In 2016,Chapman, Michael R.; Kwan, Maria H. T.; King, Georgina E.; Kyffin, Benjamin A.; Blacker, A. John; Willans, Charlotte E.; Nguyen, Bao N. published 《Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions》.Green Chemistry published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:
A novel, rapid and efficient route to imidazo[1,2-a]pyridines I [R = H, 7-CH3, 6-NO2, etc.] under ambient, aqueous and metal-free conditions was reported. The NaOH-promoted cycloisomerization of N-propargylpyridiniums gave quant. yield in a few minutes (10 g scale). A comparison of common green metrics to current routes showed clear improvements, with at least a one order of magnitude increase in space-time-yield. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Category: pyridine-derivatives)
2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Category: pyridine-derivatives