Stonelake, Thomas M.’s team published research in Inorganic Chemistry in 2020 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.HPLC of Formula: 98-98-6

HPLC of Formula: 98-98-6In 2020 ,《Spectroscopic and Theoretical Investigation of Color Tuning in Deep-Red Luminescent Iridium(III) Complexes》 was published in Inorganic Chemistry. The article was written by Stonelake, Thomas M.; Phillips, Kaitlin A.; Otaif, Haleema Y.; Edwardson, Zachary C.; Horton, Peter N.; Coles, Simon J.; Beames, Joseph M.; Pope, Simon J. A.. The article contains the following contents:

A series of heteroleptic, neutral iridium(III) complexes of the form [Ir(L)2(N^O)] (where L = cyclometalated 2,3-disubstituted quinoxaline and N^O = ancillary picolinate or pyrazinoate) are described in terms of their synthesis and spectroscopic properties, with supporting computational analyses providing addnl. insight into the electronic properties. The 10 [Ir(L)2(N^O)] complexes were characterized using a range of anal. techniques (including 1H, 13C, and 19F NMR and IR spectroscopies and mass spectrometry). One of the examples was structurally characterized using X-ray diffraction. The redox properties were determined using cyclic voltammetry, and the electronic properties were investigated using UV-vis, time-resolved luminescence, and transient absorption spectroscopies. The complexes are phosphorescent in the red region of the visible spectrum (λem = 633-680 nm), with lifetimes typically of hundreds of nanoseconds and quantum yields ca. 5% in aerated chloroform. A combination of spectroscopic and computational analyses suggests that the long-wavelength absorption and emission properties of these complexes are strongly characterized by a combination of spin-forbidden metal-to-ligand charge-transfer and quinoxaline-centered transitions. The emission wavelength in these complexes can thus be controlled in two ways: first, substitution of the cyclometalating quinoxaline ligand can perturb both the HOMO and LUMO levels (Cl atoms on the ligand induce the largest bathochromic shift), and second, the choice of the ancillary ligand can influence the HOMO energy (pyrazinoate stabilizes the HOMO, inducing hypsochromic shifts). Heteroleptic neutral iridium(III) complexes [Ir(L)2(N^O)] (where N^O = picolinate or pyrazinoate) that incorporate cyclometalated quinoxaline ligands demonstrate tunable emission in the red region of the visible spectrum. In the experiment, the researchers used Picolinic acid(cas: 98-98-6HPLC of Formula: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.HPLC of Formula: 98-98-6

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Pyridine – Wikipedia,
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Al Saedi, Ahmed’s team published research in Experimental Gerontology in 2020 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Name: Picolinic acid

Name: Picolinic acidIn 2020 ,《The multiple faces of tryptophan in bone biology》 appeared in Experimental Gerontology. The author of the article were Al Saedi, Ahmed; Sharma, Shilpa; Summers, Matthew A.; Nurgali, Kulmira; Duque, Gustavo. The article conveys some information:

A review. Osteoporosis is highly prevalent in older persons. While many advances have been made in the field of osteoporosis, current treatments have been affected by unexpected side effects and limited efficacy; therefore, new approaches to identify disease mechanisms and pathways are required. This review focuses on the influence of tryptophan metabolites, particularly kynurenines and serotonin on bone. The kynurenine (KYN) pathway is associated with osteoblastogenesis and can be linked to the pathophysiol. of osteoporosis. The activity of osteoblasts is reduced by 3-hydroxykynurenine (3-HKYN), a product of KYN. In addition, decreasing concentrations of 3-hydroxyanthranilic acid with aging can be one of the causes of bone loss. In contrast, picolinic acid, an end-product of the KYN pathway, acts as a bone anabolic. On the other hand, gut-derived serotonin (GDS) inhibits bone formation, whereas brain-derived serotonin enhances bone formation and decreases bone resorption. Overall, understanding the exact mechanisms of action of tryptophan metabolites on bone could have great potential to develop effective treatments for osteoporosis and other bone diseases. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Name: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Name: Picolinic acid

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Pyridine – Wikipedia,
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Sonkar, Chanchal’s team published research in RSC Medicinal Chemistry in 2022 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Related Products of 98-98-6

Related Products of 98-98-6In 2022 ,《Ruthenium(II)-arene complexes as anti-metastatic agents, and related techniques》 appeared in RSC Medicinal Chemistry. The author of the article were Sonkar, Chanchal; Sarkar, Sayantan; Mukhopadhyay, Suman. The article conveys some information:

A review. With the discovery of cisplatin, a vast area of applications of metallodrugs in cancer treatment was opened but due to the side effects caused by the cisplatin complexes, researchers began to look for alternatives with similar anticancer properties but fewer side effects. Ruthenium was found to be a promising candidate, considering its significant anticancer properties and low side effects. Several ruthenium complexes, viz. NAMI-A, KP1019, KP1339, and TLD1433, have entered clin. trials. Some other arene ruthenium complexes such as RM175 and RAPTA-C have also entered clin. trials but very few of them have shown anti-metastatic properties. Herein, we provide information and probable mechanistic pathways for ruthenium(II)-arene complexes that have been studied, so far, for their anti-metastatic activities. Also, we discuss the techniques and their significance for determining the anti-metastatic effects of the complexes. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6Related Products of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Related Products of 98-98-6

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Pyridine – Wikipedia,
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Heilman, Patrick’s team published research in Psychoneuroendocrinology in 2019 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Quality Control of Picolinic acid

The author of 《Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits》 were Heilman, Patrick; Hill, Matthew N.; Coussons-Read, Mary; Brundin, Lena; Coccaro, Emil F.. And the article was published in Psychoneuroendocrinology in 2019. Quality Control of Picolinic acid The author mentioned the following in the article:

Kynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these mols. is unknown. The role of these immunobiol. mediators in emotionality and personality traits is not previously characterized. Interleukin-6 (IL-6), 2-arachidonoylglycerol (2-AG) and picolinic acid (PIC) were measured in the plasma of phys. healthy individuals who had history of mood, anxiety, and personality disorders (n = 96) or who had no history of any psychiatric disorder (n = 56) by DSM-5 Criteria. Dimensional assessments of personality were performed using the Eysenck Personality Questionnaire (EPQ) and the Tridimensional Personality Questionnaire (TPQ). Plasma IL-6 levels were significantly associated with plasma 2-AG levels and plasma PIC levels across all subjects. PIC levels were also neg. associated with 2-AG levels across all subjects, independent of IL-6 levels. In our anal. of the biol. determinants of personality factors, we identified significant associations between IL-6 and novelty seeking assessment, and between PIC and neuroticism assessment. These data provide evidence of a biol. link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Quality Control of Picolinic acid

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Yimin’s team published research in Journal of Hazardous Materials in 2021 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Product Details of 98-98-6

Product Details of 98-98-6In 2021 ,《Highly efficient actinide(III)/lanthanide(III) separation by novel pillar[5]arene-based picolinamide ligands: A study on synthesis, solvent extraction and complexation》 appeared in Journal of Hazardous Materials. The author of the article were Cai, Yimin; Ansari, Seraj A.; Fu, Kuirong; Zhu, Beichen; Ma, Haoyang; Chen, Lixi; Conradson, Steven D.; Qin, Song; Fu, Haiying; Mohapatra, Prasanta K.; Yuan, Lihua; Feng, Wen. The article conveys some information:

Selective extraction of highly radiotoxic actinides(III) is an important and challenging task in nuclear wastewater treatment. Many proposed ligands containing S or P atoms have drawbacks including high reagent consumption and possible secondary pollution after incineration. The present work reports five novel pillar[5]arene-based extractants that are anchored with picolinamide substituents of different electronic nature by varying spacer. These ligands reveal highly efficient separation of actinides(III) over lanthanides(III). Specifically, almost all of these ligands could extract Am(III) over Eu(III) selectively at around pH 3.0 (SFAm/Eu > 11) with fast extraction kinetics. Variation of the pyridine nitrogen basicity via changing para-substitution leads to an increase in the distribution ratios by a factor of over 300 times for Am(III) with an electron-withdrawing group compared to those with an electron donating group. Investigation of complexation mechanism by slope anal., NMR, IR, EXAFS, and DFT techniques indicates that each ligand binds two metal ions by pyridine nitrogen and amide oxygen. Finally, these ligands do not show obvious decrease in both extraction and separation ability after being exposed to 250 kGy absorbed gamma radiation. These results demonstrate the potential application of pillar[5]arene-picolinamides for actinide(III) separation In the experiment, the researchers used many compounds, for example, Picolinic acid(cas: 98-98-6Product Details of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Product Details of 98-98-6

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Pyridine – Wikipedia,
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Gehrke, Sarah’s team published research in Journal of Proteome Research in 2019 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Safety of Picolinic acid

Safety of Picolinic acidIn 2019 ,《Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel》 was published in Journal of Proteome Research. The article was written by Gehrke, Sarah; Rice, Sarah; Stefanoni, Davide; Wilkerson, Rebecca B.; Nemkov, Travis; Reisz, Julie A.; Hansen, Kirk C.; Lucas, Alfredo; Cabrales, Pedro; Drew, Kelly; D’Alessandro, Angelo. The article contains the following contents:

Arctic ground squirrels provide a unique model to investigate metabolic responses to hibernation in mammals. During winter months these rodents are exposed to severe hypothermia, prolonged fasting, and hypoxemia. In the light of their role in oxygen transport/off-loading and owing to the absence of nuclei and organelles (and thus de novo protein synthesis capacity), mature red blood cells have evolved metabolic programs to counteract physiol. or pathol. hypoxemia. However, red blood cell metabolism in hibernation has not yet been investigated. Here we employed targeted and untargeted metabolomics approaches to investigate erythrocyte metabolism during entrance to torpor to arousal, with a high resolution of the intermediate time points. We report that torpor and arousal promote metabolism through glycolysis and pentose phosphate pathway, resp., consistent with previous models of oxygen-dependent metabolic modulation in mature erythrocytes. Erythrocytes from hibernating squirrels showed up to 100-fold lower levels of biomarkers of reperfusion injury, such as the pro-inflammatory dicarboxylate succinate. Altered tryptophan metabolism during torpor was here correlated to the accumulation of potentially neurotoxic catabolites kynurenine, quinolinate, and picolinate. Arousal was accompanied by alterations of sulfur metabolism, including sudden spikes in a metabolite putatively identified as thiorphan (level 1 confidence)-a potent inhibitor of several metalloproteases that play a crucial role in nociception and inflammatory complication to reperfusion secondary to ischemia or hemorrhage. Preliminary studies in rats showed that i.v. injection of thiorphan prior to resuscitation mitigates metabolic and cytokine markers of reperfusion injury, etiol. contributors to inflammatory complications after shock. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Safety of Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Safety of Picolinic acid

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kovacs, Alexandra N.’s team published research in Carbohydrate Polymers in 2021 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.HPLC of Formula: 98-98-6

HPLC of Formula: 98-98-6In 2021 ,《Serum protein-hyaluronic acid complex nanocarriers: Structural characterisation and encapsulation possibilities》 appeared in Carbohydrate Polymers. The author of the article were Kovacs, Alexandra N.; Varga, Norbert; Juhasz, Adam; Csapo, Edit. The article conveys some information:

A protein-polysaccharide-based potential nanocarrier system have been developed via a simple, one-step preparation protocol without the use of long-term heating and the utilization of hardly removable crosslinking agents, surfactants, and toxic organic solvents. To the best of our knowledge, this article is the first which summarizes in detail the pH-dependent quant. relationship between the bovine serum albumin (BSA) and hyaluronic acid (HyA) confirmed by several physico-chem. techniques. The formation of colloidal complex nanoconjugates with average diameter of ca. 210-240 nm is strongly depend on the pH and the applied BSA:HyA mass ratio. Particle charge titrations studies strongly support the core-shell type structure, where the BSA core is covered by a thick HyA shell. Besides the optimization of these conditions, the drug encapsulation capacity and the dissolution profiles have been also studied for ibuprofen (IBU) and 2-picolinic acid (2-PA) as model drugs. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6HPLC of Formula: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.HPLC of Formula: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sahoo, Tapan’s team published research in Advanced Synthesis & Catalysis in 2019 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: Picolinic acid

The author of 《Copper-Catalyzed C-4 Carboxylation of 1-Naphthylamide Derivatives with CBr4/MeOH》 were Sahoo, Tapan; Sen, Chiranjit; Singh, Harshvardhan; Suresh, E.; Ghosh, Subhash Chandra. And the article was published in Advanced Synthesis & Catalysis in 2019. Recommanded Product: Picolinic acid The author mentioned the following in the article:

A copper catalyzed C-4 carboxylation reaction of 1-naphthylamide derivatives using carbon tetra bromide and methanol was reported to get corresponding ester derivatives e.g., I. Picolinamide and its derivatives were used as a bidentate directing group for the distal C4-H functionalization. Various substituted naphthylamide derivatives, and anilides were employed for the carboxylation and proceeds in good yields under mild condition. From the outcome of exptl. results, it was proposed that C4-H carboxylation reaction of 1-naphthylamides might proceed through a single electron transfer pathway. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nafrialdi, Nafrialdi’s team published research in Acta medica Indonesiana in 2019 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: Picolinic acid

The author of 《Safety and Efficacy of NC120 for Improving Lipid Profile: A Double Blind Randomized Controlled Trial.》 were Nafrialdi, Nafrialdi; Hudyono, Johannes; Suyatna, Frans D; Setiawati, Arini. And the article was published in Acta medica Indonesiana in 2019. Recommanded Product: Picolinic acid The author mentioned the following in the article:

BACKGROUND: the use of statin to lower blood cholesterol is often associated with bothersome adverse effects such as myopathy and liver dysfunction. NC120 is herbal lipid lowering drug containing red yeast rice (RYR) extract, guggulipid, and chromium picolinate, and expected to have better safety profile. The aim of this study was to evaluate the efficacy and safety profiles of NC120 in lowering blood lipid. METHODS: this was a double blind randomized clinical trial comparing NC120 with placebo in subjects with hypercholesterolemia. Two capsules of NC120 or placebo were administered twice a day for 28 days. Blood total-cholesterol, LDL-cholesterol, and triglyceride were measured on day-0, day-7, and day-28. Unpaired t-test was used to compare study parameter between groups, and one-way ANOVA was used to compare within group. RESULTS: 25 subjects received NC120 and 24 subjects received placebo. Significant decrease of total cholesterol and LDL-cholesterol were observed since day-7 in NC120 group, while the changes in placebo group were not significant at all time of observation. No significant decrease of triglyceride was observed in NC120 group and in placebo group. Side effects were minor and comparable between the two groups. CONCLUSION: NC120 is effective in reducing total cholesterol and LDL-cholesterol, but not triglyceride. This drug shows a good safety profile, and thus can be considered for patients who can not tolerate statin drugs. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Maldonado, S.’s team published research in Journal of Hazardous Materials in 2021 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application of 98-98-6

Maldonado, S.; Lopez-Vizcaino, R.; Rodrigo, M. A.; Canizares, P.; Navarro, V.; Roa, G.; Barrera, C.; Saez, C. published an article in 2021. The article was titled 《Scale-up of electrokinetic permeable reactive barriers for the removal of organochlorine herbicide from spiked soils》, and you may find the article in Journal of Hazardous Materials.Application of 98-98-6 The information in the text is summarized as follows:

This work aims to shed light on the scale-up a combined electrokinetic soil flushing process (EKSF) with permeable reactive barriers (PRB) for the treatment of soil spiked with clopyralid. To do this, remediation tests at lab (3.45 L), bench (175 L) and pilot (1400 L) scales have been carried out. The PRB selected was made of soil merged with particles of zero valent iron (ZVI) and granular activated carbon (GAC). Results show that PRB-EKSF involved electrokinetic transport and dehalogenation as the main mechanisms, while adsorption on GAC was not as relevant as initially expected. Clopyralid was not detected in the electrolyte wells and only in the pilot scale, significant amounts of clopyralid remained in the soil after 600 h of operation. Picolinic acid was the main dehalogenated product detected in the soil after treatment and mobilized by electro-osmosis, mostly to the cathodic well. The transport of volatile compounds into the atm. was promoted at pilot scale because of the larger soil surface exposed to the atm. and the elec. heating caused by ohmic losses and the larger interelectrode gap. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Application of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem