Enantioselective synthesis of trifluoromethyl substituted piperidines with multiple stereogenic centers via hydrogenation of pyridinium hydrochlorides was written by Chen, Mu-Wang;Ye, Zhi-Shi;Chen, Zhang-Pei;Wu, Bo;Zhou, Yong-Gui. And the article was included in Organic Chemistry Frontiers in 2015.Computed Properties of C6H3BrF3N This article mentions the following:
An enantioselective iridium-catalyzed hydrogenation of trifluoromethyl substituted pyridinium hydrochlorides is described. Introduction of a trifluoromethyl group increases the reactivity due to the electron-withdrawing effect. Three stereogenic centers could be generated in one operation. This methodol. provides a convenient route to chiral poly-substituted piperidines I (R = Me, Et; Ar = Ph, 4-MeC6H4, 4-MeOC6H4, 2-naphthyl, etc.) and II (Ar = Ph, 4-CF3C6H4, 3,5-F2C6H3, 1-naphthyl) with up to 90% ee. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Computed Properties of C6H3BrF3N).
2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C6H3BrF3N