Chand, Pooran; Kotian, Pravin L.; Morris, Philip E.; Bantia, Shanta; Walsh, David A.; Babu, Yarlagadda S. published the artcile< Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase>, Synthetic Route of 21901-29-1, the main research area is benzoate pyridine derivative preparation influenza neuraminidase inhibitor SAR.
Based upon the activity and X-ray crystallog. studies of tri-substituted benzene derivatives containing carboxylic acid, acetamido and guanidine groups, we investigated the effect of the fourth substituent to fulfill the fourth pocket of neuraminidase enzyme. The groups selected as fourth substituents were hydroxymethyl, hydroxyethyl, oxime and amino. These tetra-substituted benzene derivatives were synthesized and evaluated for neuraminidase inhibitory activity. All these compounds were found to have poorer IC50 values than the tri-substituted compounds Further, benzene ring was replaced by pyridine ring and di, tri and tetra-substituted pyridine derivatives were synthesized. The activity of the pyridine derivatives was comparable to benzene derivatives The fourth substituent seems to disturb the binding of the other three substituents, so the activity is reduced as compared to tri-substituted benzene and pyridine derivatives
Bioorganic & Medicinal Chemistry published new progress about Influenza virus. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Synthetic Route of 21901-29-1.