H, H 3′,6′,1,5” ), 13C NMR: 159.36 (C2” ), 156.91 (C2), 146.76 (C6” ), 137.35 (C2′ ), 133.22 (C1′ ), 130.54 (C4” ), 129.50 (C5′ ), 129.09 (C4′ ), 128.55 (C3” ), 128.30 (C3′), 127.41 (C6′ ), 117.44 (C5” ), FT-IR (KBr, cm-1): nu(NH), 3399 (s); nu(C-H), 3055 (m); nu(C=C), 1545 (s); nu(C=N), 1532 (s); delta(C-H), 741 (s).

According to the analysis of related databases, 98-98-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Patel, Mohan N.; Dosi, Promise A.; Bhatt, Bhupesh S.; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 86; (2012); p. 508 – 514;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 98-98-6, name is Picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. 98-98-6

[00091] 4-Chloropicolinic acid methyl ester (CYD-1-1). A mixture of picolinic acid (10.0 g, 81.0 mmol, 1 equiv.) and sodium bromide (16.7 g, 162.0 mmol, 2 equiv.) in thionyl chloride (41 mL) was refluxed for 5 h at 80C. After that, the solvent was removed under the vacuum at 85C to afford the brown residue. 80 mL of anhydrous methanol was slowly added into the residue and the mixture was stirred at room temperature for half an hour. The solvent was evaporated, and the residue was taken up in the saturated sodium bicarbonate and extracted with ethyl acetate (three times). The organic layers were combined, washed with saturated brine, dried over anhydrous Na2S04 and evaporated. The residue was purified by silica gel column; eluting with 33% EtOAc in hexane afforded 4-chloropicolinic acid methyl ester (CYD-1-1) (8.0 g, 64%) as a brown solid; silica gel TLC Rf = 0.15 (1 :3 EtOAc/hexane); mp 55-56C; 1H NMR (600 MHz, CDC13) delta 8.67 (d, 1H, J = 4.8 Hz), 8.16 (d, 1H, J = 1.8 Hz), 7.51 (m, 1H), 4.04 (s, 3H).

Statistics shows that 98-98-6 is playing an increasingly important role. we look forward to future research findings about Picolinic acid.

Reference:
Patent; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHOU, Jia; DING, Chunyong; CUNNINGHAM, Kathryn, A.; WO2013/86266; (2013); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

98-98-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98-98-6, name is Picolinic acid, molecular formula is C6H5NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5. Methyl 4-chloropicolinate; A mixture of picolinic acid (15 g, 122 mmol) sodium bromide (1.88 g, 18.3 mmol), and thionyl chloride (45 mL) is heated to reflux and stirred for 20 h. After cooling to rt, the excess thionyl chloride is removed in vacuo. The resulting residue is taken up in toluene (100 mL) and cooled to 0 0C. MeOH (7 mL) is added dropwise, after which time the reaction is warmed to rt and stirred an additional 1.5 h. The precipitated solid is collected by filtration, washed with toluene, and partitioned between EtOAc (200 mL) and water (100 mL). The mixture is neutralized to pH=7-8 with solid NaHCO3. The EtOAc layer is dried (Na2SO4), filtered, and evaporated in vacuo to give the title compound as a light brown solid. MS: 171.94 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 98-98-6, Picolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROGEN CORPORATION; WO2008/70014; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding some certain compound to certain chemical reactions, such as: 98-98-6, name is Picolinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98-98-6. 98-98-6

Example 1Preparation of (R)-4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-(1-(hydroxyamino)-1-oxopropan-2-yl)picolinamide (Compound 1)Step 1a. Methyl 4-chloropicolinate (Compound 102); Anhydrous DMF (10 mL) was slowly added to SOCl2 (300 mL) at 40-48 C. The solution was stirred at room temperature for 10 minutes, and then compound 101 (100.0 g, 813.0 mmol) was added over 30 minutes. The resulting solution was heated at 72 C. (Vigorous SO2 evolution) for 16 h to generate a yellow solid. The resting mixture was cooled to room temperature, diluted with toluene (500 mL) and concentrated to 200 mL. The toluene addition/concentration process was repeated twice. The resulting solution and solid was added into 200 mL methanol at ice bath to keep the internal temperature below 55 C. The content were stirred at r.t. for 45 min, cooled to 5 C. and treated with Et2O (200 mL) dropwise. The resulting solid were filtered, washed with Et2O (200 mL) and dried under 35 C. to provide a white yellow solid. After the solid were solvated to hot water (500 mL, about 45 C.), NaHCO3 was added to adjust pH to 8-9. The mixture was extracted with ethyl acetate and the organic phase was concentrated to give desired compound 102 as a off-white solid (118.2 g, 85%). LCMS: 172 [M+1]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 98-98-6.

Reference:
Patent; Cai, Xiong; Qian, Changgeng; Gould, Stephen; Zhai, Haixiao; US2008/234332; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem