A One-Pot Sonogashira Coupling and Annulation Reaction: An Efficient Route toward 4H-Quinolizin-4-ones was written by Chen, Zhengwang;Liu, Tanggao;Ma, Xiaoyue;Liang, Pei;Long, Lipeng;Ye, Min. And the article was included in Synlett in 2019.Recommanded Product: Methyl 2-(5-bromopyridin-2-yl)acetate This article mentions the following:
An efficient one-pot Sonogashira coupling and annulation reaction affording 4H-quinolizin-4-ones I (R1 = Ph, 3-MeC6H4, 2-thienyl, etc.; R2 = MeO2C, EtO2C, CN, etc.; R3 = H, Br, Me) from iodoarenes R1I, 2-R2CH2-5-R3-substituted pyridines and Me propiolate in moderate to excellent yields is described. A variety of substituted iodoarenes and 2-alkylpyridines were well tolerated, and especially the unsaturated double and triple bonds were compatible under the standard conditions. In the experiment, the researchers used many compounds, for example, Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4Recommanded Product: Methyl 2-(5-bromopyridin-2-yl)acetate).
Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: Methyl 2-(5-bromopyridin-2-yl)acetate