Category: 98197-88-7

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

To cooled solution of oxalyl chloride (0.533 g, 4.18 mmol) in DCM (2mL) at -78 C. under nitrogen was added dimethyl sulfoxide (0.593 mL, 8.37 mmol) dropwise. After 30 minutes (4-nitro-pyridin-2-yl)-methanol (17)(0.129, 0.837 mmol) in DCM (2 mL) was added dropwise maintaining temperature at -78 C. After 2 hours the mixture was warmed to -55 C. Triethylamine (1.74 mL, 12.55 mmol) was then added and the mixture allowed to warm to room temperature over 2 hours. Brine (10 mL) was then added and the mixture extracted with DCM (4*10 mL). The combined organics were then dried over MgSO4 and concentrated in vacuo to an oil. The material was used directly without need for purification assuming quantitative conversion.

With the rapid development of chemical substances, we look forward to future research findings about 98197-88-7.

Reference:
Patent; KuDOS Pharmaceuticals Limited; US2007/93489; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

To cooled solution of oxalyl chloride (0.533 g, 4.18 mmol) in DCM (2mL) at -78 C. under nitrogen was added dimethyl sulfoxide (0.593 mL, 8.37 mmol) dropwise. After 30 minutes (4-nitro-pyridin-2-yl)-methanol (17)(0.129, 0.837 mmol) in DCM (2 mL) was added dropwise maintaining temperature at -78 C. After 2 hours the mixture was warmed to -55 C. Triethylamine (1.74 mL, 12.55 mmol) was then added and the mixture allowed to warm to room temperature over 2 hours. Brine (10 mL) was then added and the mixture extracted with DCM (4*10 mL). The combined organics were then dried over MgSO4 and concentrated in vacuo to an oil. The material was used directly without need for purification assuming quantitative conversion.

With the rapid development of chemical substances, we look forward to future research findings about 98197-88-7.

Reference:
Patent; KuDOS Pharmaceuticals Limited; US2007/93489; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine, molecular formula is C6H6N2O3, molecular weight is 154.12, as common compound, the synthetic route is as follows.SDS of cas: 98197-88-7

A 200-mL round-bottomed flask was charged with isopropanol (50 mL) and NaH (2.12 g, 53 57 mmol) and stirred at 0 C under inert atmosphere for 1 h. After, (4-nitropyridin-2- yl)methanol (1.0 g, 6.5 mmol) was added to the stirring reaction mixture. The resulting reaction mixture was refluxed for 20 h. After this period, the reaction mixture was cooled with an ice bath, quenched with saturated aqueous NHUCI and concentrated in vacuo. The resulting reside was extracted with EtOAc (3 >< 75 mL). The combined organic layers were dried over anhydrous NaaSC filtered, and concentrated in vacuo. The crude material purified by flash chromatography (60 to 100% EtOAc in hexanes) on silica gel (55 mL) to afford (4~isopropoxypyridin-2-yl)methano (242 mg, 22% yield) as a brown oil. At the same time, in my other blogs, there are other synthetic methods of this type of compound,98197-88-7, 2-(Hydroxymethyl)-4-nitropyridine, and friends who are interested can also refer to it. Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; KOIDE, Kazunori; BEIN, Kiflai; BRESSIN, Robert, Kruger; BURROWS, James, Proviano; GAMBINO, Adriana; LEIKAUF, George, D.; PHAM, Dianne; (80 pag.)WO2020/27905; (2020); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 98197-88-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

2-(methoxymethyl)-4-nitropyridine (i59): To a solution of (4-nitropyridin-2-yl)methanol (i58) (2.3 g, 14.93 mmol) in THF (40 mL), NaH (0.89 g, 22.40 mmol) was added at 0C and stirred for 5 min. Mel (3.18 g, 22.4 mmol) was added and the reaction mixture allowed to warm to room temperature and stirred for 4h. The progress of the reaction was monitored by TLC. After completion, the mixture was quenched with water and extracted with ethyl acetate. The organic layer was separated, dried over sodium sulphate and concentrated under reduced pressure. The crude product was purified by silica gel (60:120 mesh) column chromatography using 10% ethyl acetate in n-hexane as eluent to afford 2-(methoxymethyl)-4-nitropyridine (i59) (0.775 g, Yield 31 %). 1H NMR (400 MHz, DMSO-d6) delta 3.44 (s, 3H), 4.66 (s, 2H), 8.08 – 8.00 (m, 2H), 8.91 (d, J = 5.2 Hz, 1 H). MS (ESI) m/e (M+1 )+: 169.00

According to the analysis of related databases, 98197-88-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UCB BIOPHARMA SPRL; MERCIER, Joel; PROVINS, Laurent; VERMEIREN, Celine; SABNIS, Yogesh Anil; (106 pag.)WO2016/124508; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-(Hydroxymethyl)-4-nitropyridine

To a stirred solution of (4-nitro-2-pyridyl)methanol (3530 mg; 22.3 mmol)[CAS 98197-88-7] in N,N- dimethylformamide (60 mL) were added imidazole (3070 mg; 44.7 mmol) and teri-butyl-chloro- dimethyl-silane (4080 mg; 26.8 mmol) at 0 C. The reaction mixture was allowed to warm up naturally to room temperature and stirred for 18 hours. The reaction mixture was quenched with distilled water (30 mL) and the product was extracted with ethyl acetate (3 x 100 mL). The combined organic layers were washed with brine, dried over anhydrous Na2S04, filtered and concentrated to dryness. The residue was purified by column chromatography (silica gel; petroleum ether: ethyl acetate; 25: 1 ; v/v) to afford tert- butyl-dimethyl-[(4-nitro-2-pyridyl)methoxy]silane (5790 mg) as a light yellow oil. MS m/z (+ESI): 269.0 [M+H]+. ‘H-NMR (400 MHz, DMSO-O delta ppm: 8.89 (d, J= 5.2 Hz, 1H), 8.05 (d, J= 2.4 Hz, 1H), 8.01 (dd, Jl = 5.2 Hz, J2 = 2.4 Hz, 1H), 4.90 (s, 2H), 0.94 (s, 9H), 0.13 (s, 6H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 98197-88-7, 2-(Hydroxymethyl)-4-nitropyridine.

Reference:
Patent; BASILEA PHARMACEUTICA INTERNATIONAL AG; LANE, Heidi; RICHALET, Florian; EL SHEMERLY, Mahmoud; (169 pag.)WO2018/2220; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(Hydroxymethyl)-4-nitropyridine

A 200-mL round-bottomed flask was charged with n-butanol (50 mL) and NaH (2.12 g, 53.57 mmol) and stirred at 0 C under inert atmosphere for 1 h. After, (4~nitropyndin-2~yl)methanol (1.0 g, 6.5 mmol) was added to the stirring reaction mixture. The resulting reaction mixture was refluxed for 20 h. After this period, the reaction mixture was cooled with an ice bath, quenched with saturated aqueous NFUC and concentrated in vacuo. The resulting reside was extracted with EtOAc (3 c 75 mL). The combined organic layers were dried over anhydrous Na2S04, filtered, and concentrated in vacuo. The crude material purified by flash chromatography (80 to 100% EtOAc in hexanes) on silica gel (55 mL) to afford (4- butoxypyridin-2-yl)methanol (599 mg, 51 % yield) as a brown oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 98197-88-7, 2-(Hydroxymethyl)-4-nitropyridine.

Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; KOIDE, Kazunori; BEIN, Kiflai; BRESSIN, Robert, Kruger; BURROWS, James, Proviano; GAMBINO, Adriana; LEIKAUF, George, D.; PHAM, Dianne; (80 pag.)WO2020/27905; (2020); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine. A new synthetic method of this compound is introduced below., Computed Properties of C6H6N2O3

A 100-mL round- bottomed flask open to air was charged with (4-nitropyridin-2-yl)methanol (1.03 g, 6.69 mmol), EtOH (17 mL), and EtONa (1.73 g, 25.4 mmol, 3.8 equiv). The vessel was fitted with a reflux condenser and heated to reflux. After 15 h, more EtONa (2.52 g, 37.0 mmol, 5.5 equiv) was added, and the reaction mixture was let stir at reflux. After 3 h, the reaction mixture was cooled to 23 C and neutralized with aqueous 4.0 M HCI. The mixture was concentrated in vacuo to remove organic solvent and then dissolved in saturated aqueous NaHCOa. The resulting aqueous layer was extracted with CH2CI2 (3 c 30 mL) using a separatory funnel. The combined organic layers were dried over anhydrous Na2S04, filtered, and concentrated in vacuo to afford (4-ethoxypyridin-2~yl)methanol (1.03 g, quantitative yield) as a red solid which was pure by 1H NMR.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 98197-88-7, 2-(Hydroxymethyl)-4-nitropyridine.

Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; KOIDE, Kazunori; BEIN, Kiflai; BRESSIN, Robert, Kruger; BURROWS, James, Proviano; GAMBINO, Adriana; LEIKAUF, George, D.; PHAM, Dianne; (80 pag.)WO2020/27905; (2020); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine. A new synthetic method of this compound is introduced below., Computed Properties of C6H6N2O3

A 100-mL round- bottomed flask open to air was charged with (4-nitropyridin-2-yl)methanol (1.03 g, 6.69 mmol), EtOH (17 mL), and EtONa (1.73 g, 25.4 mmol, 3.8 equiv). The vessel was fitted with a reflux condenser and heated to reflux. After 15 h, more EtONa (2.52 g, 37.0 mmol, 5.5 equiv) was added, and the reaction mixture was let stir at reflux. After 3 h, the reaction mixture was cooled to 23 C and neutralized with aqueous 4.0 M HCI. The mixture was concentrated in vacuo to remove organic solvent and then dissolved in saturated aqueous NaHCOa. The resulting aqueous layer was extracted with CH2CI2 (3 c 30 mL) using a separatory funnel. The combined organic layers were dried over anhydrous Na2S04, filtered, and concentrated in vacuo to afford (4-ethoxypyridin-2~yl)methanol (1.03 g, quantitative yield) as a red solid which was pure by 1H NMR.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 98197-88-7, 2-(Hydroxymethyl)-4-nitropyridine.

Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; KOIDE, Kazunori; BEIN, Kiflai; BRESSIN, Robert, Kruger; BURROWS, James, Proviano; GAMBINO, Adriana; LEIKAUF, George, D.; PHAM, Dianne; (80 pag.)WO2020/27905; (2020); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 98197-88-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine, molecular formula is C6H6N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A (0128) 100-mL round-bottom flask was charged with (4-nitropyridin-2-yl)methanol (1.02 g, 6.63 mmol), CF3CH2OH (17 mL), and CF3CH20Na (3.07 g, 25.2 mmol, 3.8 equiv, prepared from CF3CH2OH and NaH). A reflux condenser was atached, and after the reaction mixture was heated to reflux for 14 h, the reaction mixture was cooled to 23 C, and additional CFsCHteOIMa (2.04 g, 16.7 mmol, 2.5 equiv) was added. The reaction mixture was heated to reflux for 24 h, cooled to 23 C, and neutralized with aqueous 4.0 M HCI. The mixture was concentrated in vacuo. The resulting residue was dissolved in saturated aqueous NaHCOa, and the product was extracted with EtOAc (3 c 30 mL) using a separatory funnel. The combine organic layers were dried over anhydrous NaaSCU, filtered, and concentrated in vacuo to deliver (4-(2,2,2~trifuoroethoxy)pyridin~2- yl)methanol (1.08 g, 79% yield).

According to the analysis of related databases, 98197-88-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; KOIDE, Kazunori; BEIN, Kiflai; BRESSIN, Robert, Kruger; BURROWS, James, Proviano; GAMBINO, Adriana; LEIKAUF, George, D.; PHAM, Dianne; (80 pag.)WO2020/27905; (2020); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 98197-88-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine, molecular formula is C6H6N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of (4-nitropyridin-2-yl)methanol (100 mg, 0.65 mmol) in ethanol (4 mL) was treated with a solution of sodium ethoxide in ethanol (21% by weight, 0.31 mL, 0.83 mmol) and the reaction mixture was heated under reflux for 48 h. Water (10 mL) was added, the mixturewas neutralized with concentrated aq. hydrochloric acid and ethanol was removed by evaporation in vacuo. More water (20 mL) was added and the mixture was extracted with DCM (4 x 30 mL). Extracts were dried (MgSO4) and concentrated to give (4-ethoxypyridin-2- yl)methanol W (73 mg, 73%) as a red oil, used without purification.LCMS (method A): 2.07 (154.1, MH).

According to the analysis of related databases, 98197-88-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; REDAG CROP PROTECTION LTD; URCH, Christopher John; BUTLIN, Roger, John; CHRISTOU, Stephania; BOOTH, Rebecca, Kathryn; (122 pag.)WO2019/77345; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem