Parallel synthesis enablement of 2-pyridyl-5-cyano-pyrimidine-6-ones-a novel class of HIF-hydroxylase inhibitors was written by Chang, Shang-Poa;Hungerford, William M.;McDonald, Wayne S.;Maguire, Robert J.;Malony, Kelly Q.;Subramanyam, Chakrapani. And the article was included in Tetrahedron Letters in 2010.Application In Synthesis of 4-Hydroxypicolinonitrile This article mentions the following:
The synthesis of various substituted 2-pyridyl-5-cyanopyrimidin-6-ones was accomplished via a three-step protocol. The key aspects of this parallel protocol were the preparation of amidines from nitriles under mild conditions followed by cyclization with Et (ethoxymethylene)cyanoacetate. In the experiment, the researchers used many compounds, for example, 4-Hydroxypicolinonitrile (cas: 475057-86-4Application In Synthesis of 4-Hydroxypicolinonitrile).
4-Hydroxypicolinonitrile (cas: 475057-86-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 4-Hydroxypicolinonitrile