Chen, Hongtai; Yang, Yanyan; Wang, Lianxin; Niu, Yuxiang; Guo, Minjie; Ren, Xiangwei; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei published the artcile< Slicing and Splicing of Bromodifluoro-N-arylacetamides: Dearomatization and Difunctionalization of Pyridines>, Computed Properties of 22961-45-1, the main research area is copper catalyzed dearomatization functionalization pyridine bromodifluoroarylacetamide; fluoromethyl iminodihydropyridine synthesis.
Copper-catalyzed dearomatization and difunctionalization of pyridines have been disclosed, in which bromodifluoro-N-arylacetamide was sliced into five fragments and three or four of them were transferred to pyridine partners. Through this reaction, novel N-difluoromethyl-2-imine dihydropyridine derivatives can be conveniently accessed from com. available 4-amino substituted pyridines. This strategy demonstrates a novel fluorination method featuring high atom economy, environmental friendliness, an easily available catalyst, and simple operation.
Organic Letters published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Computed Properties of 22961-45-1.