Category: 98-98-6

Yilmaz, Cemile; Gokmen, Vural published an article in 2021. The article was titled 《Formation of amino acid derivatives in white and red wines during fermentation: Effects of non-Saccharomyces yeasts and Oenococcus oeni》, and you may find the article in Food Chemistry.Application In Synthesis of Picolinic acid The information in the text is summarized as follows:

This study aimed to investigate the effect of com. non-Saccharomyces yeasts and Oenococcus oeni on the formation of amino acid derivatives, some of which have neuroactive properties, during fermentation in laboratory-scale processing of white and red wines. Changes in the content of amino acid derivatives during fermentation of large-scale white and red wines were also evaluated. The highest kynurenic, picolinic, and quinolinic acid concentrations were observed in white wine fermented with Torulaspora delbrueckii, Kluyveromyces thermotolerans and Saccharomyces cerevisiae simultaneously. No changes in the content of picolinic and kynurenic acid were observed during large-scale white wine fermentation Tryptophan Et ester concentration in all wines increased significantly during alc. fermentation Natural and O. oeni malolactic fermentation did not alter the content of picolinic acid, a neuroprotective compound, in red wine. The decrease in the content of tyramine, phenylethylamine, and dopamine in laboratory-scale white wines was observed during alc. fermentation The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Organic-inorganic hybrid 1-D double chain heteropolymolybdates constructed from plenary Keggin germanomolybdate anions and hepta-nuclear Cu-RE-pic heterometallic clusters》 were Hu, Huifen; Gong, Peijun; Pang, Jingjing; Jiang, Jun; Chen, Lijuan; Zhao, Junwei. And the article was published in Dalton Transactions in 2019. Application of 98-98-6 The author mentioned the following in the article:

Two unprecedented organic-inorganic hybrid 1-D double chain germanomolybdates containing hepta-nuclear Cu-RE-pic heterometallic clusters [NH4]2[RE(H2O)5]2[Cu(pic)2]2[Cu(pic)2(H2O)2]3[α-GeMo12O40]2·22H2O [RE = La3+ (1), Ce3+ (2), and Hpic = 2-picolinic acid] were successfully obtained by the stepwise self-assembly strategy via the conventional solution method. The most striking structural feature of 1 and 2 is that the two plenary Keggin [α-GeMo12O40]4- polyoxoanions are joined by an organic-inorganic hybrid hepta-nuclear Cu-RE-pic {[RE(H2O)5]2[Cu(pic)2(H2O)2]3[Cu(pic)2]2}6+ heterometallic moiety. What is more interesting is that their adjacent structural units are connected together by {Cu(pic)2} bridges, forming a 1-D extended double chain architecture. Furthermore, the adsorption capacity of 1 toward dyes in aqueous solutions was deeply investigated. It is fascinating that 1 shows a good adsorption capacity toward basic violet 3 (BV 3) in aqueous solutions and the adsorption kinetics conforms to the second-order kinetic model. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Application of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Organic-inorganic hybrids assembled from plenary Keggin-type germanotungstate units and 3d-4f heterometal clusters》 were Li, Huijie; Gong, Peijun; Jiang, Jun; Li, Yamin; Pang, Jingjing; Chen, Lijuan; Zhao, Junwei. And the article was published in Dalton Transactions in 2019. Application of 98-98-6 The author mentioned the following in the article:

Two kinds of organic-inorganic 3d-4f heterometal hybrids based on plenary α-Keggin-type germanotungstates [Cu2(H2O)3(PA)3] [Ln0.5Na0.5Cu2(H2O)12(PA)3][α-GeW12O40]·5H2O [Ln = La3+ (1), Ce3+ (2)] and [Cu2(H2O)2(PA)3][Cu(PA)2][Ln(H2O)7][α-GeW12O40]·7H2O [Ln = Tb3+ (3), Dy3+ (4), HPA = 2-picolinic acid] were prepared via the strategy of combining an in situ assembly reaction and stepwise synthesis in the aqueous solution The most remarkable structural characteristic of 1-2 is that neighboring structural units are connected into a 1-D chain alignment by the bridging di-copper [Cu2(H2O)3(PA)3]+ subunits, whereas the most outstanding structural feature of 3-4 is that neighboring structural units are interconnected to generate a zigzag 1-D chain alignment by the bimetallic bridging [Cu2(H2O)3(PA)3]+ subunits, and then adjacent zigzag 1-D chains are integrated into a fascinating 2-D sheet structure by heterobimetallic bridging {Tb(H2O)7[Cu(PA)2]0.5}3+ subunits and [Cu(PA)2] groups. As far as authors know, 1-4 represent the first examples of plenary Keggin heterometal germanotungstates including organic 3d-4f heterometal subunits so far. The electrochem. sensing properties towards the detection of Acetaminophen of 1/3@CMWCNT-Nafion/GCE electrochem. sensors were investigated, showing that 1/3@CMWCNT-Nafion/GCE electrochem. sensors exhibit good stability and good sensing performance towards AC detection. In the part of experimental materials, we found many familiar compounds, such as Picolinic acid(cas: 98-98-6Application of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Infrared Spectroscopic Detection of Biosignatures at Lake Tirez, Spain: Implications for Marsã€?was published in Astrobiology in 2020. These research results belong to Preston, Louisa J.; Barcenilla, Rebeca; Dartnell, Lewis R.; Kucukkilic-Stephens, Ezgi; Olsson-Francis, Karen. Computed Properties of C6H5NO2 The article mentions the following:

The detection of potential biosignatures with mineral matrixes is part of a multifaceted approach in the search for life on other planetary bodies. The 2020 ExoMars Rosalind Franklin rover includes within its payload three IR spectrometers in the form of ISEM (IR Spectrometer for ExoMars), MicrOmega, and Ma-MISS (Mars Multispectral Imager for Subsurface Studies). The use of this technique in the detection and characterization of biosignatures is of great value. Organic materials are often co-deposited in terrestrial evaporites and as such have been proposed as relevant analogs in the search for life on Mars. This study focuses on Ca-sulfates collected from the hypersaline Tirez Lake in Spain. Mid IR and visible near IR anal. of soils, salt crusts, and crystals with green and red layering indicative of microbial colonization of the samples was acquired from across the lake and identified the main mineral to be gypsum with inputs of carbonate and silica. Organic functional groups that could be attributed to amides and carboxylic acids were identified as well as chlorophyll; however, due to the strong mineralogical absorptions observed, these were hard to unambiguously discern. Taxonomical assignment demonstrated that the archaeal community within the samples was dominated by the halophilic extremophile Halobacteriaceae while the bacterial community was dominated by the class Nocardiaceae. The results of this research highlight that sulfates on Mars are a mixed blessing, acting as an effective host for organic matter preservation but also a material that masks the presence of organic functional groups when analyzed with spectroscopic tools similar to those due to fly on the 2020 ExoMars rover. A suite of complementary anal. techniques therefore should be used to support the spectral identification of any candidate extraterrestrial biosignatures. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Biochemistry included an article by McLeod, Matthew J.; Krismanich, Anthony P.; Assoud, Abdeljalil; Dmitrienko, Gary I.; Holyoak, Todd. Computed Properties of C6H5NO2. The article was titled 《Characterization of 3-[(Carboxymethyl)thio]picolinic Acid: A Novel Inhibitor of Phosphoenolpyruvate Carboxykinaseã€? The information in the text is summarized as follows:

Phosphoenolpyruvate carboxykinase (PEPCK) has traditionally been characterized for its role in the first committed step of gluconeogenesis. The current understanding of PEPCK’s metabolic role has recently expanded to include it serving as a general mediator of tricarboxylic acid cycle flux. Selective inhibition of PEPCK in vivo and in vitro has been achieved with 3-mercaptopicolinic acid (MPA) (Ki âˆ?8μM), whose mechanism of inhibition has been elucidated only recently. On the basis of crystallog. and mechanistic data of various inhibitors of PEPCK, MPA was used as the initial chem. scaffold to create a potentially more selective inhibitor, 3-[(carboxymethyl)thio]picolinic acid (CMP), which has been characterized both structurally and kinetically here. These data demonstrate that CMP acts as a competitive inhibitor at the OAA/PEP binding site, with its picolinic acid moiety coordinating directly with the M1 metal in the active site (Ki âˆ?29-55μM). The extended carboxy tail occupies a secondary binding cleft that was previously shown could be occupied by sulfoacetate (Ki âˆ?82μM) and for the first time demonstrates the simultaneous occupation of both OAA/PEP subsites by a single mol. structure. By occupying both the OAA/PEP binding subsites simultaneously, CMP and similar mols. can potentially be used as a starting point for the creation of addnl. selective inhibitors of PEPCK. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anekthanakul, Krittima; Manocheewa, Siriphan; Chienwichai, Kittiphan; Poungsombat, Patcha; Limjiasahapong, Suphitcha; Wanichthanarak, Kwanjeera; Jariyasopit, Narumol; Mathema, Vivek Bhakta; Kuhakarn, Chutima; Reutrakul, Vichai; Phetcharaburanin, Jutarop; Panya, Atikorn; Phonsatta, Natthaporn; Visessanguan, Wonnop; Pomyen, Yotsawat; Sirivatanauksorn, Yongyut; Worawichawong, Suchin; Sathirapongsasuti, Nuankanya; Kitiyakara, Chagriya; Khoomrung, Sakda published an article in 2021. The article was titled 《Predicting lupus membranous nephritis using reduced picolinic acid to tryptophan ratio as a urinary biomarkerã€? and you may find the article in iScience.Application In Synthesis of Picolinic acid The information in the text is summarized as follows:

The current gold standard for classifying lupus nephritis (LN) progression is a renal biopsy, which is an invasive procedure. Undergoing a series of biopsies for monitoring disease progression and treatments is unlikely suitable for patients with LN. Thus, there is an urgent need for non-invasive alternative biomarkers that can facilitate LN class diagnosis. Such biomarkers will be very useful in guiding intervention strategies to mitigate or treat patients with LN. Urine samples were collected from two independent cohorts. Patients with LN were classified into proliferative (class III/IV) and membranous (class V) by kidney histopathol. Metabolomics was performed to identify potential metabolites, which could be specific for the classification of membranous LN. The ratio of picolinic acid (Pic) to tryptophan (Trp) ([Pic/Trp] ratio) was found to be a promising candidate for LN diagnostic and membranous classification. It has high potential as an alternative biomarker for the non-invasive diagnosis of LN. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Joshi, Arti; Gupta, Ruby; Sharma, Deepika; Singh, Monika published an article in 2021. The article was titled 《A Mo(VI) based coordination polymer as an antiproliferative agent against cancer cellsã€? and you may find the article in Dalton Transactions.Recommanded Product: Picolinic acid The information in the text is summarized as follows:

Metal ions being an important part of biol. systems are of great interest in the designing of new drugs. Molybdenum is an essential trace element for humans, animals, and plants and naturally present in many enzymes hence its complexes can be expected to serve as potential candidates for biomedical applications. A novel molybdenum-based coordination polymer, [Mo2(μ2-O)O4(2-pyc)2(H2O)], is synthesized by a hydrothermal route and structurally characterized by using single crystal X-Ray diffraction. The structure consists of molybdenum octahedra connected by a bridging oxo ligand and 2-pyc forming a one-dimensional coordination polymer. This Mo coordination polymer was found to show a considerable inhibitory effect with IC50 values of 22.63 μmol L-1, 28.19 μmol L-1, and 20.97 μmol L-1, against HepG2 (human liver cancer), A549 (human lung cancer), and MCF-7 (human breast cancer) cell lines resp. This is the first attempt at exploring the molybdenum-based coordination polymer for antitumor applications. The cell cytotoxicity anal. revealed that the anti-tumor potential of the compound is governed by arresting of the A549, HepG2, and MCF-7 cancer cells in the S phase of the cell cycle. UV-Visible absorption spectroscopy further revealed the binding interaction between the Mo coordination polymer and ctDNA and the binding constant was found to be 5.9 x 103 L mol-1, which is in agreement with those of well-known groove binders. This binding interaction in turn induces apoptosis and necrosis pathways leading to the death of the cancer cells.Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: Picolinic acidIn 2020 ,《Characterization of a Mixed-Valence Ru(II)/Ru(III) Ion-Pair Complex. Unexpected High-Frequency Electron Paramagnetic Resonance Evidence for Ru(III)-Ru(III) Dimer Coupling》 was published in Inorganic Chemistry. The article was written by Impert, Olga; Kozakiewicz, Anna; Wrzeszcz, Grzegorz; Katafias, Anna; Bienko, Alina; van Eldik, Rudi; Ozarowski, Andrew. The article contains the following contents:

In this contribution, we report the synthesis and full characterization of the first mixed-valence Ru(II)/Ru(III) ion-pair complex, [RuII(bipy)2(pic)]+[cis-RuIIICl2(pic)2]-, in the solid state and in aqueous solution, where bipy = 2,2′-bipyridine and pic- = picolinate. In addition, unexpected high-frequency ESR evidence for interactions between two neighboring Ru(III) ions, resulting in a triplet state, S = 1, was found.Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Mohr, Alex E.; Jasbi, Paniz; Vander Wyst, Kiley B.; van Woerden, Irene; Shi, Xiaojian; Gu, Haiwei; Whisner, Corrie M.; Bruening, Meg published an article in Scientific Reports. The title of the article was 《Association of food insecurity on gut microbiome and metabolome profiles in a diverse college-based sample》.Electric Literature of C6H5NO2 The author mentioned the following in the article:

Voluntary caloric restriction (e.g., eating disorders) often results in alterations in the gut microbiota composition and function. However, these findings may not translate to food insecurity, where an individual experiences inconsistent access to healthy food options. In this study we compared the fecal microbiome and metabolome of racially and ethnically diverse first year college students (n = 60) experiencing different levels of food access. Students were dichotomized into food secure (FS) and food insecure (FI) groups using a validated, 2-question screener assessing food security status over the previous 30 days. Fecal samples were collected up to 5 days post survey-completion. Gut microbiome and metabolome were established using 16S rRNA amplicon sequencing, targeted liquid chromatog.-tandem mass spectrometry, and gas chromatog.-mass spectrometry. FI students experienced significantly greater microbial diversity with increased abundance of Enterobacteriaceae and Eisenbergiella, while FS students had greater abundance of Megasphaera and Holdemanella. Metabolites related to energy transfer and gut-brain-axis communication (picolinic acid, phosphocreatine, 2-pyrrolidinone) were elevated in FI students (q < 0.05). These findings suggest that food insecurity is associated with differential gut microbial and metabolite composition for which the future implications are unknown. Further work is needed to elucidate the longitudinal metabolic effects of food insecurity and how gut microbes influence metabolic outcomes. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Electric Literature of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Electric Literature of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chlorinated yellow phosphorescent cyclometalated neutral iridophosphors featuring broad emission bandwidths for white electroluminescence》 was written by Tao, Peng; Zheng, Xiao-Kang; Wei, Xiao-Zhen; Lau, Mei-Tung; Lee, Yuk-Ki; Li, Zi-Kang; Guo, Ze-Ling; Zhao, Fang-Qing; Liu, Xing; Liu, Shu-Juan; Zhao, Qiang; Miao, Yan-Qin; Wong, Wai-Yeung. Recommanded Product: 98-98-6This research focused onyellow phosphorescent cyclometalated neutral iridophosphor electroluminescence broad emission bandwidth. The article conveys some information:

The efficient yellow phosphors with broad emission bandwidths play quite important roles in the realization of high-performance two-color white organic light-emitting devices (OLEDs). Herein, by using a chlorine-functionalization method, we designed three efficient yellow iridium(III) complexes (Ir1-Ir3) bearing chlorine atoms. At room temperature, these phosphors exhibit bright yellow phosphorescence with emission wavelengths of 549-574 nm and high photoluminescence efficiency of 0.49-0.73 in the N2-saturated dichloromethane. Importantly, these complexes feature extremely broad emission bandwidths (reaching 104 nm), making them the record-high values in the yellow iridium(III) phosphors reported so far. Using these complexes as the triplet dopants, the prepared OLEDs show yellow phosphorescence with the emission maximum at 565, 548, and 551 nm, resp. The extremely high external quantum efficiency of 23.8% was realized for the as-prepared yellow OLEDs. Furthermore, Ir2-based two-color white OLED with high spectral quality was also realized, and the color rendering index and CIE coordinates for two-color white OLED are 74 and (0.32, 0.34), resp. The broad yellow emission band and high-efficiency of the device proved that these phosphors show great potentials in developing high-performance yellow and white electroluminescence.Picolinic acid(cas: 98-98-6Recommanded Product: 98-98-6) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem