Recently I am researching about NUCLEAR TRANSLOCATION; DIMERS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473253, 81602956, 81973368]; National Major Program of China during the 13th Five-Year Plan Period [2018ZX09721001-001-001]. Published in SPRINGER in DORDRECHT ,Authors: Yang, Y; Zhou, YZ; Tao, L; Yang, T; Zhao, YL; Luo, YF. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. COA of Formula: C6H5NO
Aberrant activation of ERK signaling pathway usually leads to oncogenesis, and small molecular agents targeting this pathway are impeded by the emergence of drug resistance due to reactivation of ERK signaling. Compound DEL-22379 has been reported to inhibit ERK dimerization which was unaffected by drug-resistant mechanism reactivating the ERK signaling. Here, we discussed a structure-activity relationship study of DEL-22379. Forty-seven analogues were designed and synthesized. Each synthesized compound was biologically evaluated for their inhibitory rates on several tumor cell lines and compounds with high inhibitory rates were further evaluated for IC50 values. The structure-activity relationship of idolin-2-one scaffold and the impact of Z/E configuration on potency were discussed. Potential safety of two synthesized analogues was investigated and in silico docking study of five compounds was performed to understand the structural basis of ERK dimerization inhibition. [GRAPHICS] .
COA of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Yang, Y; Zhou, YZ; Tao, L; Yang, T; Zhao, YL; Luo, YF or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem