Category: 98027-80-6

Application of 98027-80-6, Adding some certain compound to certain chemical reactions, such as: 98027-80-6, name is 4-Bromo-2,6-dichloropyridine,molecular formula is C5H2BrCl2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98027-80-6.

To a de-gassed mixture of 3-CHLORO-4-FLUOROPHENYLBORONIC acid (77 mg, 0. 44 MMOL)), 4-bromo-2, 6-dichloro-pyridine (Talik and Plazek (1959) ROCZ. CHENT. 33 : 387-92 ; 100 mg, 0. 44 mmol), and 2M Na2CO3 (0. 55 MMOL), in DME (4mL) under nitrogen, add Pd (PPh3) 4 (0. 026 MMOL). Stir the mixture at 80C overnight, concentrate, and extract with EtOAc. Dry over NA2S04, concentrate under vacuum, and purify by preparative TLC (9 : 1 hexanes/EtOAc) to give 2, 3-DICHLORO-4- (3-CHLORO-4-FLUORO-PHENYL)-PYRIDINE.

According to the analysis of related databases, 98027-80-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NEUROGEN CORPORATION; WO2005/7648; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 98027-80-6 , The common heterocyclic compound, 98027-80-6, name is 4-Bromo-2,6-dichloropyridine, molecular formula is C5H2BrCl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(2) In a 250 mL three-neck flask, flush with nitrogen.Added 0.02 mol of raw material 4-bromo-2,6-dichloropyridine,150ml DMF, 0.024mol 4-Biphenylboronic acid pinacol ester,0.0002mol palladium acetate, stirring, then add 0.03mol K3PO4 aqueous solution, heated to 130 C, refluxing reaction for 10 hours, sampling point plate,The reaction is complete. Natural cooling, add water,The mixture was filtered and dried in a vacuum ovenThe resulting residue was purified on a silica gel column to give compound intermediate A1;HPLC purity 99.5%, yield 88.3%.

The synthetic route of 98027-80-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Wang Fang; Zhang Zhaochao; Li Chong; Zhang Xiaoqing; (53 pag.)CN107602538; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem