Category: 99163-12-9

Synthetic Route of 99163-12-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 99163-12-9, name is 4-Pyridin-4-yl-benzaldehyde. A new synthetic method of this compound is introduced below.

Having established an access to both hexT-pyrazolines, and hexT- pyrazoles by selection of reaction conditions, next libraries of both heterocycles from aldehydes, a hydrazide, and hexT-4 were synthesized (Figure 28). While aldehydes are abundantly available to introduce diversity in the heterocycle, the hydrazide had to be synthesized de novo, and therefore lent itself to functionalization with an acylatable primary amine 11 for combinatorial library synthesis. In the course of the library synthesis it was found that aliphatic aldehydes related to isobutyric aldehyde AJ, i.e. branched in a-position, neatly yielded the pyrazoline conjugates hexT-12 in MeCN at 50C (condition A, Table 27) whereas linear aliphatic and benzaldehydes were not reactive (Figure 29). Only a small number of benzaldehydes furnished the pyrazolines hexT- 12 in glacial acetic acid at 50C (Figure 25). However, both branched aliphatic aldehydes, and benzaldehydes yielded pyrazoles hexT-13 (Figure 30) in glacial acetic acid at 60C (condition C, Figure 27). Notably, isatin L gave rise to the spirooxindole hexT-13L under these conditions. Linear aliphatic aldehydes were again not reactive, also pyridine carboxaldehydes and related structures did not yield the corresponding hexT-13 conjugates, likely due to poisoning of the catalyst. In total 23 pyrazolines hexT-12 and 41 pyrazoles hexT-13 were obtained with yields between 0.5 and 3 nmol after purification by HPLC. Usually, branched aliphatic aldehydes gave higher yields than aromatic aldehydes. The pyrazolines hexT-12 and pyrazoles hexT-13 were ligated with each a duplex DNA encoding the heterocycles, and dsDNA sequences encoding the aldehyde building blocks.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,99163-12-9, 4-Pyridin-4-yl-benzaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; TECHNISCHE UNIVERSITAeT DORTMUND; BRUNSCHWEIGER, Andreas; KRAUSE, Norbert; ANTONCHICK, Andrey; KLIKA SKOPIC, Mateja; SALAMON, Hazem; BUGAIN, Olivia; JUNG, Kathrin; WAGNER, Bernd; (72 pag.)WO2017/108741; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 99163-12-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 99163-12-9, name is 4-Pyridin-4-yl-benzaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

25 g (110 mmol) of N-(4-chlorophenyl)-1 ,2-phenylene diamine and 20 g (110 mmol) of biphenyl-4-carboxaldehydewere agitated with 300 mE of 2-methoxy ethanol in a 2000 mE round flask, the temperature of the reaction vessel was increased up to a reflux temperature, and the resultant was agitated for 24 hours. The reaction solution was treated with methylene chloride and water to obtain an organic layer, andanhydrous magnesium sulfate was used to remove moisturefrom the organic layet 12 g of a compound (D) (28% yield)was obtained by colunmizing the resultant after removing asolvent therefrom.Atomic analysis of the compound (D) was performed, andthe results are provided as follows.calcd. C24H16C1N3: C, 75.49; H, 4.22; N, 11. found: C, 75.79; H, 4.11; N, 11.8.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 99163-12-9, 4-Pyridin-4-yl-benzaldehyde.

Reference:
Patent; CHEIL INDUSTRIES, INC.; Park, Moo-Jin; Yu, Eun-Sun; Chae, Mi-Young; (64 pag.)US9444054; (2016); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 99163-12-9 ,Some common heterocyclic compound, 99163-12-9, molecular formula is C12H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Respective aromatic/hetro aromatic aldehydes (6a-r) (0.43 mmol) was added to a pre-mixed solution of compound 5 (0.43 mmol) in ethanol. The reaction content was refluxed for 0.5 h. The solids was filtered and rinsed with ethanol and dried to afford the respective hydrazone derivatives (7a-r) in 82-93 % yield (Scheme-I).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 99163-12-9, 4-Pyridin-4-yl-benzaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sree Lakshmana Rao; Basaveswara Rao, Mandava V.; Prasad; Asian Journal of Chemistry; vol. 31; 3; (2019); p. 627 – 632;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem