Application of 53939-30-3In 2019 ,《Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents》 was published in Angewandte Chemie, International Edition. The article was written by Chen, Tie-Gen; Zhang, Haolin; Mykhailiuk, Pavel K.; Merchant, Rohan R.; Smith, Courtney A.; Qin, Tian; Baran, Phil S.. The article contains the following contents:
This work bridges a gap in the cross-coupling of aliphatic redox-active esters with aryl zinc reagents. Previously limited to primary, secondary, and specialized tertiary centers, a new protocol has been devised to enable the coupling of general tertiary systems using nickel catalysis. The scope of this operationally simple method is broad, and it can be used to simplify the synthesis of medicinally relevant motifs bearing quaternary centers. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Application of 53939-30-3)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application of 53939-30-3