Cellier, Marie; Gignoux, Amandine; James, Arthur L.; Orenga, Sylvain; Perry, John D.; Robinson, Shaun N.; Stanforth, Stephen P.; Turnbull, Graeme published their research in Bioorganic & Medicinal Chemistry Letters on December 15 ,2015. The article was titled 《2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms》.Name: N-(2-Chloropyridin-3-yl)-2-nitrobenzamide The article contains the following contents:
A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clin. important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-neg. bacteria and also with two of a panel of 8 Gram-pos. bacteria. In the experimental materials used by the author, we found N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0Name: N-(2-Chloropyridin-3-yl)-2-nitrobenzamide)
N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Name: N-(2-Chloropyridin-3-yl)-2-nitrobenzamide