Category: 98027-84-0

Electric Literature of 98027-84-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 98027-84-0 as follows.

Example A: Synthesis of 5-[3-(2,6-dichloropyridin-4-ylll-3-(trifluoromethyl)-3,4-dihvdro-2H- pyrrol-5-vn-2-(1H-1,2,4-triazoI-1-vnbenzonitrile (No. 1-1)Step 1. Synthesis of ,,6-dichloro-4-(3.3.3-trifluoroprop-1-en-2-yl)pyridine.2,6-dichloro-4-iodopyridine (0.87 g), (3,3,3-trifluoroprop-1-en-2-yl)boronic acid (purity: 65%, 0.75 g) and potassium carbonate (0.96 g) were dissolved in the mixed solvent of THF and water, which was then degassed three times. To the solution was added dichlorobis(triphenylphosphine) palladium (II) (0.04 g), and the mixture was heated to reflux for 3 hours under argon atmosphere. The mixture was cooled to room temperature and then poured into water, which was then extracted twice with hexane. The organic layer was combined, which was then washed with water and dried over anhydrous magnesium sulfate. After the drying agent was filtered off, the solvent was distilled away under reduced pressure, and the residue was then purified by silica gel chromatography to obtain 2,6-dichloro-4-(3,3,3-trifluoroprop-1-en-2-yl)pyridine (0.70 g) at a yield of 82%.1H-NMR(CDC13)delta: 6.03 (1H, s), 6.21 (1H, s), 7.34 (2H, s)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98027-84-0, its application will become more common.

Reference:
Patent; BAYER CROPSCIENCE AG; MURATA, Tetsuya; YONETA, Yasushi; KISHIKAWA, Hidetoshi; MIHARA, Jun; YAMAZAKI, Daiei; HATAZAWA, Mamoru; SASAKI, Norio; DOMON, Kei; SHIMOJO, Eiichi; ICHIHARA, Teruyuki; SHIBUYA, Katsuhiko; ATAKA, Masashi; GOeRGENS, Ulrich; WO2010/133336; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 98027-84-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 98027-84-0 as follows.

Example A: Synthesis of 5-[3-(2,6-dichloropyridin-4-ylll-3-(trifluoromethyl)-3,4-dihvdro-2H- pyrrol-5-vn-2-(1H-1,2,4-triazoI-1-vnbenzonitrile (No. 1-1)Step 1. Synthesis of ,,6-dichloro-4-(3.3.3-trifluoroprop-1-en-2-yl)pyridine.2,6-dichloro-4-iodopyridine (0.87 g), (3,3,3-trifluoroprop-1-en-2-yl)boronic acid (purity: 65%, 0.75 g) and potassium carbonate (0.96 g) were dissolved in the mixed solvent of THF and water, which was then degassed three times. To the solution was added dichlorobis(triphenylphosphine) palladium (II) (0.04 g), and the mixture was heated to reflux for 3 hours under argon atmosphere. The mixture was cooled to room temperature and then poured into water, which was then extracted twice with hexane. The organic layer was combined, which was then washed with water and dried over anhydrous magnesium sulfate. After the drying agent was filtered off, the solvent was distilled away under reduced pressure, and the residue was then purified by silica gel chromatography to obtain 2,6-dichloro-4-(3,3,3-trifluoroprop-1-en-2-yl)pyridine (0.70 g) at a yield of 82%.1H-NMR(CDC13)delta: 6.03 (1H, s), 6.21 (1H, s), 7.34 (2H, s)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98027-84-0, its application will become more common.

Reference:
Patent; BAYER CROPSCIENCE AG; MURATA, Tetsuya; YONETA, Yasushi; KISHIKAWA, Hidetoshi; MIHARA, Jun; YAMAZAKI, Daiei; HATAZAWA, Mamoru; SASAKI, Norio; DOMON, Kei; SHIMOJO, Eiichi; ICHIHARA, Teruyuki; SHIBUYA, Katsuhiko; ATAKA, Masashi; GOeRGENS, Ulrich; WO2010/133336; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98027-84-0, name is 2,6-Dichloro-4-iodopyridine, molecular formula is C5H2Cl2IN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives

Preparative Example 2,6-Dichloro-4-cyclopropylpyridine Cyclopropylzinc bromide (0.5 M in tetrahydrofuran, 15 mL, 7.3 mmol) was added to a mixture of 2,6-dichloro-4-iodopyridine (1.0 g, 3.65 mmol) and tetrakis(triphenylphosphine)palladium(0) (211 mg, 0.182 mmol) in anhydrous tetrahydrofuran (10 mL) at 0 C. After being stirred at room temperature for 4 hours, the reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether: ethyl acetate = 100: 1) to provide 2,6- dichloro-4-cyclopropylpyridine. MS ESI calc’d. for C8H8C12N [M + H]+ 188, found 188. XH NMR: (400 MHz, CDC13) 5 6.89 (s, 2H), 1.87 – 1.80 (m, 1 H), 1.18 – 1.13 (m, 2H), 0.84 – 0.80 (m, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 98027-84-0.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MERCK CANADA INC.; MACHACEK, Michele, R.; ALTMAN, Michael, D.; ROMEO, Eric, T.; VITHARANA, Dilrukshi; CASH, Brandon; SIU, Tony; ZHOU, Hua; CHRISTOPHER, Matthew; KATTAR, Solomon, D.; HAIDLE, Andrew, M.; CHILDERS, Kaleen Konrad; MADDESS, Matthew, L.; REUTERSHAN, Michael, H.; DUCHARME, Yves; GUERIN, David. J.; SPENCER, Kerrie; BEAULIEU, Christian; TRUONG, Vouy Linh; GUAY, Daniel; NORTHRUP, Alan, B.; TAOKA, Brandon, M.; LIM, Jongwon; FISCHER, Christian; BUTCHER, John, W.; OTTE, Ryan, D.; SUN, Binyuan; WO2013/192125; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98027-84-0, name is 2,6-Dichloro-4-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2,6-Dichloro-4-iodopyridine

Example 1A 6-chloro-N-cyclohexyl-4-iodopyridin-2-amine A mixture of 2,6-dichloro-4-iodopyridine (5 g, 18.3 mmol) and cyclohexylamine (18.1 g, 183 mmol) was heated in a Biotage Initiator microwave at 150 C. for 30 min. Ethyl acetate (150 mL) was added and the mixture washed with water (100 mL) and brine (50 mL). The organics were concentrated and the residual oil purified by flash chromatography on silica gel eluding with 10% ethyl acetate in hexanes to provide the title compound. Yield: 4.7 g (76%). MS (DCI/NH3) m/z 337 (M+H)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 98027-84-0, 2,6-Dichloro-4-iodopyridine.

Reference:
Patent; ABBOTT LABORATORIES; US2011/15172; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 98027-84-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.98027-84-0, name is 2,6-Dichloro-4-iodopyridine, molecular formula is C5H2Cl2IN, molecular weight is 273.8866, as common compound, the synthetic route is as follows.

2,6-Dichloro-4-iodo-pyridine (1 g, 3.65 mmol), N-[4-(4,4,5,5-tetramethyl-1 ,3,2- dioxaborolan-2-yl)-2-pyridyl]acetamide (1 .2 g, 4.58 mmol), PdCI2(PPh3)2 (128 mg, 0.18 mmol) and K2CO3 (1 .51 g, 10.95 mmol) were taken up in 1 ,4- dioxane:H2O:EtOH (6:3:1 , 15 ml) and nitrogen was bubbled through the mixture for 5 min before being heated to 80 C for 2 h. When cooled to rt water (10 ml), brine (10 ml) and EtOAc (25 ml) were added, the mixture stirred vigorously for 5 min and the organic layer was separated. The aqueous layer was extracted with EtOAc (3 x 20 ml) and the combined organics were washed with brine, dried over Na2SO4, filtered andconcentrated. Recrystallization from MeCN gave the product as a solid (760 mg, 74%). MS ES+ m/z 282 [M+H]+.

Statistics shows that 98027-84-0 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloro-4-iodopyridine.

Reference:
Patent; SPRINT BIOSCIENCE AB; LINDSTROeM, Johan; FORSBLOM, Rickard; GINMAN, Tobias; RAHM, Fredrik; VIKLUND, Jenny; (89 pag.)WO2019/38387; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 98027-84-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98027-84-0, name is 2,6-Dichloro-4-iodopyridine, molecular formula is C5H2Cl2IN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2,6-dichloro-4-iodopyridine (40 g, 146 mmol), benzenethiol (16.4 mL, 160 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (8.45 g, 14.6 mmol), and diisopropylethylamine (48.3 mL, 292 mmol) in dioxane (600 mL) was flushed with N2 for 5 min before tris(dibenzylideneacetone)dipalladium (0) (6.69 g, 7.30 mmol) was added and the resulting mixture stirred at 110C for 90 min. The resulting suspension was concentrated in vacuo and purified by flash chromatography, eluting with DCM (0 – 40 %) in heptane to yield the title compound as a white solid (28.8 g, 77 ). 1H NMR (500 MHz, DMSO-d6) delta 8.01- 7.39 (m, 5 H), 7.06 (s, 2 H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 98027-84-0, 2,6-Dichloro-4-iodopyridine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BROMIDGE, Steven; BURCH, Jason; HEIFETZ, Alexander; KRULLE, Thomas; MONTALBETTI, Christian A.G.N.; PEI, Zhonghua; PEREZ-FUERTES, Yolanda; TRANI, Giancarlo; (223 pag.)WO2016/1341; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 98027-84-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 98027-84-0, name is 2,6-Dichloro-4-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate Example 5. N-(6-chloro-4-(2,4-difluorophenyl)pyridin-2-yl)cycloprdpanesulfonamidea) 2,6-dichloro-4-(2,4-difluorophenyl)pyridineA solution of 2,6-dichloro-4-iodopyridine (1.5 g, 5.49 mmol) in 1,2-dimethoxy- ethane (15 ml) was degassed by N2 bubbling for 5 mm. 2,4-Difluorophenylboronic acid (0.86 g, 5.49 mmol, 1 eq) was added and the mixture was degassed for another 5 mm. Pd(dppf)C12 (0.358 g, 0.43 mmol, 0.08 eq) and aqueous sodium carbonate (1.45 g, 13.7 mmol, 2.5 eq) were added sequentially using the procedure of Intermediate Example 1 and the mixture was heated at 90 C for 16 h. The reaction mixture was quenched and extracted as in Intermediate Example 1. The solvent was distilled off to afford the cruderesidue which was purified by column chromatography (60-120 silica gel, 3 % ethyl acetate in hexane) to yield the title product in 98.5 % yield (1.4 g).

According to the analysis of related databases, 98027-84-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORION CORPORATION; RAJAGOPALAN, Srinivasan; APPUKUTTAN, Prasad; NARASINGAPURAM ARUMUGAM, Karthikeyan; UJJINAMATADA, Ravi Kotrabasaiah; GEORGE, Shyla; LINNANEN, Tero; WO2014/162039; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem