Chen, Liuxi published the artcileEvaluation of polysaccharide-based chiral stationary phases in modern SFC-MS/MS for enantioselective bioanalysis., Product Details of C18H19Cl2NO4, the main research area is polysaccharide chiral stationary phase supercritical fluid chromatog mass spectrometry; supercritical fluid chromatog tandem mass spectrometry polysaccharide; SFC–MS/MS; chiral bioanalysis; chiral stationary phase; enantiomer; enantioselective bioanalysis; supercritical fluid chromatography.
Aim: The applicability of polysaccharide-based chiral stationary phases in modern supercritical fluid chromatog. (SFC)-MS/MS for chiral bioanal. was evaluated. Materials & methods: Ten popular polysaccharide-based chiral stationary phases (CSPs) were tested using a set of 23 drugs against three cosolvents. The effect of temperature and backpressure on separation was examined Results: The recommended order of CSPs for screening was determined Methanol with 0.1% NH4OH is proven to be the first choice of cosolvent. Temperature of 40°C and backpressure of 10 or 15 MPa are recommended starting conditions. Phospholipid elution profiles on the polysaccharide-based CSPs were reported for the first time under SFC conditions. Conclusion: A simplified screening protocol with straightforward method optimization approaches was generated for SFC chiral assay development in a reasonable time frame with a high success rate.
Bioanalysis published new progress about Blood analysis. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Product Details of C18H19Cl2NO4.