Electric Literature of C6H4N2《Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines》 was published in 2021. The authors were Chen, Yan;Shatskiy, Andrey;Liu, Jian-Quan;Karkas, Markus D.;Wang, Xiang-Shan, and the article was included in《Organic Letters》. The author mentioned the following in the article:
An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates CNCH2C(O)2R (R = Me, Et) with pyridinium salts, e.g., 2-(2-oxo-2-phenylethyl)-isoquinolinium bromide is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds, e.g., I. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .
3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Electric Literature of C6H4N2