Category: 98273-19-9

Reference of 98273-19-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 98273-19-9, name is Methyl 4,6-dichloropicolinate. A new synthetic method of this compound is introduced below.

To a solution of methyl 4,6- dichloropyridine-2-carboxylate (1.0 g, 4.9 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.34 g, 0.29 mmol) in THF (11 mL) was added bromo(cyclopropyl)zinc (11 mL of 0.5 M solution in THF, 5.6 mmol). The solution was heated at 60-65 C for 24 h. The solution was allowed to cool to rt, then poured into saturated aqueous ammonium chloride and extracted with EtOAc. The combined organic phases were dried, filtered and concentrated onto Celite. Purification was by silica gel chromatography using 0-15% EtO Ac/hex to afford the title compound (600 mg) as a colorless solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,98273-19-9, Methyl 4,6-dichloropicolinate, and friends who are interested can also refer to it.

Reference:
Patent; NURIX THERAPEUTICS, INC.; BARSANTI, Paul A.; BENCE, Neil F.; GOSLING, Jennifa; SAHA, Anjanabha; TAHERBHOY, Asad M.; ZAPF, Christoph W.; BOYLE, Kathleen; CARDOZO, Mario; MIHALIC, Jeffrey; LAWRENZ, Morgan; GALLOP, Mark; BRUFFEY, Jilliane; CUMMINS, Thomas; ROBBINS, Daniel; TANAKA, Hiroko; WANG, Chenbo; COHEN, Frederick; PALMER, Wylie; SANDS, Arthur T.; SHUNATONA, Hunter; (968 pag.)WO2019/148005; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 98273-19-9 ,Some common heterocyclic compound, 98273-19-9, molecular formula is C7H5Cl2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A screw-cap vial was charged with methyl 4,6-dichloropicolinate (0.300 g, 1.46 mmol), potassium carbonate (0.302 g, 2.18 mmol), palladium (II) acetate (0.016 g, 0.073 mmol), XPhos (0.104 g, 0.22 mmol), morpholine (0.127 mL, 1.46 mmol), and toluene (5 mL). The yellow solution was stirred at 100 C for 18 h, filtered through Celite and coned. The crude material was purified by columnchromatography (silica, 0-50% EtOAc in hexanes) to afford (in order of elution) methyl 4-chloro-6-morpholinopicolinate and methyl 6-chloro-4-morpholino- picolinate as white amorphous solids. Isomers assigned by NOESY. Mass Spectrum (ESI) m/e = 257.0 (M + 1); 257.0 (M + 1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98273-19-9, its application will become more common.

Reference:
Patent; AMGEN INC.; DRANSFIELD, Paul, John; GONZALEZ LOPEZ DE TURISO, Felix; KOHN, Todd, J.; PATTAROPONG, Vatee; SIMARD, Jillian, L.; WO2012/3283; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 98273-19-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.98273-19-9, name is Methyl 4,6-dichloropicolinate, molecular formula is C7H5Cl2NO2, molecular weight is 206.03, as common compound, the synthetic route is as follows.

Methyl 4-chloro-6- and methyl 6-chloro-4-morpholinopicolinateA screw-cap vial was charged with methyl 4,6-dichloropicolinate (0.300 g, 1.456 mmol), potassium carbonate (0.302 g, 2.184 mmol), palladium (II) acetate (0.016 g, 0.073 mmol), XPhos (0.104 g, 0.22 mmol), morpholine (0.127 mL, 1.46 mmol), and toluene (5 mL). The yellow solution was stirred at 100 C for 18 h, then filtered through Celite and concentrated. The crude material was purified by column chromatography (silica, 0-50% ethyl acetate in hexanes) to afford (in order of elution) methyl 4-chloro-6-morpholinopicolinate and methyl 6-chloro-4- morpholinopicolinate as white amorphous solids. Isomers assigned by NOESY. Mass Spectrum (ESI) m/e = 257.0 (M + 1); 257.0 (M + 1).

Statistics shows that 98273-19-9 is playing an increasingly important role. we look forward to future research findings about Methyl 4,6-dichloropicolinate.

Reference:
Patent; AMGEN INC.; DRANSFIELD, Paul John; GONZALEZ LOPEZ DE TURISO, Felix; PATTAROPONG, Vatee; SIMARD, Jillian L.; WO2012/3264; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem